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Results: 16

1.

Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses.

Dobrzyński M, Nguyen LK, Birtwistle MR, von Kriegsheim A, Blanco Fernández A, Cheong A, Kolch W, Kholodenko BN.

J R Soc Interface. 2014 Sep 6;11(98):20140383. doi: 10.1098/rsif.2014.0383.

PMID:
24966234
[PubMed - in process]
2.

Transcriptomes and shRNA Suppressors in a TP53 Allele-Specific Model of Early-Onset Colon Cancer in African Americans.

Weige CC, Birtwistle MR, Mallick H, Yi N, Berrong Z, Cloessner E, Duff K, Tidwell J, Clendenning M, Wilkerson B, Farrell C, Bunz F, Ji H, Shtutman M, Creek KE, Banister CE, Buckhaults PJ.

Mol Cancer Res. 2014 Jul;12(7):1029-41. doi: 10.1158/1541-7786.MCR-13-0286-T. Epub 2014 Apr 17.

PMID:
24743655
[PubMed - in process]
3.

Dimerization-based control of cooperativity.

Bouhaddou M, Birtwistle MR.

Mol Biosyst. 2014 Jul;10(7):1824-32. doi: 10.1039/c4mb00022f.

PMID:
24736836
[PubMed - in process]
4.

Evaluating strategies to normalise biological replicates of Western blot data.

Degasperi A, Birtwistle MR, Volinsky N, Rauch J, Kolch W, Kholodenko BN.

PLoS One. 2014 Jan 27;9(1):e87293. doi: 10.1371/journal.pone.0087293. eCollection 2014.

PMID:
24475266
[PubMed - in process]
Free PMC Article
5.

Mechanistic vs. Empirical network models of drug action.

Birtwistle MR, Mager DE, Gallo JM.

CPT Pharmacometrics Syst Pharmacol. 2013 Sep 6;2:e72. doi: 10.1038/psp.2013.51.

PMID:
24448020
[PubMed]
Free PMC Article
6.

A General Network Pharmacodynamic Model-Based Design Pipeline for Customized Cancer Therapy Applied to the VEGFR Pathway.

Zhang XY, Birtwistle MR, Gallo JM.

CPT Pharmacometrics Syst Pharmacol. 2014 Jan 15;3:e92. doi: 10.1038/psp.2013.65.

PMID:
24429593
[PubMed]
Free PMC Article
7.

Bayesian multivariate Poisson abundance models for T-cell receptor data.

Greene J, Birtwistle MR, Ignatowicz L, Rempala GA.

J Theor Biol. 2013 Jun 7;326:1-10. doi: 10.1016/j.jtbi.2013.02.009. Epub 2013 Mar 1.

PMID:
23467198
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Mammalian protein expression noise: scaling principles and the implications for knockdown experiments.

Birtwistle MR, von Kriegsheim A, Dobrzyński M, Kholodenko BN, Kolch W.

Mol Biosyst. 2012 Nov;8(11):3068-76. doi: 10.1039/c2mb25168j.

PMID:
22990612
[PubMed - indexed for MEDLINE]
9.

Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise.

Birtwistle MR, Rauch J, Kiyatkin A, Aksamitiene E, Dobrzyński M, Hoek JB, Kolch W, Ogunnaike BA, Kholodenko BN.

BMC Syst Biol. 2012 Aug 24;6:109. doi: 10.1186/1752-0509-6-109.

PMID:
22920937
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Novel somatic mutations to PI3K pathway genes in metastatic melanoma.

Shull AY, Latham-Schwark A, Ramasamy P, Leskoske K, Oroian D, Birtwistle MR, Buckhaults PJ.

PLoS One. 2012;7(8):e43369. doi: 10.1371/journal.pone.0043369. Epub 2012 Aug 17.

PMID:
22912864
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Linear approaches to intramolecular Förster resonance energy transfer probe measurements for quantitative modeling.

Birtwistle MR, von Kriegsheim A, Kida K, Schwarz JP, Anderson KI, Kolch W.

PLoS One. 2011;6(11):e27823. doi: 10.1371/journal.pone.0027823. Epub 2011 Nov 16.

PMID:
22114702
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Biology using engineering tools: the negative feedback amplifier.

Birtwistle MR, Kolch W.

Cell Cycle. 2011 Jul 1;10(13):2069-76. Epub 2011 Jul 1.

PMID:
21572255
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics.

Nakakuki T, Birtwistle MR, Saeki Y, Yumoto N, Ide K, Nagashima T, Brusch L, Ogunnaike BA, Okada-Hatakeyama M, Kholodenko BN.

Cell. 2010 May 28;141(5):884-96. doi: 10.1016/j.cell.2010.03.054. Epub 2010 May 20.

PMID:
20493519
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Four-dimensional dynamics of MAPK information processing systems.

Kholodenko BN, Birtwistle MR.

Wiley Interdiscip Rev Syst Biol Med. 2009 Jul-Aug;1(1):28-44. doi: 10.1002/wsbm.16. Review.

PMID:
20182652
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Endocytosis and signalling: a meeting with mathematics.

Birtwistle MR, Kholodenko BN.

Mol Oncol. 2009 Aug;3(4):308-20. doi: 10.1016/j.molonc.2009.05.009. Epub 2009 Jun 16. Review.

PMID:
19596615
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses.

Birtwistle MR, Hatakeyama M, Yumoto N, Ogunnaike BA, Hoek JB, Kholodenko BN.

Mol Syst Biol. 2007;3:144. Epub 2007 Nov 13.

PMID:
18004277
[PubMed - indexed for MEDLINE]
Free PMC Article

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