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Items: 20


DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination.

Qin W, Wolf P, Liu N, Link S, Smets M, La Mastra F, Forné I, Pichler G, Hörl D, Fellinger K, Spada F, Bonapace IM, Imhof A, Harz H, Leonhardt H.

Cell Res. 2015 Aug;25(8):911-29. doi: 10.1038/cr.2015.72. Epub 2015 Jun 12.


Inflammatory cues acting on the adult intestinal stem cells and the early onset of cancer (review).

De Lerma Barbaro A, Perletti G, Bonapace IM, Monti E.

Int J Oncol. 2014 Sep;45(3):959-68. doi: 10.3892/ijo.2014.2490. Epub 2014 Jun 10. Review.


Poly(ADP-ribose) polymerase 1 (PARP1) associates with E3 ubiquitin-protein ligase UHRF1 and modulates UHRF1 biological functions.

De Vos M, El Ramy R, Quénet D, Wolf P, Spada F, Magroun N, Babbio F, Schreiber V, Leonhardt H, Bonapace IM, Dantzer F.

J Biol Chem. 2014 Jun 6;289(23):16223-38. doi: 10.1074/jbc.M113.527424. Epub 2014 Apr 29.


Targeted DNA methylation by homology-directed repair in mammalian cells. Transcription reshapes methylation on the repaired gene.

Morano A, Angrisano T, Russo G, Landi R, Pezone A, Bartollino S, Zuchegna C, Babbio F, Bonapace IM, Allen B, Muller MT, Chiariotti L, Gottesman ME, Porcellini A, Avvedimento EV.

Nucleic Acids Res. 2014 Jan;42(2):804-21. doi: 10.1093/nar/gkt920. Epub 2013 Oct 16.


Knock-down of methyl CpG-binding protein 2 (MeCP2) causes alterations in cell proliferation and nuclear lamins expression in mammalian cells.

Babbio F, Castiglioni I, Cassina C, Gariboldi MB, Pistore C, Magnani E, Badaracco G, Monti E, Bonapace IM.

BMC Cell Biol. 2012 Jul 11;13:19. doi: 10.1186/1471-2121-13-19.


The SRA protein UHRF1 promotes epigenetic crosstalks and is involved in prostate cancer progression.

Babbio F, Pistore C, Curti L, Castiglioni I, Kunderfranco P, Brino L, Oudet P, Seiler R, Thalman GN, Roggero E, Sarti M, Pinton S, Mello-Grand M, Chiorino G, Catapano CV, Carbone GM, Bonapace IM.

Oncogene. 2012 Nov 15;31(46):4878-87. doi: 10.1038/onc.2011.641. Epub 2012 Feb 13.


UHRF1 coordinates peroxisome proliferator activated receptor gamma (PPARG) epigenetic silencing and mediates colorectal cancer progression.

Sabatino L, Fucci A, Pancione M, Carafa V, Nebbioso A, Pistore C, Babbio F, Votino C, Laudanna C, Ceccarelli M, Altucci L, Bonapace IM, Colantuoni V.

Oncogene. 2012 Dec 6;31(49):5061-72. doi: 10.1038/onc.2012.3. Epub 2012 Jan 30.


The multi-domain protein Np95 connects DNA methylation and histone modification.

Rottach A, Frauer C, Pichler G, Bonapace IM, Spada F, Leonhardt H.

Nucleic Acids Res. 2010 Apr;38(6):1796-804. doi: 10.1093/nar/gkp1152. Epub 2009 Dec 21.


Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells.

Meilinger D, Fellinger K, Bultmann S, Rothbauer U, Bonapace IM, Klinkert WE, Spada F, Leonhardt H.

EMBO Rep. 2009 Nov;10(11):1259-64. doi: 10.1038/embor.2009.201. Epub 2009 Oct 2.


Novel approaches on epigenetics.

Papait R, Monti E, Bonapace IM.

Curr Opin Drug Discov Devel. 2009 Mar;12(2):264-75. Review.


Interaction between the inner nuclear membrane lamin B receptor and the heterochromatic methyl binding protein, MeCP2.

Guarda A, Bolognese F, Bonapace IM, Badaracco G.

Exp Cell Res. 2009 Jul 1;315(11):1895-903. doi: 10.1016/j.yexcr.2009.01.019. Epub 2009 Feb 2.


The PHD domain of Np95 (mUHRF1) is involved in large-scale reorganization of pericentromeric heterochromatin.

Papait R, Pistore C, Grazini U, Babbio F, Cogliati S, Pecoraro D, Brino L, Morand AL, Dechampesme AM, Spada F, Leonhardt H, McBlane F, Oudet P, Bonapace IM.

Mol Biol Cell. 2008 Aug;19(8):3554-63. doi: 10.1091/mbc.E07-10-1059. Epub 2008 May 28.


Np95 is implicated in pericentromeric heterochromatin replication and in major satellite silencing.

Papait R, Pistore C, Negri D, Pecoraro D, Cantarini L, Bonapace IM.

Mol Biol Cell. 2007 Mar;18(3):1098-106. Epub 2006 Dec 20.


A cancer-specific transcriptional signature in human neoplasia.

Nicassio F, Bianchi F, Capra M, Vecchi M, Confalonieri S, Bianchi M, Pajalunga D, Crescenzi M, Bonapace IM, Di Fiore PP.

J Clin Invest. 2005 Nov;115(11):3015-25. Epub 2005 Oct 13.


Np95 is a histone-binding protein endowed with ubiquitin ligase activity.

Citterio E, Papait R, Nicassio F, Vecchi M, Gomiero P, Mantovani R, Di Fiore PP, Bonapace IM.

Mol Cell Biol. 2004 Mar;24(6):2526-35.


Np95 is regulated by E1A during mitotic reactivation of terminally differentiated cells and is essential for S phase entry.

Bonapace IM, Latella L, Papait R, Nicassio F, Sacco A, Muto M, Crescenzi M, Di Fiore PP.

J Cell Biol. 2002 Jun 10;157(6):909-14. Epub 2002 Jun 10.


Stimulation of human breast cancer MCF-7 cells with estrogen prevents cell cycle arrest by HMG-CoA reductase inhibitors.

Addeo R, Altucci L, Battista T, Bonapace IM, Cancemi M, Cicatiello L, Germano D, Pacilio C, Salzano S, Bresciani F, Weisz A.

Biochem Biophys Res Commun. 1996 Mar 27;220(3):864-70.


17 beta-Estradiol overcomes a G1 block induced by HMG-CoA reductase inhibitors and fosters cell cycle progression without inducing ERK-1 and -2 MAP kinases activation.

Bonapace IM, Addeo R, Altucci L, Cicatiello L, Bifulco M, Laezza C, Salzano S, Sica V, Bresciani F, Weisz A.

Oncogene. 1996 Feb 15;12(4):753-63.


v-ras and protein kinase C dedifferentiate thyroid cells by down-regulating nuclear cAMP-dependent protein kinase A.

Gallo A, Benusiglio E, Bonapace IM, Feliciello A, Cassano S, Garbi C, Musti AM, Gottesman ME, Avvedimento EV.

Genes Dev. 1992 Sep;6(9):1621-30.


Extinction and activation of the thyroglobulin promoter in hybrids of differentiated and transformed thyroid cells.

Bonapace IM, Sanchez M, Obici S, Gallo A, Garofalo S, Gentile R, Cocozza S, Avvedimento EV.

Mol Cell Biol. 1990 Mar;10(3):1033-40.

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