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Results: 1 to 20 of 140

1.

Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays.

Kiris E, Nuss JE, Stanford SM, Wanner LM, Cazares L, Maestre MF, Du HT, Gomba GY, Burnett JC, Gussio R, Bottini N, Panchal RG, Kane CD, Tessarollo L, Bavari S.

PLoS One. 2015 Jun 10;10(6):e0129264. doi: 10.1371/journal.pone.0129264. eCollection 2015.

2.

Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy.

Doody KM, Stanford SM, Sacchetti C, D Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, Corr M, Esko JD, Tremblay ML, Firestein GS, Aricescu AR, Bottini N.

Sci Transl Med. 2015 May 20;7(288):288ra76. doi: 10.1126/scitranslmed.aaa4616.

PMID:
25995222
3.

Allosteric Small Molecule Inhibitors of LMPTP.

Ardecky RJ, Hedrick MP, Stanford SM, Bliss MR, Zou J, Gosalia P, Yamamoto F, Milewski M, Barron N, Sun Q, Ganji S, Mehta A, Sugarman E, Nguyen K, Vasile S, Suyama E, Mangravita-Novo A, Salaniwal S, Kung P, Smith LH, Sergienko E, Chung TDY, Pinkerton AB, Bottini N.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2014 Apr 15 [updated 2015 Jan 16].

4.

Polyethylene-glycol-modified single-walled carbon nanotubes for intra-articular delivery to chondrocytes.

Sacchetti C, Liu-Bryan R, Magrini A, Rosato N, Bottini N, Bottini M.

ACS Nano. 2014 Dec 23;8(12):12280-91. doi: 10.1021/nn504537b. Epub 2014 Nov 26.

5.

TGFβ responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness.

Stanford SM, Aleman Muench GR, Bartok B, Sacchetti C, Kiosses WB, Sharma J, Maestre MF, Bottini M, Mustelin T, Boyle DL, Firestein GS, Bottini N.

Ann Rheum Dis. 2014 Nov 6. pii: annrheumdis-2014-205790. doi: 10.1136/annrheumdis-2014-205790. [Epub ahead of print]

PMID:
25378349
6.

Ion channel TRPV1-dependent activation of PTP1B suppresses EGFR-associated intestinal tumorigenesis.

de Jong PR, Takahashi N, Harris AR, Lee J, Bertin S, Jeffries J, Jung M, Duong J, Triano AI, Lee J, Niv Y, Herdman DS, Taniguchi K, Kim CW, Dong H, Eckmann L, Stanford SM, Bottini N, Corr M, Raz E.

J Clin Invest. 2014 Sep;124(9):3793-806. doi: 10.1172/JCI72340. Epub 2014 Aug 1.

7.

"PEST control": regulation of molecular barcodes by tyrosine phosphatases.

Doody KM, Bottini N.

Cell Res. 2014 Sep;24(9):1027-8. doi: 10.1038/cr.2014.100. Epub 2014 Aug 1.

PMID:
25081059
8.

PTPN22: the archetypal non-HLA autoimmunity gene.

Stanford SM, Bottini N.

Nat Rev Rheumatol. 2014 Oct;10(10):602-11. doi: 10.1038/nrrheum.2014.109. Epub 2014 Jul 8. Review.

PMID:
25003765
9.

The protein tyrosine phosphatase PTPN22 controls forkhead box protein 3 T regulatory cell induction but is dispensable for T helper type 1 cell polarization.

Fousteri G, Jofra T, Debernardis I, Stanford SM, Laurenzi A, Bottini N, Battaglia M.

Clin Exp Immunol. 2014 Oct;178(1):178-89. doi: 10.1111/cei.12393.

PMID:
24905474
10.

Targeted nanodrugs for cancer therapy: prospects and challenges.

Bottini M, Sacchetti C, Pietroiusti A, Bellucci S, Magrini A, Rosato N, Bottini N.

