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Items: 1 to 20 of 87

1.

A Numbering System for MFS Transporter Proteins.

Lee J, Sands ZA, Biggin PC.

Front Mol Biosci. 2016 Jun 2;3:21. doi: 10.3389/fmolb.2016.00021. eCollection 2016.

2.

Using the fragment molecular orbital method to investigate agonist-orexin-2 receptor interactions.

Heifetz A, Aldeghi M, Chudyk EI, Fedorov DG, Bodkin MJ, Biggin PC.

Biochem Soc Trans. 2016 Apr 15;44(2):574-81. doi: 10.1042/BST20150250. Review.

PMID:
27068972
3.

Distinct Structural Pathways Coordinate the Activation of AMPA Receptor-Auxiliary Subunit Complexes.

Dawe GB, Musgaard M, Aurousseau MR, Nayeem N, Green T, Biggin PC, Bowie D.

Neuron. 2016 Mar 16;89(6):1264-76. doi: 10.1016/j.neuron.2016.01.038. Epub 2016 Feb 25.

4.

Application of an Integrated GPCR SAR-Modeling Platform To Explain the Activation Selectivity of Human 5-HT2C over 5-HT2B.

Heifetz A, Storer RI, McMurray G, James T, Morao I, Aldeghi M, Bodkin MJ, Biggin PC.

ACS Chem Biol. 2016 May 20;11(5):1372-82. doi: 10.1021/acschembio.5b01045. Epub 2016 Mar 7.

PMID:
26900768
5.

Accurate calculation of the absolute free energy of binding for drug molecules.

Aldeghi M, Heifetz A, Bodkin MJ, Knapp S, Biggin PC.

Chem Sci. 2016 Jan 14;7(1):207-218. Epub 2015 Oct 7.

6.

Role of an Absolutely Conserved Tryptophan Pair in the Extracellular Domain of Cys-Loop Receptors.

Braun N, Lynagh T, Yu R, Biggin PC, Pless SA.

ACS Chem Neurosci. 2016 Mar 16;7(3):339-48. doi: 10.1021/acschemneuro.5b00298. Epub 2016 Jan 29.

PMID:
26764897
7.

Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.

Fedorov O, Castex J, Tallant C, Owen DR, Martin S, Aldeghi M, Monteiro O, Filippakopoulos P, Picaud S, Trzupek JD, Gerstenberger BS, Bountra C, Willmann D, Wells C, Philpott M, Rogers C, Biggin PC, Brennan PE, Bunnage ME, Schüle R, Günther T, Knapp S, Müller S.

Sci Adv. 2015 Nov 13;1(10):e1500723. doi: 10.1126/sciadv.1500723. eCollection 2015 Nov.

8.

Kainate receptor pore-forming and auxiliary subunits regulate channel block by a novel mechanism.

Brown PM, Aurousseau MR, Musgaard M, Biggin PC, Bowie D.

J Physiol. 2016 Apr 1;594(7):1821-40. doi: 10.1113/JP271690. Epub 2016 Feb 2.

PMID:
26682513
9.

On the atomic structure of cocaine in solution.

Johnston AJ, Busch S, Pardo LC, Callear SK, Biggin PC, McLain SE.

Phys Chem Chem Phys. 2016 Jan 14;18(2):991-9. doi: 10.1039/c5cp06090g.

PMID:
26660073
10.

The Fragment Molecular Orbital Method Reveals New Insight into the Chemical Nature of GPCR-Ligand Interactions.

Heifetz A, Chudyk EI, Gleave L, Aldeghi M, Cherezov V, Fedorov DG, Biggin PC, Bodkin MJ.

J Chem Inf Model. 2016 Jan 25;56(1):159-72. doi: 10.1021/acs.jcim.5b00644. Epub 2015 Dec 24.

PMID:
26642258
11.

Homology modelling of human P-glycoprotein.

Domicevica L, Biggin PC.

Biochem Soc Trans. 2015 Oct;43(5):952-8. doi: 10.1042/BST20150125. Review.

PMID:
26517909
12.

Discovery of the First Selective, Nonpeptidic Orexin 2 Receptor Agonists.

Heifetz A, Bodkin MJ, Biggin PC.

J Med Chem. 2015 Oct 22;58(20):7928-30. doi: 10.1021/acs.jmedchem.5b01394. Epub 2015 Sep 16.

PMID:
26375584
13.

Position and orientational preferences of drug-like compounds in lipid membranes: a computational and NMR approach.

Ma J, Domicevica L, Schnell JR, Biggin PC.

Phys Chem Chem Phys. 2015 Aug 14;17(30):19766-76. doi: 10.1039/c5cp03218k.

PMID:
26153345
14.

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014.

Heifetz A, Schertler GF, Seifert R, Tate CG, Sexton PM, Gurevich VV, Fourmy D, Cherezov V, Marshall FH, Storer RI, Moraes I, Tikhonova IG, Tautermann CS, Hunt P, Ceska T, Hodgson S, Bodkin MJ, Singh S, Law RJ, Biggin PC.

Naunyn Schmiedebergs Arch Pharmacol. 2015 Aug;388(8):883-903. doi: 10.1007/s00210-015-1111-8. Epub 2015 Mar 14.

15.

Exploring the interaction of SV2A with racetams using homology modelling, molecular dynamics and site-directed mutagenesis.

Lee J, Daniels V, Sands ZA, Lebon F, Shi J, Biggin PC.

PLoS One. 2015 Feb 18;10(2):e0116589. doi: 10.1371/journal.pone.0116589. eCollection 2015.

16.

Molecular dynamics simulations of membrane proteins.

Biggin PC, Bond PJ.

Methods Mol Biol. 2015;1215:91-108. doi: 10.1007/978-1-4939-1465-4_5.

PMID:
25330960
17.

Agonist and antagonist binding in human glycine receptors.

Yu R, Hurdiss E, Greiner T, Lape R, Sivilotti L, Biggin PC.

Biochemistry. 2014 Sep 30;53(38):6041-51. doi: 10.1021/bi500815f. Epub 2014 Sep 15.

PMID:
25184435
18.

Non-equivalent ligand selectivity of agonist sites in (α4β2)2α4 nicotinic acetylcholine receptors: a key determinant of agonist efficacy.

Mazzaferro S, Gasparri F, New K, Alcaino C, Faundez M, Iturriaga Vasquez P, Vijayan R, Biggin PC, Bermudez I.

J Biol Chem. 2014 Aug 1;289(31):21795-806. doi: 10.1074/jbc.M114.555136. Epub 2014 Jun 16.

19.

Towards understanding promiscuity in multidrug efflux pumps.

Wong K, Ma J, Rothnie A, Biggin PC, Kerr ID.

Trends Biochem Sci. 2014 Jan;39(1):8-16. doi: 10.1016/j.tibs.2013.11.002. Epub 2013 Dec 6. Review.

PMID:
24316304
20.

Toward an understanding of agonist binding to human Orexin-1 and Orexin-2 receptors with G-protein-coupled receptor modeling and site-directed mutagenesis.

Heifetz A, Barker O, Morris GB, Law RJ, Slack M, Biggin PC.

Biochemistry. 2013 Nov 19;52(46):8246-60. doi: 10.1021/bi401119m. Epub 2013 Nov 8.

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