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Results: 1 to 20 of 41

1.

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass.

Mercken EM, Mitchell SJ, Martin-Montalvo A, Minor RK, Almeida M, Gomes AP, Scheibye-Knudsen M, Palacios HH, Licata JJ, Zhang Y, Becker KG, Khraiwesh H, González-Reyes JA, Villalba JM, Baur JA, Elliott P, Westphal C, Vlasuk GP, Ellis JL, Sinclair DA, Bernier M, de Cabo R.

Aging Cell. 2014 Jun 16. doi: 10.1111/acel.12220. [Epub ahead of print]

PMID:
24931715
[PubMed - as supplied by publisher]
2.

Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates.

Mattison JA, Wang M, Bernier M, Zhang J, Park SS, Maudsley S, An SS, Santhanam L, Martin B, Faulkner S, Morrell C, Baur JA, Peshkin L, Sosnowska D, Csiszar A, Herbert RL, Tilmont EM, Ungvari Z, Pearson KJ, Lakatta EG, de Cabo R.

Cell Metab. 2014 Jul 1;20(1):183-90. doi: 10.1016/j.cmet.2014.04.018. Epub 2014 May 29.

PMID:
24882067
[PubMed - in process]
3.

Extended wakefulness: compromised metabolics in and degeneration of locus ceruleus neurons.

Zhang J, Zhu Y, Zhan G, Fenik P, Panossian L, Wang MM, Reid S, Lai D, Davis JG, Baur JA, Veasey S.

J Neurosci. 2014 Mar 19;34(12):4418-31. doi: 10.1523/JNEUROSCI.5025-12.2014.

PMID:
24647961
[PubMed - indexed for MEDLINE]
4.

Aging and sleep deprivation induce the unfolded protein response in the pancreas: implications for metabolism.

Naidoo N, Davis JG, Zhu J, Yabumoto M, Singletary K, Brown M, Galante R, Agarwal B, Baur JA.

Aging Cell. 2014 Feb;13(1):131-41. doi: 10.1111/acel.12158. Epub 2013 Nov 12.

PMID:
24102714
[PubMed - in process]
5.

Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet.

Jimenez-Gomez Y, Mattison JA, Pearson KJ, Martin-Montalvo A, Palacios HH, Sossong AM, Ward TM, Younts CM, Lewis K, Allard JS, Longo DL, Belman JP, Malagon MM, Navas P, Sanghvi M, Moaddel R, Tilmont EM, Herbert RL, Morrell CH, Egan JM, Baur JA, Ferrucci L, Bogan JS, Bernier M, de Cabo R.

Cell Metab. 2013 Oct 1;18(4):533-45. doi: 10.1016/j.cmet.2013.09.004.

PMID:
24093677
[PubMed - indexed for MEDLINE]
6.

mTOR: more targets of resveratrol?

Widlund AL, Baur JA, Vang O.

Expert Rev Mol Med. 2013 Sep 23;15:e10. doi: 10.1017/erm.2013.11. Review.

PMID:
24060150
[PubMed - indexed for MEDLINE]
7.

Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance.

Ye L, Widlund AL, Sims CA, Lamming DW, Guan Y, Davis JG, Sabatini DM, Harrison DE, Vang O, Baur JA.

Aging (Albany NY). 2013 Jul;5(7):539-50.

PMID:
23929887
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Primary respiratory chain disease causes tissue-specific dysregulation of the global transcriptome and nutrient-sensing signaling network.

Zhang Z, Tsukikawa M, Peng M, Polyak E, Nakamaru-Ogiso E, Ostrovsky J, McCormack S, Place E, Clarke C, Reiner G, McCormick E, Rappaport E, Haas R, Baur JA, Falk MJ.

PLoS One. 2013 Jul 24;8(7):e69282. doi: 10.1371/journal.pone.0069282. Print 2013.

PMID:
23894440
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.

Lamming DW, Ye L, Astle CM, Baur JA, Sabatini DM, Harrison DE.

Aging Cell. 2013 Aug;12(4):712-8. doi: 10.1111/acel.12097. Epub 2013 Jun 7.

PMID:
23648089
[PubMed - indexed for MEDLINE]
10.

Rapalogs and mTOR inhibitors as anti-aging therapeutics.

Lamming DW, Ye L, Sabatini DM, Baur JA.

J Clin Invest. 2013 Mar 1;123(3):980-9. doi: 10.1172/JCI64099. Epub 2013 Mar 1. Review.

PMID:
23454761
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Resveratrol for primary prevention of atherosclerosis: clinical trial evidence for improved gene expression in vascular endothelium.

