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Chronic Co-Administration of Sepiapterin and l-Citrulline Ameliorates Diabetic Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury in Obese Type 2 Diabetic Mice.

Baumgardt SL, Paterson M, Leucker TM, Fang J, Zhang DX, Bosnjak ZJ, Warltier DC, Kersten JR, Ge ZD.

Circ Heart Fail. 2016 Jan;9(1):e002424. doi: 10.1161/CIRCHEARTFAILURE.115.002424.


Altered Mitochondrial Dynamics Contributes to Propofol-induced Cell Death in Human Stem Cell-derived Neurons.

Twaroski DM, Yan Y, Zaja I, Clark E, Bosnjak ZJ, Bai X.

Anesthesiology. 2015 Nov;123(5):1067-83. doi: 10.1097/ALN.0000000000000857.


MicroRNA-21 Mediates Isoflurane-induced Cardioprotection against Ischemia-Reperfusion Injury via Akt/Nitric Oxide Synthase/Mitochondrial Permeability Transition Pore Pathway.

Qiao S, Olson JM, Paterson M, Yan Y, Zaja I, Liu Y, Riess ML, Kersten JR, Liang M, Warltier DC, Bosnjak ZJ, Ge ZD.

Anesthesiology. 2015 Oct;123(4):786-98. doi: 10.1097/ALN.0000000000000807.


MicroRNAs: New Players in Anesthetic-Induced Developmental Neurotoxicity.

Twaroski D, Bosnjak ZJ, Bai X.

Pharm Anal Acta. 2015;6:357.


Comparison of Cardiomyocyte Differentiation Potential Between Type 1 Diabetic Donor- and Nondiabetic Donor-Derived Induced Pluripotent Stem Cells.

Kikuchi C, Bienengraeber M, Canfield S, Koopmeiner A, Schäfer R, Bosnjak ZJ, Bai X.

Cell Transplant. 2015;24(12):2491-504. doi: 10.3727/096368914X685762. Epub 2015 Jan 5.


Up-regulation of microRNA-21 mediates isoflurane-induced protection of cardiomyocytes.

Olson JM, Yan Y, Bai X, Ge ZD, Liang M, Kriegel AJ, Twaroski DM, Bosnjak ZJ.

Anesthesiology. 2015 Apr;122(4):795-805. doi: 10.1097/ALN.0000000000000567.


Cdk1, PKCδ and calcineurin-mediated Drp1 pathway contributes to mitochondrial fission-induced cardiomyocyte death.

Zaja I, Bai X, Liu Y, Kikuchi C, Dosenovic S, Yan Y, Canfield SG, Bosnjak ZJ.

Biochem Biophys Res Commun. 2014 Oct 31;453(4):710-21. doi: 10.1016/j.bbrc.2014.09.144. Epub 2014 Oct 14.


Mitochondrial targets for volatile anesthetics against cardiac ischemia-reperfusion injury.

Agarwal B, Stowe DF, Dash RK, Bosnjak ZJ, Camara AK.

Front Physiol. 2014 Sep 16;5:341. doi: 10.3389/fphys.2014.00341. eCollection 2014. Review.


Emerging model in anesthetic developmental neurotoxicity: human stem cells.

Bai X, Bosnjak ZJ.

Int J Clin Anesthesiol. 2013 Jul;1:1002. No abstract available.


Down-regulation of microRNA-21 is involved in the propofol-induced neurotoxicity observed in human stem cell-derived neurons.

Twaroski DM, Yan Y, Olson JM, Bosnjak ZJ, Bai X.

Anesthesiology. 2014 Oct;121(4):786-800. doi: 10.1097/ALN.0000000000000345.


Isoflurane modulates cardiac mitochondrial bioenergetics by selectively attenuating respiratory complexes.

Agarwal B, Dash RK, Stowe DF, Bosnjak ZJ, Camara AK.

Biochim Biophys Acta. 2014 Mar;1837(3):354-65. doi: 10.1016/j.bbabio.2013.11.006. Epub 2013 Dec 17.


Cardioprotection during diabetes: the role of mitochondrial DNA.

Muravyeva M, Baotic I, Bienengraeber M, Lazar J, Bosnjak ZJ, Sedlic F, Warltier DC, Kersten JR.

Anesthesiology. 2014 Apr;120(4):870-9. doi: 10.1097/ALN.0000000000000107.


Modeling anesthetic developmental neurotoxicity using human stem cells.

Bai X, Twaroski D, Bosnjak ZJ.

Semin Cardiothorac Vasc Anesth. 2013 Dec;17(4):276-87. doi: 10.1177/1089253213495923. Epub 2013 Jul 16. Review.


miR-21 contributes to xenon-conferred amelioration of renal ischemia-reperfusion injury in mice.

Jia P, Teng J, Zou J, Fang Y, Zhang X, Bosnjak ZJ, Liang M, Ding X.

Anesthesiology. 2013 Sep;119(3):621-30. doi: 10.1097/ALN.0b013e318298e5f1.


Ketamine enhances human neural stem cell proliferation and induces neuronal apoptosis via reactive oxygen species-mediated mitochondrial pathway.

Bai X, Yan Y, Canfield S, Muravyeva MY, Kikuchi C, Zaja I, Corbett JA, Bosnjak ZJ.

Anesth Analg. 2013 Apr;116(4):869-80. doi: 10.1213/ANE.0b013e3182860fc9. Epub 2013 Mar 4.


Preconditioning by isoflurane elicits mitochondrial protective mechanisms independent of sarcolemmal KATP channel in mouse cardiomyocytes.

Muravyeva M, Sedlic F, Dolan N, Bosnjak ZJ, Stadnicka A.

J Cardiovasc Pharmacol. 2013 May;61(5):369-77. doi: 10.1097/FJC.0b013e318285f55b.


Quantitative characterization of changes in the cardiac mitochondrial proteome during anesthetic preconditioning and ischemia.

Bienengraeber M, Pellitteri-Hahn M, Hirata N, Baye TM, Bosnjak ZJ, Olivier M.

Physiol Genomics. 2013 Mar 1;45(5):163-70. doi: 10.1152/physiolgenomics.00117.2012. Epub 2013 Jan 8.


Ketamine induces toxicity in human neurons differentiated from embryonic stem cells via mitochondrial apoptosis pathway.

Bosnjak ZJ, Yan Y, Canfield S, Muravyeva MY, Kikuchi C, Wells CW, Corbett JA, Bai X.

Curr Drug Saf. 2012 Apr;7(2):106-19.


Comparison of cardiomyogenic potential among human ESC and iPSC lines.

Sepac A, Si-Tayeb K, Sedlic F, Barrett S, Canfield S, Duncan SA, Bosnjak ZJ, Lough JW.

Cell Transplant. 2012;21(11):2523-30. doi: 10.3727/096368912X653165. Epub 2012 Aug 2.


Marked hyperglycemia attenuates anesthetic preconditioning in human-induced pluripotent stem cell-derived cardiomyocytes.

Canfield SG, Sepac A, Sedlic F, Muravyeva MY, Bai X, Bosnjak ZJ.

Anesthesiology. 2012 Oct;117(4):735-44.

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