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Results: 1 to 20 of 29


Monoterpene indole alkaloid hydrazone derivatives with apoptosis inducing activity in human HCT116 colon and HepG2 liver carcinoma cells.

Paterna A, Borralho PM, Gomes SE, Mulhovo S, Rodrigues CM, Ferreira MJ.

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3556-9. doi: 10.1016/j.bmcl.2015.06.084. Epub 2015 Jun 30.


Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives.

Brito H, Martins AC, Lavrado J, Mendes E, Francisco AP, Santos SA, Ohnmacht SA, Kim NS, Rodrigues CM, Moreira R, Neidle S, Borralho PM, Paulo A.

PLoS One. 2015 May 29;10(5):e0126891. doi: 10.1371/journal.pone.0126891. eCollection 2015.


Cyclopentadienyl-ruthenium(II) and iron(II) organometallic compounds with carbohydrate derivative ligands as good colorectal anticancer agents.

Florindo PR, Pereira DM, Borralho PM, Rodrigues CM, Piedade MF, Fernandes AC.

J Med Chem. 2015 May 28;58(10):4339-47. doi: 10.1021/acs.jmedchem.5b00403. Epub 2015 May 15.


Aberrant MEK5/ERK5 signalling contributes to human colon cancer progression via NF-κB activation.

Simões AE, Pereira DM, Gomes SE, Brito H, Carvalho T, French A, Castro RE, Steer CJ, Thibodeau SN, Rodrigues CM, Borralho PM.

Cell Death Dis. 2015 Apr 9;6:e1718. doi: 10.1038/cddis.2015.83.


KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines.

Lavrado J, Brito H, Borralho PM, Ohnmacht SA, Kim NS, Leitão C, Pisco S, Gunaratnam M, Rodrigues CM, Moreira R, Neidle S, Paulo A.

Sci Rep. 2015 Apr 8;5:9696. doi: 10.1038/srep09696.


Isolation of mitochondria from liver and extraction of total RNA and protein: analyses of microRNA and protein expressions.

Borralho PM, Steer CJ, Rodrigues CM.

Methods Mol Biol. 2015;1241:9-22. doi: 10.1007/978-1-4939-1875-1_2.


6-Acetonyldihydrochelerythrine Is a Potent Inducer of Apoptosis in HCT116 and SW620 Colon Cancer Cells.

Mansoor TA, Borralho PM, Luo X, Mulhovo S, Rodrigues CM, Ferreira MJ.

J Nat Prod. 2014 Jul 28. [Epub ahead of print]


Insights into the mechanisms underlying the antiproliferative potential of a Co(II) coordination compound bearing 1,10-phenanthroline-5,6-dione: DNA and protein interaction studies.

Luís DV, Silva J, Tomaz AI, de Almeida RF, Larguinho M, Baptista PV, Martins LM, Silva TF, Borralho PM, Rodrigues CM, Rodrigues AS, Pombeiro AJ, Fernandes AR.

J Biol Inorg Chem. 2014 Aug;19(6):787-803. doi: 10.1007/s00775-014-1110-0. Epub 2014 Jan 31.


c-Jun N-terminal kinase 1/c-Jun activation of the p53/microRNA 34a/sirtuin 1 pathway contributes to apoptosis induced by deoxycholic acid in rat liver.

Ferreira DM, Afonso MB, Rodrigues PM, Simão AL, Pereira DM, Borralho PM, Rodrigues CM, Castro RE.

Mol Cell Biol. 2014 Mar;34(6):1100-20. doi: 10.1128/MCB.00420-13. Epub 2014 Jan 13.


Synthesis, G-quadruplex stabilisation, docking studies, and effect on cancer cells of indolo[3,2-b]quinolines with one, two, or three basic side chains.

Lavrado J, Borralho PM, Ohnmacht SA, Castro RE, Rodrigues CM, Moreira R, dos Santos DJ, Neidle S, Paulo A.

ChemMedChem. 2013 Oct;8(10):1648-61. doi: 10.1002/cmdc.201300288. Epub 2013 Aug 19.


Monoterpene bisindole alkaloids, from the African medicinal plant Tabernaemontana elegans, induce apoptosis in HCT116 human colon carcinoma cells.

