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Page 1
Titanium particles activate toll-like receptor 4 independently of lipid rafts in RAW264.7 murine macrophages.
J Orthop Res. 2011 Feb;29(2):211-7. doi: 10.1002/jor.21199. Epub 2010 Aug 30.
J Orthop Res. 2011.
PMID: 20806319
Free PMC article.
Bacterial pathogen-associated molecular patterns stimulate biological activity of orthopaedic wear particles by activating cognate Toll-like receptors.
Greenfield EM, Beidelschies MA, Tatro JM, Goldberg VM, Hise AG.
Greenfield EM, et al. Among authors: beidelschies ma.
J Biol Chem. 2010 Oct 15;285(42):32378-84. doi: 10.1074/jbc.M110.136895. Epub 2010 Aug 19.
J Biol Chem. 2010.
PMID: 20729214
Free PMC article.
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Stimulation of macrophage TNFalpha production by orthopaedic wear particles requires activation of the ERK1/2/Egr-1 and NF-kappaB pathways but is independent of p38 and JNK.
Beidelschies MA, Huang H, McMullen MR, Smith MV, Islam AS, Goldberg VM, Chen X, Nagy LE, Greenfield EM.
Beidelschies MA, et al.
J Cell Physiol. 2008 Dec;217(3):652-66. doi: 10.1002/jcp.21539.
J Cell Physiol. 2008.
PMID: 18651635
Free PMC article.
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Inhibition of the PI3K-Akt signaling pathway reduces tumor necrosis factor-alpha production in response to titanium particles in vitro.
Smith MV, Lee MJ, Islam AS, Rohrer JL, Goldberg VM, Beidelschies MA, Greenfield EM.
Smith MV, et al. Among authors: beidelschies ma.
J Bone Joint Surg Am. 2007 May;89(5):1019-27. doi: 10.2106/JBJS.F.00615.
J Bone Joint Surg Am. 2007.
PMID: 17473139
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