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Results: 1 to 20 of 72

1.

Molecular dynamics simulations of membrane proteins.

Biggin PC, Bond PJ.

Methods Mol Biol. 2015;1215:91-108. doi: 10.1007/978-1-4939-1465-4_5.

PMID:
25330960
[PubMed - in process]
2.

Agonist and Antagonist Binding in Human Glycine Receptors.

Yu R, Hurdiss E, Greiner T, Lape R, Sivilotti L, Biggin PC.

Biochemistry. 2014 Sep 15. [Epub ahead of print]

PMID:
25184435
[PubMed - as supplied by publisher]
3.

Non-equivalent ligand selectivity of agonist sites in (α4β2)2α4 nicotinic acetylcholine receptors: a key determinant of agonist efficacy.

Mazzaferro S, Gasparri F, New K, Alcaino C, Faundez M, Iturriaga Vasquez P, Vijayan R, Biggin PC, Bermudez I.

J Biol Chem. 2014 Aug 1;289(31):21795-806. doi: 10.1074/jbc.M114.555136. Epub 2014 Jun 16.

PMID:
24936069
[PubMed - in process]
4.

Towards understanding promiscuity in multidrug efflux pumps.

Wong K, Ma J, Rothnie A, Biggin PC, Kerr ID.

Trends Biochem Sci. 2014 Jan;39(1):8-16. doi: 10.1016/j.tibs.2013.11.002. Epub 2013 Dec 6. Review.

PMID:
24316304
[PubMed - indexed for MEDLINE]
5.

Toward an understanding of agonist binding to human Orexin-1 and Orexin-2 receptors with G-protein-coupled receptor modeling and site-directed mutagenesis.

Heifetz A, Barker O, Morris GB, Law RJ, Slack M, Biggin PC.

Biochemistry. 2013 Nov 19;52(46):8246-60. doi: 10.1021/bi401119m. Epub 2013 Nov 8.

PMID:
24144388
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

One Size Does Not Fit All: The Limits of Structure-Based Models in Drug Discovery.

Ross GA, Morris GM, Biggin PC.

J Chem Theory Comput. 2013 Sep 10;9(9):4266-4274. Epub 2013 Aug 5.

PMID:
24124403
[PubMed]
Free PMC Article
7.

Defining the structural relationship between kainate-receptor deactivation and desensitization.

Dawe GB, Musgaard M, Andrews ED, Daniels BA, Aurousseau MR, Biggin PC, Bowie D.

Nat Struct Mol Biol. 2013 Sep;20(9):1054-61. doi: 10.1038/nsmb.2654. Epub 2013 Aug 18.

PMID:
23955023
[PubMed - indexed for MEDLINE]
8.

Mutationmapper: a tool to aid the mapping of protein mutation data.

Vohra S, Biggin PC.

PLoS One. 2013 Aug 9;8(8):e71711. doi: 10.1371/journal.pone.0071711. eCollection 2013.

PMID:
23951226
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

The dynamics of camphor in the cytochrome P450 CYP101D2.

Vohra S, Musgaard M, Bell SG, Wong LL, Zhou W, Biggin PC.

Protein Sci. 2013 Sep;22(9):1218-29. doi: 10.1002/pro.2309. Epub 2013 Aug 12.

PMID:
23832606
[PubMed - in process]
Free PMC Article
10.

Mass spectrometry reveals synergistic effects of nucleotides, lipids, and drugs binding to a multidrug resistance efflux pump.

Marcoux J, Wang SC, Politis A, Reading E, Ma J, Biggin PC, Zhou M, Tao H, Zhang Q, Chang G, Morgner N, Robinson CV.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9704-9. doi: 10.1073/pnas.1303888110. Epub 2013 May 20.

PMID:
23690617
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Substrate versus inhibitor dynamics of P-glycoprotein.

Ma J, Biggin PC.

Proteins. 2013 Sep;81(9):1653-68. doi: 10.1002/prot.24324. Epub 2013 Jun 17.

PMID:
23670856
[PubMed - indexed for MEDLINE]
12.

The role of flexibility and conformational selection in the binding promiscuity of PDZ domains.

Münz M, Hein J, Biggin PC.

PLoS Comput Biol. 2012;8(11):e1002749. doi: 10.1371/journal.pcbi.1002749. Epub 2012 Nov 1.

PMID:
23133356
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Protein dynamics--a moving target: comment on "Comparing proteins by their internal dynamics: exploring structure-function relationships beyond static structural alignments" by C. Micheletti.

Biggin PC.

Phys Life Rev. 2013 Mar;10(1):27-8; discussion 39-40. doi: 10.1016/j.plrev.2012.10.005. Epub 2012 Oct 26. No abstract available.

PMID:
23122425
[PubMed - indexed for MEDLINE]
14.

An interview with Philip Biggin, Section Editor for Computational, in silico and modelling studies.

Biggin PC.

BMC Pharmacol Toxicol. 2012 Aug 13;13:2. doi: 10.1186/2050-6511-13-2. No abstract available.

PMID:
22947036
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Study of human Orexin-1 and -2 G-protein-coupled receptors with novel and published antagonists by modeling, molecular dynamics simulations, and site-directed mutagenesis.

Heifetz A, Morris GB, Biggin PC, Barker O, Fryatt T, Bentley J, Hallett D, Manikowski D, Pal S, Reifegerste R, Slack M, Law R.

Biochemistry. 2012 Apr 17;51(15):3178-97. doi: 10.1021/bi300136h. Epub 2012 Apr 5.

PMID:
22448975
[PubMed - indexed for MEDLINE]
16.

Rapid and accurate prediction and scoring of water molecules in protein binding sites.

Ross GA, Morris GM, Biggin PC.

PLoS One. 2012;7(3):e32036. doi: 10.1371/journal.pone.0032036. Epub 2012 Mar 1.

PMID:
22396746
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

JGromacs: a Java package for analyzing protein simulations.

Münz M, Biggin PC.

J Chem Inf Model. 2012 Jan 23;52(1):255-9. doi: 10.1021/ci200289s. Epub 2012 Jan 9.

PMID:
22191855
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Chloride ions in the pore of glycine and GABA channels shape the time course and voltage dependence of agonist currents.

Moroni M, Biro I, Giugliano M, Vijayan R, Biggin PC, Beato M, Sivilotti LG.

J Neurosci. 2011 Oct 5;31(40):14095-106. doi: 10.1523/JNEUROSCI.1985-11.2011.

PMID:
21976494
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Additional acetylcholine (ACh) binding site at alpha4/alpha4 interface of (alpha4beta2)2alpha4 nicotinic receptor influences agonist sensitivity.

Mazzaferro S, Benallegue N, Carbone A, Gasparri F, Vijayan R, Biggin PC, Moroni M, Bermudez I.

J Biol Chem. 2011 Sep 2;286(35):31043-54. doi: 10.1074/jbc.M111.262014. Epub 2011 Jul 14.

PMID:
21757735
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

The influence of different lipid environments on the structure and function of the hepatitis C virus p7 ion channel protein.

Whitfield T, Miles AJ, Scheinost JC, Offer J, Wentworth P Jr, Dwek RA, Wallace BA, Biggin PC, Zitzmann N.

Mol Membr Biol. 2011 Aug;28(5):254-64. doi: 10.3109/09687688.2011.581253. Epub 2011 May 23.

PMID:
21604991
[PubMed - indexed for MEDLINE]

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