Mansoor TA, Borralho PM, Dewanjee S, Mulhovo S, Rodrigues CM, Ferreira MJ.

J Ethnopharmacol. 2013 Sep 16;149(2):463-70. doi: 10.1016/j.jep.2013.06.051. Epub 2013 Jul 17.


Biological characterization of the antiproliferative potential of Co(II) and Sn(IV) coordination compounds in human cancer cell lines: a comparative proteomic approach.

Silva A, Luís D, Santos S, Silva J, Mendo AS, Coito L, Silva TF, da Silva MF, Martins LM, Pombeiro AJ, Borralho PM, Rodrigues CM, Cabral MG, Videira PA, Monteiro C, Fernandes AR.

Drug Metabol Drug Interact. 2013;28(3):167-76. doi: 10.1515/dmdi-2013-0015.


Apoptosis inducing activity of benzophenanthridine-type alkaloids and 2-arylbenzofuran neolignans in HCT116 colon carcinoma cells.

Mansoor TA, Borralho PM, Luo X, Mulhovo S, Rodrigues CM, Ferreira MJ.

Phytomedicine. 2013 Jul 15;20(10):923-9. doi: 10.1016/j.phymed.2013.03.026. Epub 2013 Apr 30.


Efficient recovery of proteins from multiple source samples after TRIzol(®) or TRIzol(®)LS RNA extraction and long-term storage.

Simões AE, Pereira DM, Amaral JD, Nunes AF, Gomes SE, Rodrigues PM, Lo AC, D'Hooge R, Steer CJ, Thibodeau SN, Borralho PM, Rodrigues CM.

BMC Genomics. 2013 Mar 15;14:181. doi: 10.1186/1471-2164-14-181.


Delivering the promise of miRNA cancer therapeutics.

Pereira DM, Rodrigues PM, Borralho PM, Rodrigues CM.

Drug Discov Today. 2013 Mar;18(5-6):282-9. doi: 10.1016/j.drudis.2012.10.002. Epub 2012 Oct 11. Review.


Cobalt complexes bearing scorpionate ligands: synthesis, characterization, cytotoxicity and DNA cleavage.

Silva TF, Martins LM, Guedes da Silva MF, Fernandes AR, Silva A, Borralho PM, Santos S, Rodrigues CM, Pombeiro AJ.

Dalton Trans. 2012 Nov 7;41(41):12888-97. doi: 10.1039/c2dt11577h.


miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease.

Castro RE, Ferreira DM, Afonso MB, Borralho PM, Machado MV, Cortez-Pinto H, Rodrigues CM.

J Hepatol. 2013 Jan;58(1):119-25. doi: 10.1016/j.jhep.2012.08.008. Epub 2012 Aug 15.


miR-143 overexpression impairs growth of human colon carcinoma xenografts in mice with induction of apoptosis and inhibition of proliferation.

Borralho PM, Simões AE, Gomes SE, Lima RT, Carvalho T, Ferreira DM, Vasconcelos MH, Castro RE, Rodrigues CM.

PLoS One. 2011;6(8):e23787. doi: 10.1371/journal.pone.0023787. Epub 2011 Aug 25.


miRNA expression in colon polyps provides evidence for a multihit model of colon cancer.

Oberg AL, French AJ, Sarver AL, Subramanian S, Morlan BW, Riska SM, Borralho PM, Cunningham JM, Boardman LA, Wang L, Smyrk TC, Asmann Y, Steer CJ, Thibodeau SN.

PLoS One. 2011;6(6):e20465. doi: 10.1371/journal.pone.0020465. Epub 2011 Jun 9.


Identification of microRNAs during rat liver regeneration after partial hepatectomy and modulation by ursodeoxycholic acid.

Castro RE, Ferreira DM, Zhang X, Borralho PM, Sarver AL, Zeng Y, Steer CJ, Kren BT, Rodrigues CM.

Am J Physiol Gastrointest Liver Physiol. 2010 Oct;299(4):G887-97. doi: 10.1152/ajpgi.00216.2010. Epub 2010 Aug 5.

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