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Results: 1 to 20 of 109

1.

Indolinone based LRRK2 kinase inhibitors with a key hydrogen bond.

Göring S, Taymans JM, Baekelandt V, Schmidt B.

Bioorg Med Chem Lett. 2014 Oct 1;24(19):4630-7. doi: 10.1016/j.bmcl.2014.08.049. Epub 2014 Aug 29.

PMID:
25219901
[PubMed - in process]
2.

Regulation and targeting of enzymes mediating Parkinson's disease pathogenesis: focus on Parkinson's disease kinases, GTPases, and ATPases.

Taymans JM, Baekelandt V, Harvey K.

Front Mol Neurosci. 2014 Jul 29;7:71. doi: 10.3389/fnmol.2014.00071. eCollection 2014. No abstract available.

PMID:
25120428
[PubMed]
Free PMC Article
3.

Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice.

Oliveras-Salvá M, Macchi F, Coessens V, Deleersnijder A, Gérard M, Van der Perren A, Van den Haute C, Baekelandt V.

Neurobiol Aging. 2014 Nov;35(11):2625-36. doi: 10.1016/j.neurobiolaging.2014.04.032. Epub 2014 Jun 14.

PMID:
25037286
[PubMed - in process]
4.

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways.

Reyniers L, Del Giudice MG, Civiero L, Belluzzi E, Lobbestael E, Beilina A, Arrigoni G, Derua R, Waelkens E, Li Y, Crosio C, Iaccarino C, Cookson MR, Baekelandt V, Greggio E, Taymans JM.

J Neurochem. 2014 Jun 20. doi: 10.1111/jnc.12798. [Epub ahead of print]

PMID:
24947832
[PubMed - as supplied by publisher]
5.

In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2.

Vancraenenbroeck R, De Raeymaecker J, Lobbestael E, Gao F, De Maeyer M, Voet A, Baekelandt V, Taymans JM.

Front Mol Neurosci. 2014 Jun 3;7:51. doi: 10.3389/fnmol.2014.00051. eCollection 2014.

PMID:
24917786
[PubMed]
Free PMC Article
6.

Bioluminescence imaging of stroke-induced endogenous neural stem cell response.

Vandeputte C, Reumers V, Aelvoet SA, Thiry I, De Swaef S, Van den Haute C, Pascual-Brazo J, Farr TD, Vande Velde G, Hoehn M, Himmelreich U, