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Results: 1 to 20 of 21

1.

Retrospective study of a TTR FAP cohort to modify NIS+7 for therapeutic trials.

Suanprasert N, Berk JL, Benson MD, Dyck PJ, Klein CJ, Gollob JA, Bettencourt BR, Karsten V, Dyck PJ.

J Neurol Sci. 2014 Sep 15;344(1-2):121-8. doi: 10.1016/j.jns.2014.06.041. Epub 2014 Jun 27.

PMID:
25012480
2.

Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial.

Fitzgerald K, Frank-Kamenetsky M, Shulga-Morskaya S, Liebow A, Bettencourt BR, Sutherland JE, Hutabarat RM, Clausen VA, Karsten V, Cehelsky J, Nochur SV, Kotelianski V, Horton J, Mant T, Chiesa J, Ritter J, Munisamy M, Vaishnaw AK, Gollob JA, Simon A.

Lancet. 2014 Jan 4;383(9911):60-8. doi: 10.1016/S0140-6736(13)61914-5. Epub 2013 Oct 3.

3.

Safety and efficacy of RNAi therapy for transthyretin amyloidosis.

Coelho T, Adams D, Silva A, Lozeron P, Hawkins PN, Mant T, Perez J, Chiesa J, Warrington S, Tranter E, Munisamy M, Falzone R, Harrop J, Cehelsky J, Bettencourt BR, Geissler M, Butler JS, Sehgal A, Meyers RE, Chen Q, Borland T, Hutabarat RM, Clausen VA, Alvarez R, Fitzgerald K, Gamba-Vitalo C, Nochur SV, Vaishnaw AK, Sah DW, Gollob JA, Suhr OB.

N Engl J Med. 2013 Aug 29;369(9):819-29. doi: 10.1056/NEJMoa1208760.

4.

An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia.

Schmidt PJ, Toudjarska I, Sendamarai AK, Racie T, Milstein S, Bettencourt BR, Hettinger J, Bumcrot D, Fleming MD.

Blood. 2013 Feb 14;121(7):1200-8. doi: 10.1182/blood-2012-09-453977. Epub 2012 Dec 6.

5.

Organization and evolution of hsp70 clusters strikingly differ in two species of Stratiomyidae (Diptera) inhabiting thermally contrasting environments.

Garbuz DG, Yushenova IA, Zatsepina OG, Przhiboro AA, Bettencourt BR, Evgen'ev MB.

BMC Evol Biol. 2011 Mar 22;11:74. doi: 10.1186/1471-2148-11-74.

6.

Natural variation of the amino-terminal glutamine-rich domain in Drosophila argonaute2 is not associated with developmental defects.

Hain D, Bettencourt BR, Okamura K, Csorba T, Meyer W, Jin Z, Biggerstaff J, Siomi H, Hutvagner G, Lai EC, Welte M, Müller HA.

PLoS One. 2010 Dec 17;5(12):e15264. doi: 10.1371/journal.pone.0015264.

7.

In vivo quantification of formulated and chemically modified small interfering RNA by heating-in-Triton quantitative reverse transcription polymerase chain reaction (HIT qRT-PCR).

Landesman Y, Svrzikapa N, Cognetta A 3rd, Zhang X, Bettencourt BR, Kuchimanchi S, Dufault K, Shaikh S, Gioia M, Akinc A, Hutabarat R, Meyers R.

Silence. 2010 Aug 23;1(1):16. doi: 10.1186/1758-907X-1-16.

8.

Duplicate gene evolution toward multiple fates at the Drosophila melanogaster HIP/HIP-Replacement locus.

Hogan CC, Bettencourt BR.

J Mol Evol. 2009 Apr;68(4):337-50. doi: 10.1007/s00239-009-9213-x. Epub 2009 Mar 31.

PMID:
19333534
9.

Natural variation in Drosophila stressed locomotion meets or exceeds variation caused by hsp70 mutation: analysis of behavior and performance.