J Nanosci Nanotechnol. 2014 Jan;14(1):98-114. Review.

PMID:
24730253
11.

Autoimmunity-associated LYP-W620 does not impair thymic negative selection of autoreactive T cells.

Wu DJ, Zhou W, Enouz S, Orrú V, Stanford SM, Maine CJ, Rapini N, Sawatzke K, Engel I, Fiorillo E, Sherman LA, Kronenberg M, Zehn D, Peterson E, Bottini N.

PLoS One. 2014 Feb 3;9(2):e86677. doi: 10.1371/journal.pone.0086677. eCollection 2014.

12.

Covalent inhibition of the lymphoid tyrosine phosphatase.

Ahmed VF, Bottini N, Barrios AM.

ChemMedChem. 2014 Feb;9(2):296-9. doi: 10.1002/cmdc.201300404. Epub 2014 Jan 8.

13.

Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease.

Bottini N, Peterson EJ.

Annu Rev Immunol. 2014;32:83-119. doi: 10.1146/annurev-immunol-032713-120249. Epub 2013 Dec 18. Review.

PMID:
24364806
14.

Cellular biochemistry methods for investigating protein tyrosine phosphatases.

Stanford SM, Ahmed V, Barrios AM, Bottini N.

Antioxid Redox Signal. 2014 May 10;20(14):2160-78. doi: 10.1089/ars.2013.5731. Epub 2014 Feb 25. Review.

15.

Epigenetics in rheumatoid arthritis: a primer for rheumatologists.

Bottini N, Firestein GS.

Curr Rheumatol Rep. 2013 Nov;15(11):372. doi: 10.1007/s11926-013-0372-9. Review.

PMID:
24072602
16.

Substrate selection influences molecular recognition in a screen for lymphoid tyrosine phosphatase inhibitors.

Kulkarni RA, Vellore NA, Bliss MR, Stanford SM, Falk MD, Bottini N, Baron R, Barrios AM.

Chembiochem. 2013 Sep 2;14(13):1640-7. doi: 10.1002/cbic.201300273. Epub 2013 Aug 16.

17.

pCAP-based peptide substrates: the new tool in the box of tyrosine phosphatase assays.

Stanford SM, Krishnamurthy D, Kulkarni RA, Karver CE, Bruenger E, Walker LM, Ma CT, Chung TD, Sergienko E, Bottini N, Barrios AM.

Methods. 2014 Jan 15;65(2):165-74. doi: 10.1016/j.ymeth.2013.07.022. Epub 2013 Jul 22. Review.

18.

Thiuram disulfides as pseudo-irreversible inhibitors of lymphoid tyrosine phosphatase.

Kulkarni RA, Stanford SM, Vellore NA, Krishnamurthy D, Bliss MR, Baron R, Bottini N, Barrios AM.

ChemMedChem. 2013 Sep;8(9):1561-8. doi: 10.1002/cmdc.201300215. Epub 2013 Jul 19.

19.

The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity.

Wang Y, Shaked I, Stanford SM, Zhou W, Curtsinger JM, Mikulski Z, Shaheen ZR, Cheng G, Sawatzke K, Campbell AM, Auger JL, Bilgic H, Shoyama FM, Schmeling DO, Balfour HH Jr, Hasegawa K, Chan AC, Corbett JA, Binstadt BA, Mescher MF, Ley K, Bottini N, Peterson EJ.

Immunity. 2013 Jul 25;39(1):111-22. doi: 10.1016/j.immuni.2013.06.013. Epub 2013 Jul 18.

20.

A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases.

He Y, Liu S, Menon A, Stanford S, Oppong E, Gunawan AM, Wu L, Wu DJ, Barrios AM, Bottini N, Cato AC, Zhang ZY.

J Med Chem. 2013 Jun 27;56(12):4990-5008. doi: 10.1021/jm400248c. Epub 2013 Jun 6.

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