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Synthesis and evaluation of a (3R,6S,9S)-2-oxo-1-azabicyclo[4.3.0]nonane scaffold as a mimic of Xaa-trans-Pro in poly-L-proline type II helix conformation.

Aillard B, Kilburn JD, Blaydes JP, Tizzard GJ, Findlow S, Werner JM, Bloodworth S.

Org Biomol Chem. 2015 Apr 21;13(15):4562-9. doi: 10.1039/c5ob00180c.


Cancer-associated fibroblasts predict poor outcome and promote periostin-dependent invasion in oesophageal adenocarcinoma.

Underwood TJ, Hayden AL, Derouet M, Garcia E, Noble F, White MJ, Thirdborough S, Mead A, Clemons N, Mellone M, Uzoho C, Primrose JN, Blaydes JP, Thomas GJ.

J Pathol. 2015 Feb;235(3):466-77. doi: 10.1002/path.4467.


Transcription of click-linked DNA in human cells.

Birts CN, Sanzone AP, El-Sagheer AH, Blaydes JP, Brown T, Tavassoli A.

Angew Chem Int Ed Engl. 2014 Feb 24;53(9):2362-5. doi: 10.1002/anie.201308691. Epub 2014 Jan 22.


Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.

Eccles SA, Aboagye EO, Ali S, Anderson AS, Armes J, Berditchevski F, Blaydes JP, Brennan K, Brown NJ, Bryant HE, Bundred NJ, Burchell JM, Campbell AM, Carroll JS, Clarke RB, Coles CE, Cook GJ, Cox A, Curtin NJ, Dekker LV, Silva Idos S, Duffy SW, Easton DF, Eccles DM, Edwards DR, Edwards J, Evans D, Fenlon DF, Flanagan JM, Foster C, Gallagher WM, Garcia-Closas M, Gee JM, Gescher AJ, Goh V, Groves AM, Harvey AJ, Harvie M, Hennessy BT, Hiscox S, Holen I, Howell SJ, Howell A, Hubbard G, Hulbert-Williams N, Hunter MS, Jasani B, Jones LJ, Key TJ, Kirwan CC, Kong A, Kunkler IH, Langdon SP, Leach MO, Mann DJ, Marshall JF, Martin L, Martin SG, Macdougall JE, Miles DW, Miller WR, Morris JR, Moss SM, Mullan P, Natrajan R, O'Connor JP, O'Connor R, Palmieri C, Pharoah PD, Rakha EA, Reed E, Robinson SP, Sahai E, Saxton JM, Schmid P, Smalley MJ, Speirs V, Stein R, Stingl J, Streuli CH, Tutt AN, Velikova G, Walker RA, Watson CJ, Williams KJ, Young LS, Thompson AM.

Breast Cancer Res. 2013 Oct 1;15(5):R92. doi: 10.1186/bcr3493. Review.


Targeting tumour proliferation with a small-molecule inhibitor of AICAR transformylase homodimerization.

Spurr IB, Birts CN, Cuda F, Benkovic SJ, Blaydes JP, Tavassoli A.

Chembiochem. 2012 Jul 23;13(11):1628-34. doi: 10.1002/cbic.201200279. Epub 2012 Jul 4.


Down-regulation of DNA mismatch repair enhances initiation and growth of neuroblastoma and brain tumour multicellular spheroids.

Collins SL, Hervé R, Keevil CW, Blaydes JP, Webb JS.

PLoS One. 2011;6(12):e28123. doi: 10.1371/journal.pone.0028123. Epub 2011 Dec 1.


Selective anticancer activity of a hexapeptide with sequence homology to a non-kinase domain of Cyclin Dependent Kinase 4.

Warenius HM, Kilburn JD, Essex JW, Maurer RI, Blaydes JP, Agarwala U, Seabra LA.

Mol Cancer. 2011 Jun 13;10:72. doi: 10.1186/1476-4598-10-72.