Bettencourt BR, Drohan BW, Ireland AT, Santhanam M, Smrtic MB, Sullivan EM.

Behav Genet. 2009 May;39(3):306-20. doi: 10.1007/s10519-009-9256-1. Epub 2009 Feb 26.

PMID:
19242787
11.

Polyglutamine expansion in Drosophila: thermal stress and Hsp70 as selective agents.

Bettencourt BR, Hogan CC, Nimali M.

J Biosci. 2007 Apr;32(3):537-47. Review.

13.

Comparative genome sequencing of Drosophila pseudoobscura: chromosomal, gene, and cis-element evolution.

Richards S, Liu Y, Bettencourt BR, Hradecky P, Letovsky S, Nielsen R, Thornton K, Hubisz MJ, Chen R, Meisel RP, Couronne O, Hua S, Smith MA, Zhang P, Liu J, Bussemaker HJ, van Batenburg MF, Howells SL, Scherer SE, Sodergren E, Matthews BB, Crosby MA, Schroeder AJ, Ortiz-Barrientos D, Rives CM, Metzker ML, Muzny DM, Scott G, Steffen D, Wheeler DA, Worley KC, Havlak P, Durbin KJ, Egan A, Gill R, Hume J, Morgan MB, Miner G, Hamilton C, Huang Y, Waldron L, Verduzco D, Clerc-Blankenburg KP, Dubchak I, Noor MA, Anderson W, White KP, Clark AG, Schaeffer SW, Gelbart W, Weinstock GM, Gibbs RA.

Genome Res. 2005 Jan;15(1):1-18.

14.

Compensated deleterious mutations in insect genomes.

Kulathinal RJ, Bettencourt BR, Hartl DL.

Science. 2004 Nov 26;306(5701):1553-4. Epub 2004 Oct 21.

15.

Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.

Misra S, Crosby MA, Mungall CJ, Matthews BB, Campbell KS, Hradecky P, Huang Y, Kaminker JS, Millburn GH, Prochnik SE, Smith CD, Tupy JL, Whitfied EJ, Bayraktaroglu L, Berman BP, Bettencourt BR, Celniker SE, de Grey AD, Drysdale RA, Harris NL, Richter J, Russo S, Schroeder AJ, Shu SQ, Stapleton M, Yamada C, Ashburner M, Gelbart WM, Rubin GM, Lewis SE.

Genome Biol. 2002;3(12):RESEARCH0083. Epub 2002 Dec 31. Review.

16.

Modification of heat-shock gene expression in Drosophila melanogaster populations via transposable elements.

Lerman DN, Michalak P, Helin AB, Bettencourt BR, Feder ME.

Mol Biol Evol. 2003 Jan;20(1):135-44.

17.

Response to natural and laboratory selection at the Drosophila hsp70 genes.

Bettencourt BR, Kim I, Hoffmann AA, Feder ME.

Evolution. 2002 Sep;56(9):1796-801.

PMID:
12389724
18.

Rapid concerted evolution via gene conversion at the Drosophila hsp70 genes.

Bettencourt BR, Feder ME.

J Mol Evol. 2002 May;54(5):569-86.

PMID:
11965431
19.

Genetic evidence for adaptation-driven incipient speciation of Drosophila melanogaster along a microclimatic contrast in "Evolution Canyon," Israel.

Michalak P, Minkov I, Helin A, Lerman DN, Bettencourt BR, Feder ME, Korol AB, Nevo E.

Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13195-200. Epub 2001 Oct 30.

20.

A Drosophila melanogaster strain from sub-equatorial Africa has exceptional thermotolerance but decreased Hsp70 expression.

Zatsepina OG, Velikodvorskaia VV, Molodtsov VB, Garbuz D, Lerman DN, Bettencourt BR, Feder ME, Evgenev MB.

J Exp Biol. 2001 Jun;204(Pt 11):1869-81.

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