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Results: 1 to 20 of 113


Chromatin at the nuclear periphery and the regulation of genome functions.

Lemaître C, Bickmore WA.

Histochem Cell Biol. 2015 Jul 14. [Epub ahead of print]


A TAD Closer to Understanding Dosage Compensation.

Wood AJ, Bickmore WA.

Dev Cell. 2015 Jun 8;33(5):498-9. doi: 10.1016/j.devcel.2015.05.021.


Spatial genome organization: contrasting views from chromosome conformation capture and fluorescence in situ hybridization.

Williamson I, Berlivet S, Eskeland R, Boyle S, Illingworth RS, Paquette D, Dostie J, Bickmore WA.

Genes Dev. 2014 Dec 15;28(24):2778-91. doi: 10.1101/gad.251694.114.


Chromatin decondensation is sufficient to alter nuclear organization in embryonic stem cells.

Therizols P, Illingworth RS, Courilleau C, Boyle S, Wood AJ, Bickmore WA.

Science. 2014 Dec 5;346(6214):1238-42. doi: 10.1126/science.1259587.


Psip1/Ledgf p75 restrains Hox gene expression by recruiting both trithorax and polycomb group proteins.

Pradeepa MM, Grimes GR, Taylor GC, Sutherland HG, Bickmore WA.

Nucleic Acids Res. 2014 Aug;42(14):9021-32. doi: 10.1093/nar/gku647. Epub 2014 Jul 23.


PRC2-independent chromatin compaction and transcriptional repression in cancer.

Vallot C, Hérault A, Boyle S, Bickmore WA, Radvanyi F.

Oncogene. 2015 Feb 5;34(6):741-51. doi: 10.1038/onc.2013.604. Epub 2014 Jan 27.


H4K16 acetylation marks active genes and enhancers of embryonic stem cells, but does not alter chromatin compaction.

Taylor GC, Eskeland R, Hekimoglu-Balkan B, Pradeepa MM, Bickmore WA.

Genome Res. 2013 Dec;23(12):2053-65. doi: 10.1101/gr.155028.113. Epub 2013 Aug 29.


Transcription. Flashing a light on the spatial organization of transcription.

Rickman C, Bickmore WA.

Science. 2013 Aug 9;341(6146):621-2. doi: 10.1126/science.1242889. No abstract available.


The spatial organization of the human genome.

Bickmore WA.

Annu Rev Genomics Hum Genet. 2013;14:67-84. doi: 10.1146/annurev-genom-091212-153515. Epub 2013 Jul 15. Review.


FGF signalling regulates chromatin organisation during neural differentiation via mechanisms that can be uncoupled from transcription.

Patel NS, Rhinn M, Semprich CI, Halley PA, Dollé P, Bickmore WA, Storey KG.

PLoS Genet. 2013;9(7):e1003614. doi: 10.1371/journal.pgen.1003614. Epub 2013 Jul 18.


Regional chromatin decompaction in Cornelia de Lange syndrome associated with NIPBL disruption can be uncoupled from cohesin and CTCF.

Nolen LD, Boyle S, Ansari M, Pritchard E, Bickmore WA.

Hum Mol Genet. 2013 Oct 15;22(20):4180-93. doi: 10.1093/hmg/ddt265. Epub 2013 Jun 10.


Divergence of mammalian higher order chromatin structure is associated with developmental loci.

Chambers EV, Bickmore WA, Semple CA.

PLoS Comput Biol. 2013 Apr;9(4):e1003017. doi: 10.1371/journal.pcbi.1003017. Epub 2013 Apr 4.


Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes.

Reddington JP, Perricone SM, Nestor CE, Reichmann J, Youngson NA, Suzuki M, Reinhardt D, Dunican DS, Prendergast JG, Mjoseng H, Ramsahoye BH, Whitelaw E, Greally JM, Adams IR, Bickmore WA, Meehan RR.

Genome Biol. 2013 Mar 25;14(3):R25. doi: 10.1186/gb-2013-14-3-r25.


Single-cell dynamics of genome-nuclear lamina interactions.

Kind J, Pagie L, Ortabozkoyun H, Boyle S, de Vries SS, Janssen H, Amendola M, Nolen LD, Bickmore WA, van Steensel B.

Cell. 2013 Mar 28;153(1):178-92. doi: 10.1016/j.cell.2013.02.028. Epub 2013 Mar 21.


Genome architecture: domain organization of interphase chromosomes.

Bickmore WA, van Steensel B.

Cell. 2013 Mar 14;152(6):1270-84. doi: 10.1016/j.cell.2013.02.001. Review.


Specific nuclear envelope transmembrane proteins can promote the location of chromosomes to and from the nuclear periphery.

Zuleger N, Boyle S, Kelly DA, de las Heras JI, Lazou V, Korfali N, Batrakou DG, Randles KN, Morris GE, Harrison DJ, Bickmore WA, Schirmer EC.

Genome Biol. 2013 Feb 15;14(2):R14. doi: 10.1186/gb-2013-14-2-r14.


Genomics: ENCODE explained.

Ecker JR, Bickmore WA, Barroso I, Pritchard JK, Gilad Y, Segal E.

Nature. 2012 Sep 6;489(7414):52-5. doi: 10.1038/489052a. No abstract available.


Anterior-posterior differences in HoxD chromatin topology in limb development.

Williamson I, Eskeland R, Lettice LA, Hill AE, Boyle S, Grimes GR, Hill RE, Bickmore WA.

Development. 2012 Sep;139(17):3157-67. doi: 10.1242/dev.081174.


Histone H2A mono-ubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identity.

Endoh M, Endo TA, Endoh T, Isono K, Sharif J, Ohara O, Toyoda T, Ito T, Eskeland R, Bickmore WA, Vidal M, Bernstein BE, Koseki H.

PLoS Genet. 2012;8(7):e1002774. doi: 10.1371/journal.pgen.1002774. Epub 2012 Jul 26.


Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing.

Pradeepa MM, Sutherland HG, Ule J, Grimes GR, Bickmore WA.

PLoS Genet. 2012;8(5):e1002717. doi: 10.1371/journal.pgen.1002717. Epub 2012 May 17.

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