Agarwal B, Campen MJ, Channell MM, Wherry SJ, Varamini B, Davis JG, Baur JA, Smoliga JM.

Int J Cardiol. 2013 Jun 5;166(1):246-8. doi: 10.1016/j.ijcard.2012.09.027. Epub 2012 Oct 23. No abstract available.

PMID:
23098852
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2.

Ye L, Varamini B, Lamming DW, Sabatini DM, Baur JA.

Front Genet. 2012 Sep 11;3:177. doi: 10.3389/fgene.2012.00177. eCollection 2012.

PMID:
22973301
[PubMed]
Free PMC Article
13.

Are sirtuins viable targets for improving healthspan and lifespan?

Baur JA, Ungvari Z, Minor RK, Le Couteur DG, de Cabo R.

Nat Rev Drug Discov. 2012 Jun 1;11(6):443-61. doi: 10.1038/nrd3738. Review.

PMID:
22653216
[PubMed - indexed for MEDLINE]
14.

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.

Price NL, Gomes AP, Ling AJ, Duarte FV, Martin-Montalvo A, North BJ, Agarwal B, Ye L, Ramadori G, Teodoro JS, Hubbard BP, Varela AT, Davis JG, Varamini B, Hafner A, Moaddel R, Rolo AP, Coppari R, Palmeira CM, de Cabo R, Baur JA, Sinclair DA.

Cell Metab. 2012 May 2;15(5):675-90. doi: 10.1016/j.cmet.2012.04.003.

PMID:
22560220
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.

Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, Baur JA.

Science. 2012 Mar 30;335(6076):1638-43. doi: 10.1126/science.1215135.

PMID:
22461615
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice.

Strong R, Miller RA, Astle CM, Baur JA, de Cabo R, Fernandez E, Guo W, Javors M, Kirkland JL, Nelson JF, Sinclair DA, Teter B, Williams D, Zaveri N, Nadon NL, Harrison DE.

J Gerontol A Biol Sci Med Sci. 2013 Jan;68(1):6-16. doi: 10.1093/gerona/gls070. Epub 2012 Mar 26.

PMID:
22451473
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

SRT1720 improves survival and healthspan of obese mice.

Minor RK, Baur JA, Gomes AP, Ward TM, Csiszar A, Mercken EM, Abdelmohsen K, Shin YK, Canto C, Scheibye-Knudsen M, Krawczyk M, Irusta PM, Martín-Montalvo A, Hubbard BP, Zhang Y, Lehrmann E, White AA, Price NL, Swindell WR, Pearson KJ, Becker KG, Bohr VA, Gorospe M, Egan JM, Talan MI, Auwerx J, Westphal CH, Ellis JL, Ungvari Z, Vlasuk GP, Elliott PJ, Sinclair DA, de Cabo R.

Sci Rep. 2011;1:70. doi: 10.1038/srep00070. Epub 2011 Aug 18. Erratum in: Sci Rep. 2013;3():1131.

PMID:
22355589
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Mitochondrial genome sequence analysis: a custom bioinformatics pipeline substantially improves Affymetrix MitoChip v2.0 call rate and accuracy.

Xie HM, Perin JC, Schurr TG, Dulik MC, Zhadanov SI, Baur JA, King MP, Place E, Clarke C, Grauer M, Schug J, Santani A, Albano A, Kim C, Procaccio V, Hakonarson H, Gai X, Falk MJ.

BMC Bioinformatics. 2011 Oct 19;12:402. doi: 10.1186/1471-2105-12-402.

PMID:
22011106
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Challenges of translating basic research into therapeutics: resveratrol as an example.

Smoliga JM, Vang O, Baur JA.

J Gerontol A Biol Sci Med Sci. 2012 Feb;67(2):158-67. doi: 10.1093/gerona/glr062. Epub 2011 Jul 11.

PMID:
21746739
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

What is new for an old molecule? Systematic review and recommendations on the use of resveratrol.

Vang O, Ahmad N, Baile CA, Baur JA, Brown K, Csiszar A, Das DK, Delmas D, Gottfried C, Lin HY, Ma QY, Mukhopadhyay P, Nalini N, Pezzuto JM, Richard T, Shukla Y, Surh YJ, Szekeres T, Szkudelski T, Walle T, Wu JM.

PLoS One. 2011;6(6):e19881. doi: 10.1371/journal.pone.0019881. Epub 2011 Jun 16. Review.

PMID:
21698226
[PubMed - indexed for MEDLINE]
Free PMC Article

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