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Items: 1 to 20 of 76


Computationally driven antibody engineering enables simultaneous humanization and thermostabilization.

Choi Y, Ndong C, Griswold KE, Bailey-Kellogg C.

Protein Eng Des Sel. 2016 Jun 21. pii: gzw024. [Epub ahead of print]


Design and engineering of deimmunized biotherapeutics.

Griswold KE, Bailey-Kellogg C.

Curr Opin Struct Biol. 2016 Jun 17;39:79-88. doi: 10.1016/ [Epub ahead of print] Review.


Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition.

Vaccari M, Gordon SN, Fourati S, Schifanella L, Liyanage NP, Cameron M, Keele BF, Shen X, Tomaras GD, Billings E, Rao M, Chung AW, Dowell KG, Bailey-Kellogg C, Brown EP, Ackerman ME, Vargas-Inchaustegui DA, Whitney S, Doster MN, Binello N, Pegu P, Montefiori DC, Foulds K, Quinn DS, Donaldson M, Liang F, Loré K, Roederer M, Koup RA, McDermott A, Ma ZM, Miller CJ, Phan TB, Forthal DN, Blackburn M, Caccuri F, Bissa M, Ferrari G, Kalyanaraman V, Ferrari MG, Thompson D, Robert-Guroff M, Ratto-Kim S, Kim JH, Michael NL, Phogat S, Barnett SW, Tartaglia J, Venzon D, Stablein DM, Alter G, Sekaly RP, Franchini G.

Nat Med. 2016 May 30. doi: 10.1038/nm.4105. [Epub ahead of print]


Polyfunctional HIV-Specific Antibody Responses Are Associated with Spontaneous HIV Control.

Ackerman ME, Mikhailova A, Brown EP, Dowell KG, Walker BD, Bailey-Kellogg C, Suscovich TJ, Alter G.

PLoS Pathog. 2016 Jan 8;12(1):e1005315. doi: 10.1371/journal.ppat.1005315. eCollection 2016 Jan.


Hit-and-run, hit-and-stay, and commensal bacteria present different peptide content when viewed from the perspective of the T cell.

He L, De Groot AS, Bailey-Kellogg C.

Vaccine. 2015 Nov 27;33(48):6922-9. doi: 10.1016/j.vaccine.2015.08.099. Epub 2015 Oct 1.


Development and validation of an epitope prediction tool for swine (PigMatrix) based on the pocket profile method.

Gutiérrez AH, Martin WD, Bailey-Kellogg C, Terry F, Moise L, De Groot AS.

BMC Bioinformatics. 2015 Sep 15;16:290. doi: 10.1186/s12859-015-0724-8.


Antibody humanization by structure-based computational protein design.

Choi Y, Hua C, Sentman CL, Ackerman ME, Bailey-Kellogg C.

MAbs. 2015;7(6):1045-57. doi: 10.1080/19420862.2015.1076600. Epub 2015 Aug 7.


Structure-based redesign of lysostaphin yields potent antistaphylococcal enzymes that evade immune cell surveillance.

Blazanovic K, Zhao H, Choi Y, Li W, Salvat RS, Osipovitch DC, Fields J, Moise L, Berwin BL, Fiering SN, Bailey-Kellogg C, Griswold KE.

Mol Ther Methods Clin Dev. 2015 Jun 17;2:15021. doi: 10.1038/mtm.2015.21. eCollection 2015.


Depletion of T cell epitopes in lysostaphin mitigates anti-drug antibody response and enhances antibacterial efficacy in vivo.

Zhao H, Verma D, Li W, Choi Y, Ndong C, Fiering SN, Bailey-Kellogg C, Griswold KE.

Chem Biol. 2015 May 21;22(5):629-39. doi: 10.1016/j.chembiol.2015.04.017.


Learning sequence determinants of protein:protein interaction specificity with sparse graphical models.

Kamisetty H, Ghosh B, Langmead CJ, Bailey-Kellogg C.

J Comput Biol. 2015 Jun;22(6):474-86. doi: 10.1089/cmb.2014.0289. Epub 2015 May 14.


Machine learning methods enable predictive modeling of antibody feature:function relationships in RV144 vaccinees.

Choi I, Chung AW, Suscovich TJ, Rerks-Ngarm S, Pitisuttithum P, Nitayaphan S, Kaewkungwal J, O'Connell RJ, Francis D, Robb ML, Michael NL, Kim JH, Alter G, Ackerman ME, Bailey-Kellogg C.

PLoS Comput Biol. 2015 Apr 13;11(4):e1004185. doi: 10.1371/journal.pcbi.1004185. eCollection 2015 Apr.


Protein deimmunization via structure-based design enables efficient epitope deletion at high mutational loads.

Salvat RS, Choi Y, Bishop A, Bailey-Kellogg C, Griswold KE.

Biotechnol Bioeng. 2015 Jul;112(7):1306-18. doi: 10.1002/bit.25554. Epub 2015 Feb 23.


Structure-based design of combinatorial mutagenesis libraries.

Verma D, Grigoryan G, Bailey-Kellogg C.

Protein Sci. 2015 May;24(5):895-908. doi: 10.1002/pro.2642. Epub 2015 Mar 2.


Mapping the Pareto optimal design space for a functionally deimmunized biotherapeutic candidate.

Salvat RS, Parker AS, Choi Y, Bailey-Kellogg C, Griswold KE.

PLoS Comput Biol. 2015 Jan 8;11(1):e1003988. doi: 10.1371/journal.pcbi.1003988. eCollection 2015 Jan.


Immune camouflage: relevance to vaccines and human immunology.

De Groot AS, Moise L, Liu R, Gutierrez AH, Tassone R, Bailey-Kellogg C, Martin W.

Hum Vaccin Immunother. 2014;10(12):3570-5. doi: 10.4161/hv.36134.


Learning Sequence Determinants of Protein:protein Interaction Specificity with Sparse Graphical Models.

Kamisetty H, Ghosh B, Langmead CJ, Bailey-Kellogg C.

Res Comput Mol Biol. 2014;8394:129-143.


Smarter vaccine design will circumvent regulatory T cell-mediated evasion in chronic HIV and HCV infection.

Moise L, Terry F, Gutierrez AH, Tassone R, Losikoff P, Gregory SH, Bailey-Kellogg C, Martin WD, De Groot AS.

Front Microbiol. 2014 Oct 6;5:502. doi: 10.3389/fmicb.2014.00502. eCollection 2014.


Identification of antibody glycosylation structures that predict monoclonal antibody Fc-effector function.

Chung AW, Crispin M, Pritchard L, Robinson H, Gorny MK, Yu X, Bailey-Kellogg C, Ackerman ME, Scanlan C, Zolla-Pazner S, Alter G.

AIDS. 2014 Nov 13;28(17):2523-30. doi: 10.1097/QAD.0000000000000444.


HCV epitope, homologous to multiple human protein sequences, induces a regulatory T cell response in infected patients.

Losikoff PT, Mishra S, Terry F, Gutierrez A, Ardito MT, Fast L, Nevola M, Martin WD, Bailey-Kellogg C, De Groot AS, Gregory SH.

J Hepatol. 2015 Jan;62(1):48-55. doi: 10.1016/j.jhep.2014.08.026. Epub 2014 Aug 23.


Integrated assessment of predicted MHC binding and cross-conservation with self reveals patterns of viral camouflage.

He L, De Groot AS, Gutierrez AH, Martin WD, Moise L, Bailey-Kellogg C.

BMC Bioinformatics. 2014;15 Suppl 4:S1. doi: 10.1186/1471-2105-15-S4-S1. Epub 2014 Mar 19.

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