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Results: 1 to 20 of 25

1.

Proposal for a "phase II" multicenter trial model for preclinical new antiepilepsy therapy development.

O'Brien TJ, Ben-Menachem E, Bertram EH 3rd, Collins SD, Kokaia M, Lerche H, Klitgaard H, Staley KJ, Vaudano E, Walker MC, Simonato M.

Epilepsia. 2013 Aug;54 Suppl 4:70-4. doi: 10.1111/epi.12300. Review.

PMID:
23909855
[PubMed - indexed for MEDLINE]
2.

Epilepsy biomarkers.

Engel J Jr, Pitkänen A, Loeb JA, Dudek FE, Bertram EH 3rd, Cole AJ, Moshé SL, Wiebe S, Jensen FE, Mody I, Nehlig A, Vezzani A.

Epilepsia. 2013 Aug;54 Suppl 4:61-9. doi: 10.1111/epi.12299. Review.

PMID:
23909854
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Evidence for a role of Nav1.6 in facilitating increases in neuronal hyperexcitability during epileptogenesis.

Hargus NJ, Nigam A, Bertram EH 3rd, Patel MK.

J Neurophysiol. 2013 Sep;110(5):1144-57. doi: 10.1152/jn.00383.2013. Epub 2013 Jun 5.

PMID:
23741036
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Identification of new epilepsy treatments: issues in preclinical methodology.

Galanopoulou AS, Buckmaster PS, Staley KJ, Moshé SL, Perucca E, Engel J Jr, Löscher W, Noebels JL, Pitkänen A, Stables J, White HS, O'Brien TJ, Simonato M; American Epilepsy Society Basic Science Committee And The International League Against Epilepsy Working Group On Recommendations For Preclinical Epilepsy Drug Discovery.

Epilepsia. 2012 Mar;53(3):571-82. doi: 10.1111/j.1528-1167.2011.03391.x. Epub 2012 Jan 31. Review.

PMID:
22292566
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Excitatory amplification through divergent-convergent circuits: the role of the midline thalamus in limbic seizures.

Sloan DM, Zhang D, Bertram EH 3rd.

Neurobiol Dis. 2011 Aug;43(2):435-45. doi: 10.1016/j.nbd.2011.04.017. Epub 2011 Apr 30.

PMID:
21554957
[PubMed - indexed for MEDLINE]
6.

Increased GABAergic inhibition in the midline thalamus affects signaling and seizure spread in the hippocampus-prefrontal cortex pathway.

Sloan DM, Zhang D, Bertram EH 3rd.

Epilepsia. 2011 Mar;52(3):523-30. doi: 10.1111/j.1528-1167.2010.02919.x. Epub 2011 Jan 4.

PMID:
21204829
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Temporal lobe epilepsy induces intrinsic alterations in Na channel gating in layer II medial entorhinal cortex neurons.

Hargus NJ, Merrick EC, Nigam A, Kalmar CL, Baheti AR, Bertram EH 3rd, Patel MK.

Neurobiol Dis. 2011 Feb;41(2):361-76. doi: 10.1016/j.nbd.2010.10.004. Epub 2010 Oct 11.

PMID:
20946956
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Changes in midline thalamic recruiting responses in the prefrontal cortex of the rat during the development of chronic limbic seizures.

Sloan DM, Bertram EH 3rd.

Epilepsia. 2009 Mar;50(3):556-65. doi: 10.1111/j.1528-1167.2008.01790.x. Epub 2008 Sep 17.

PMID:
18801032
[PubMed - indexed for MEDLINE]
9.

Hippocampal place cells in epileptic rats show alterations in activity: a possible clue to decreased memory performance.

Bertram EH 3rd.

Epilepsy Curr. 2004 Jul-Aug;4(4):156-7. No abstract available.

PMID:
16059484
[PubMed]
Free PMC Article
10.

Depression in intractable partial epilepsy varies by laterality of focus and surgery.

Quigg M, Broshek DK, Heidal-Schiltz S, Maedgen JW, Bertram EH 3rd.

Epilepsia. 2003 Mar;44(3):419-24.

PMID:
12614398
[PubMed - indexed for MEDLINE]
11.

Interictal and postictal alterations of pulsatile secretions of luteinizing hormone in temporal lobe epilepsy in men.

Quigg M, Kiely JM, Shneker B, Veldhuis JD, Bertram EH 3rd.

Ann Neurol. 2002 May;51(5):559-66.

PMID:
12112101
[PubMed - indexed for MEDLINE]
12.

Photothrombotic brain infarction results in seizure activity in aging Fischer 344 and Sprague Dawley rats.

Kelly KM, Kharlamov A, Hentosz TM, Kharlamova EA, Williamson JM, Bertram EH 3rd, Kapur J, Armstrong DM.

Epilepsy Res. 2001 Dec;47(3):189-203.

PMID:
11738927
[PubMed - indexed for MEDLINE]
13.

Effects of circadian regulation and rest-activity state on spontaneous seizures in a rat model of limbic epilepsy.

Quigg M, Clayburn H, Straume M, Menaker M, Bertram EH 3rd.

Epilepsia. 2000 May;41(5):502-9.

PMID:
10802754
[PubMed - indexed for MEDLINE]
14.

Hypothalamic neuronal loss and altered circadian rhythm of temperature in a rat model of mesial temporal lobe epilepsy.

Quigg M, Clayburn H, Straume M, Menaker M, Bertram EH 3rd.

Epilepsia. 1999 Dec;40(12):1688-96.

PMID:
10612331
[PubMed - indexed for MEDLINE]
15.

Hippocampal AMPA and NMDA mRNA levels and subunit immunoreactivity in human temporal lobe epilepsy patients and a rodent model of chronic mesial limbic epilepsy.

Mathern GW, Pretorius JK, Leite JP, Kornblum HI, Mendoza D, Lozada A, Bertram EH 3rd.

Epilepsy Res. 1998 Sep;32(1-2):154-71.

PMID:
9761317
[PubMed - indexed for MEDLINE]
16.

Ontogeny of altered synaptic function in a rat model of chronic temporal lobe epilepsy.

Mangan PS, Bertram EH 3rd.

Brain Res. 1998 Jul 20;799(2):183-96.

PMID:
9675275
[PubMed - indexed for MEDLINE]
17.

Responses of deep entorhinal cortex are epileptiform in an electrogenic rat model of chronic temporal lobe epilepsy.

Fountain NB, Bear J, Bertram EH 3rd, Lothman EW.

J Neurophysiol. 1998 Jul;80(1):230-40.

PMID:
9658044
[PubMed - indexed for MEDLINE]
Free Article
18.

Temporal distribution of partial seizures: comparison of an animal model with human partial epilepsy.

Quigg M, Straume M, Menaker M, Bertram EH 3rd.

Ann Neurol. 1998 Jun;43(6):748-55.

PMID:
9629844
[PubMed - indexed for MEDLINE]
19.

Shortened-duration GABA(A) receptor-mediated synaptic potentials underlie enhanced CA1 excitability in a chronic model of temporal lobe epilepsy.

Mangan PS, Bertram EH 3rd.

Neuroscience. 1997 Oct;80(4):1101-11.

PMID:
9284063
[PubMed - indexed for MEDLINE]
20.

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