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Toxicity of Amphotericin B Deoxycholate-Based Induction Therapy in Patients with HIV-Associated Cryptococcal Meningitis.

Bicanic T, Bottomley C, Loyse A, Brouwer AE, Muzoora C, Taseera K, Jackson A, Phulusa J, Hosseinipour MC, van der Horst C, Limmathurotsakul D, White NJ, Wilson D, Wood R, Meintjes G, Harrison TS, Jarvis JN.

Antimicrob Agents Chemother. 2015 Dec;59(12):7224-31. doi: 10.1128/AAC.01698-15. Epub 2015 Sep 8.


Genotypic Diversity Is Associated with Clinical Outcome and Phenotype in Cryptococcal Meningitis across Southern Africa.

Beale MA, Sabiiti W, Robertson EJ, Fuentes-Cabrejo KM, O'Hanlon SJ, Jarvis JN, Loyse A, Meintjes G, Harrison TS, May RC, Fisher MC, Bicanic T.

PLoS Negl Trop Dis. 2015 Jun 25;9(6):e0003847. doi: 10.1371/journal.pntd.0003847. eCollection 2015 Jun.


Cerebrospinal fluid cytokine profiles predict risk of early mortality and immune reconstitution inflammatory syndrome in HIV-associated cryptococcal meningitis.

Jarvis JN, Meintjes G, Bicanic T, Buffa V, Hogan L, Mo S, Tomlinson G, Kropf P, Noursadeghi M, Harrison TS.

PLoS Pathog. 2015 Apr 8;11(4):e1004754. doi: 10.1371/journal.ppat.1004754. eCollection 2015 Apr.


Microrheology with optical tweezers: measuring the relative viscosity of solutions 'at a glance'.

Tassieri M, Del Giudice F, Robertson EJ, Jain N, Fries B, Wilson R, Glidle A, Greco F, Netti PA, Maffettone PL, Bicanic T, Cooper JM.

Sci Rep. 2015 Mar 6;5:8831. doi: 10.1038/srep08831.


Neurological, visual, and MRI brain scan findings in 87 South African patients with HIV-associated cryptococcal meningoencephalitis.

Loyse A, Moodley A, Rich P, Molloy SF, Bicanic T, Bishop L, Rae WI, Bhigjee AI, Loubser ND, Michowicz AJ, Wilson D, Harrison TS.

J Infect. 2015 Jun;70(6):668-75. doi: 10.1016/j.jinf.2014.10.007. Epub 2014 Oct 22.


Treatment principles for Candida and Cryptococcus.

Whitney LC, Bicanic T.

Cold Spring Harb Perspect Med. 2014 Nov 10;5(6). pii: a024158. doi: 10.1101/cshperspect.a024158. Review.


Cryptococcosis diagnosis and treatment: What do we know now.

Perfect JR, Bicanic T.

Fungal Genet Biol. 2015 May;78:49-54. doi: 10.1016/j.fgb.2014.10.003. Epub 2014 Oct 13.


Very low levels of 25-hydroxyvitamin D are not associated with immunologic changes or clinical outcome in South African patients with HIV-associated cryptococcal meningitis.

Jarvis JN, Bicanic T, Loyse A, Meintjes G, Hogan L, Roberts CH, Shoham S, Perfect JR, Govender NP, Harrison TS.

Clin Infect Dis. 2014 Aug 15;59(4):493-500. doi: 10.1093/cid/ciu349. Epub 2014 May 13.


Access to antifungal medicines in resource-poor countries - authors' reply.

Loyse A, Thangaraj H, Govender NP, Harrison T, Bicanic T; all authors.

Lancet Infect Dis. 2014 May;14(5):371. doi: 10.1016/S1473-3099(14)70068-4. No abstract available.


Efficient phagocytosis and laccase activity affect the outcome of HIV-associated cryptococcosis.

Sabiiti W, Robertson E, Beale MA, Johnston SA, Brouwer AE, Loyse A, Jarvis JN, Gilbert AS, Fisher MC, Harrison TS, May RC, Bicanic T.

J Clin Invest. 2014 May;124(5):2000-8. doi: 10.1172/JCI72950. Epub 2014 Apr 17.


AIDS-related mycoses: the way forward.

