Successful co-administration of a human rotavirus and oral poliovirus vaccines in Bangladeshi infants in a 2-dose schedule at 12 and 16 weeks of age

K Zaman; D A Sack; M Yunus; S E Arifeen; G Podder; T Azim; S Luby; R F Breiman; K Neuzil; S K Datta; A Delem; P V Suryakiran; H L Bock; Bangladeshi Rotavirus Vaccine study group

doi:10.1016/j.vaccine.2008.12.059

Successful co-administration of a human rotavirus and oral poliovirus vaccines in Bangladeshi infants in a 2-dose schedule at 12 and 16 weeks of age

Vaccine. 2009 Feb 25;27(9):1333-9. doi: 10.1016/j.vaccine.2008.12.059. Epub 2009 Jan 20.

Authors

K Zaman¹, D A Sack, M Yunus, S E Arifeen, G Podder, T Azim, S Luby, R F Breiman, K Neuzil, S K Datta, A Delem, P V Suryakiran, H L Bock; Bangladeshi Rotavirus Vaccine study group

Collaborators

Bangladeshi Rotavirus Vaccine study group:
A S G Faruque, E Huq, S Karim

Affiliation

¹ International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR, B), GPO Box-128, Mohakhali, Dhaka 1000, Bangladesh.

PMID: 19162114
DOI: 10.1016/j.vaccine.2008.12.059

Abstract

Co-administration of oral live-attenuated human rotavirus vaccine RIX4414 (Rotarix) and oral polio vaccine (OPV) was assessed. Healthy infants were randomised to receive 2-doses of either: RIX4414 or placebo co-administered with OPV (12 and 16 weeks of age); or RIX4414 or placebo given 15 days after OPV. After vaccination, 56.5-66.7% of RIX4414 and 18.6% of placebo recipients had seroconverted for rotavirus IgA. No significant differences between RIX4414 groups with or without OPV co-administration were observed. No statistically significant differences were observed between groups for polio seroprotection rates. RIX4414 vaccine was immunogenic when co-administered with OPV and did not interfere with OPV seroprotection rates.

Trial registration: ClinicalTrials.gov NCT00139334.

Publication types

Clinical Trial, Phase II
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Administration, Oral
Antibodies, Viral / blood
Antibody Formation
Bangladesh / epidemiology
Diarrhea / epidemiology
Diarrhea / immunology
Diarrhea / virology
Double-Blind Method
Drug Administration Schedule
Female
Gastroenteritis / epidemiology
Gastroenteritis / etiology
Gastroenteritis / immunology
Humans
Infant
Male
Poliomyelitis / immunology
Poliovirus Vaccines / administration & dosage
Poliovirus Vaccines / therapeutic use*
Rotavirus Infections / epidemiology
Rotavirus Infections / immunology*
Rotavirus Vaccines / administration & dosage
Rotavirus Vaccines / therapeutic use*

Substances

Antibodies, Viral
Poliovirus Vaccines
Rotavirus Vaccines

Associated data

ClinicalTrials.gov/NCT00139334