CtBPs promote mitotic fidelity through their activities in the cell nucleus.

Birts CN, Bergman LM, Blaydes JP.

Oncogene. 2011 Mar 17;30(11):1272-80. doi: 10.1038/onc.2010.507. Epub 2010 Nov 8.


Expression of CtBP family protein isoforms in breast cancer and their role in chemoresistance.

Birts CN, Harding R, Soosaipillai G, Halder T, Azim-Araghi A, Darley M, Cutress RI, Bateman AC, Blaydes JP.

Biol Cell. 2010 Jan;103(1):1-19. doi: 10.1042/BC20100067.


A comparison of primary oesophageal squamous epithelial cells with HET-1A in organotypic culture.

Underwood TJ, Derouet MF, White MJ, Noble F, Moutasim KA, Smith E, Drew PA, Thomas GJ, Primrose JN, Blaydes JP.

Biol Cell. 2010 Dec;102(12):635-44. doi: 10.1042/BC20100071.


The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survival.

Wheater MJ, Johnson PW, Blaydes JP.

Cancer Biol Ther. 2010 Oct 1;10(7):728-35. doi: 10.4161/cbt.10.7.12965. Epub 2010 Oct 1.


HDMX-L is expressed from a functional p53-responsive promoter in the first intron of the HDMX gene and participates in an autoregulatory feedback loop to control p53 activity.

Phillips A, Teunisse A, Lam S, Lodder K, Darley M, Emaduddin M, Wolf A, Richter J, de Lange J, Verlaan-de Vries M, Lenos K, Böhnke A, Bartel F, Blaydes JP, Jochemsen AG.

J Biol Chem. 2010 Sep 17;285(38):29111-27. doi: 10.1074/jbc.M110.129726. Epub 2010 Jul 20.


CtBPs promote cell survival through the maintenance of mitotic fidelity.

Bergman LM, Birts CN, Darley M, Gabrielli B, Blaydes JP.

Mol Cell Biol. 2009 Aug;29(16):4539-51. doi: 10.1128/MCB.00439-09. Epub 2009 Jun 8.


Dissection of the functional interaction between p53 and the embryonic proto-oncoprotein PAX3.

Underwood TJ, Amin J, Lillycrop KA, Blaydes JP.

FEBS Lett. 2007 Dec 22;581(30):5831-5. Epub 2007 Nov 29.


MNK1 and EIF4E are downstream effectors of MEKs in the regulation of the nuclear export of HDM2 mRNA.

Phillips A, Blaydes JP.

Oncogene. 2008 Mar 6;27(11):1645-9. Epub 2007 Sep 10.


Role of the unique N-terminal domain of CtBP2 in determining the subcellular localisation of CtBP family proteins.

Bergman LM, Morris L, Darley M, Mirnezami AH, Gunatilake SC, Blaydes JP.

BMC Cell Biol. 2006 Sep 25;7:35.


Influence of the MDM2 single nucleotide polymorphism SNP309 on tumour development in BRCA1 mutation carriers.

Copson ER, White HE, Blaydes JP, Robinson DO, Johnson PW, Eccles DM.

BMC Cancer. 2006 Mar 24;6:80.


C-terminal binding proteins: emerging roles in cell survival and tumorigenesis.

Bergman LM, Blaydes JP.

Apoptosis. 2006 Jun;11(6):879-88. Review.


GC-selective DNA-binding antibiotic, mithramycin A, reveals multiple points of control in the regulation of Hdm2 protein synthesis.

Phillips A, Darley M, Blaydes JP.

Oncogene. 2006 Jul 13;25(30):4183-93. Epub 2006 Feb 27.


The mechanisms of regulation of Hdm2 protein level by serum growth factors.

Phillips A, Jones CJ, Blaydes JP.

FEBS Lett. 2006 Jan 9;580(1):300-4. Epub 2005 Dec 19.

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