Synthesis, biological properties, and acid dissociation constant of novel naphthoquinone-triazole hybrids.
Nural Y, Ozdemir S, Doluca O, Demir B, Yalcin MS, Atabey H, Kanat B, Erat S, Sari H, Seferoglu Z.
Nural Y, et al.
Bioorg Chem. 2020 Dec;105:104441. doi: 10.1016/j.bioorg.2020.104441. Epub 2020 Oct 29.
Bioorg Chem. 2020.
PMID: 33181409
A series of novel 1,4-naphthoquinone-triazole hybrids, N-(3-amino-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-2-(4-R-1H-1,2,3-triazol-1-yl)acetamide, was synthesized by click chemistry in the presence of sodium ascorbate and copper(II) sulfate pentahydrate in 81-94% yield …
A series of novel 1,4-naphthoquinone-triazole hybrids, N-(3-amino-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-2-(4-R-1H-1,2,3-triazol-1-yl)acetami …