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Vaccine. 2011 May 12;29(21):3753-9. doi: 10.1016/j.vaccine.2011.03.035. Epub 2011 Apr 13.

Impact of rotavirus vaccination on hospitalizations for rotavirus diarrhea: the IVANHOE study.

Collaborators (162)

Chabarot A, Chevé A, Descourt JP, Gardach-Valeri C, Garnier-Diulein A, Hervochon JP, Legoff JY, Leguen E, Lescornet H, L'Hour M, Plouhinec C, Somerville D, Théau D, Tournade G, Varigny M, Beau F, Delaroche C, Guignot C, Le Bot C, Lefort MM, Lemanac'h MR, Mahé A, Mocquard J, Mongredien A, Pan-Lamande M, Ravary P, Schutzle ML, Agaiouedraogo E, Androuin E, Apprioual G, Ballan G, Barraine P, Bas O, Basse-Floc'hlay D, Basse A, Beau D, Bécam JC, Benic S, Bertault JC, Berthou Racca B, Billant Philippe C, Bleno P, Bouraya L, Bourillet C, Brelivet C, Bronnec P, Cabon L, Cadiou Meignen C, Cam F, Cam H, Cam-Pancher F, Cariou J, Cavarec Y, Coat-Gourio C, Crenn F, Crichen S, Criton M, Cueff N, De La Soudiere S, Derrien H, Derrien M, Disdier JP, Diserbo A, Doare C, Droff T, Duhamel S, Faucon C, Furet E, Gloanec I, Grall O, Grall X, Guérin H, Guermeur JJ, Guiard P, Havaux B, Hélou MF, Henry P, Houée P, Huchet D, Huyghues C, Jacob A, Jan A, Jézégou C, Jézégou H, Jézéquel F, Jouan P, Kapry M, Kergastel M, Kerivel B, Keriven H, Kermarec JC, Kermarrec P, le Paix KK, Knab N, Lagrosse J, Le Bars J, Le Berre V, Le Bris P, Le Cam-Bescond S, Le Clerc P, Le Corre P, Le Cossec T, Le Coz J, Le Foll J, Le Gall F, Le Goff Y, Le Hir A, Le Manac'h JY, Le Meur M, Le Page D, Le Pichon J, Le Rest JP, Le Stum P, Legrée E, L'Hostis MH, Houerou L, Liorzou D, Lossouarn M, Lossy N, Mahé J, Mathilin N, Mazars P, Mesguen D, Mingam P, Morizur A, Mouden J, Nerriec D, Pan JP, Parisot-Kille S, Pasquier B, Peden M, Pencole D, Philip A, Plouhinec B, Prigent D, Quemeneur M, Ratel D, Rivoal G, Robet L, Rolland Y, Roue JM, Rudelle P, Runavot G, Saout D, Scaliger D, Scaviner Mailloux N, Schollhammer N, Silliau E, Tanguy R, Taulois Leprince D, Têtu J, Tilly JF, Tran MA, Urcun M, Vicariot A, Viviere Robin MC, Watrin J, Garenne A, Giroux JD, Michel MP, Segura JF, Testa T.

Abstract

The aim of the IVANHOE study was to determine the real-world impact of the rotavirus vaccine, controlling for epidemic-to-epidemic variation in disease burden. A population-based prospective cohort study was conducted in Brest City and 7 suburban districts (CUB area), North-western Brittany, France (210,000 inhabitants; 5500 births per year). The vaccination program started in May 2007 for a 2-year period for all infants born in the Brest birth zone through pediatricians, public outpatient clinics and general practitioners. To determine vaccine impact we monitored trends in hospitalizations for rotavirus-specific diarrhea using an active hospital-based surveillance system initiated 5 years before vaccine introduction. The number of hospitalizations for rotavirus-specific diarrhea during the 2008/2009 epidemic in infants less than 2 years of age whose parents lived within the CUB area was modelled as a function of (1) the number of hospitalizations in infants 2-5 years of age to control for epidemic-to-epidemic variation and (2) vaccine introduction. A total of 4684 infants received at least one dose. Of these, 2635 lived within the CUB area. Vaccine coverage for a complete schedule in the CUB area was 47.1%. Poisson modelling revealed a reduction by a factor of 2.04 (1.56-2.66) in the number of hospitalizations during the last epidemic season (2008/2009), the number of observed cases being equal to 30, against an expected number of 61. Relative risk reduction for hospitalizations for rotavirus diarrhea was 98% (95% CI: 83-100%). We observed a noticeable impact of vaccination on rotavirus diarrhea hospitalizations within 2 years of vaccine introduction integrating for the first time rotavirus epidemics variation. The trial is registered with ClinicalTrials.gov, number, NCT00740935.

Copyright © 2011. Published by Elsevier Ltd.

PMID:
21443962
[PubMed - indexed for MEDLINE]
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