Brown GD, Meintjes G, Kolls JK, Gray C, Horsnell W; Working Group from the EMBO-AIDS Related Mycoses Workshop, Achan B, Alber G, Aloisi M, Armstrong-James D, Beale M, Bicanic T, Black J, Bohjanen P, Botes A, Boulware DR, Brown G, Bunjun R, Carr W, Casadevall A, Chang C, Chivero E, Corcoran C, Cross A, Dawood H, Day J, De Bernardis F, De Jager V, De Repentigny L, Denning D, Eschke M, Finkelman M, Govender N, Gow N, Graham L, Gryschek R, Hammond-Aryee K, Harrison T, Heard N, Hill M, Hoving JC, Janoff E, Jarvis J, Kayuni S, King K, Kolls J, Kullberg BJ, Lalloo DG, Letang E, Levitz S, Limper A, Longley N, Machiridza TR, Mahabeer Y, Martinsons N, Meiring S, Meya D, Miller R, Molloy S, Morris L, Mukaremera L, Musubire AK, Muzoora C, Nair A, Nakiwala Kimbowa J, Netea M, Nielsen K, O'hern J, Okurut S, Parker A, Patterson T, Pennap G, Perfect J, Prinsloo C, Rhein J, Rolfes MA, Samuel C, Schutz C, Scriven J, Sebolai OM, Sojane K, Sriruttan C, Stead D, Steyn A, Thawer NK, Thienemann F, Von Hohenberg M, Vreulink JM, Wessels J, Wood K, Yang YL.

Trends Microbiol. 2014 Mar;22(3):107-9. doi: 10.1016/j.tim.2013.12.008.


The Cryptococcus neoformans transcriptome at the site of human meningitis.

Chen Y, Toffaletti DL, Tenor JL, Litvintseva AP, Fang C, Mitchell TG, McDonald TR, Nielsen K, Boulware DR, Bicanic T, Perfect JR.

MBio. 2014 Feb 4;5(1):e01087-13. doi: 10.1128/mBio.01087-13.


Determinants of mortality in a combined cohort of 501 patients with HIV-associated Cryptococcal meningitis: implications for improving outcomes.

Jarvis JN, Bicanic T, Loyse A, Namarika D, Jackson A, Nussbaum JC, Longley N, Muzoora C, Phulusa J, Taseera K, Kanyembe C, Wilson D, Hosseinipour MC, Brouwer AE, Limmathurotsakul D, White N, van der Horst C, Wood R, Meintjes G, Bradley J, Jaffar S, Harrison T.

Clin Infect Dis. 2014 Mar;58(5):736-45. doi: 10.1093/cid/cit794. Epub 2013 Dec 6.


Cryptococcus neoformans ex vivo capsule size is associated with intracranial pressure and host immune response in HIV-associated cryptococcal meningitis.

Robertson EJ, Najjuka G, Rolfes MA, Akampurira A, Jain N, Anantharanjit J, von Hohenberg M, Tassieri M, Carlsson A, Meya DB, Harrison TS, Fries BC, Boulware DR, Bicanic T.

J Infect Dis. 2014 Jan 1;209(1):74-82. doi: 10.1093/infdis/jit435. Epub 2013 Aug 14.


Combination antifungal therapy for cryptococcal meningitis.

Loyse A, Bicanic T, Jarvis JN.

N Engl J Med. 2013 Jun 27;368(26):2522. doi: 10.1056/NEJMc1305981#SA1. No abstract available.


Cryptococcal meningitis: improving access to essential antifungal medicines in resource-poor countries.

Loyse A, Thangaraj H, Easterbrook P, Ford N, Roy M, Chiller T, Govender N, Harrison TS, Bicanic T.

Lancet Infect Dis. 2013 Jul;13(7):629-37. doi: 10.1016/S1473-3099(13)70078-1. Epub 2013 Jun 2. Review.


British HIV Association opportunistic infection guidelines: in defence of amphotericin B deoxycholate.

Bicanic T, Ogden D, Whitney L, Loyse A, Jarvis J.

HIV Med. 2012 Nov;13(10):636-7. doi: 10.1111/j.1468-1293.2012.01022.x. No abstract available.


The prevalence of cryptococcal antigenemia in newly diagnosed HIV patients in a Southwest London cohort.

Patel S, Shin GY, Wijewardana I, Vitharana SR, Cormack I, Pakianathan M, Harrison TS, Bicanic T.

J Infect. 2013 Jan;66(1):75-9. doi: 10.1016/j.jinf.2012.09.014. Epub 2012 Oct 6.


Adjunctive interferon-γ immunotherapy for the treatment of HIV-associated cryptococcal meningitis: a randomized controlled trial.

Jarvis JN, Meintjes G, Rebe K, Williams GN, Bicanic T, Williams A, Schutz C, Bekker LG, Wood R, Harrison TS.

AIDS. 2012 Jun 1;26(9):1105-13. doi: 10.1097/QAD.0b013e3283536a93.


Comparison of the early fungicidal activity of high-dose fluconazole, voriconazole, and flucytosine as second-line drugs given in combination with amphotericin B for the treatment of HIV-associated cryptococcal meningitis.

Loyse A, Wilson D, Meintjes G, Jarvis JN, Bicanic T, Bishop L, Rebe K, Williams A, Jaffar S, Bekker LG, Wood R, Harrison TS.

Clin Infect Dis. 2012 Jan 1;54(1):121-8. doi: 10.1093/cid/cir745. Epub 2011 Nov 3.

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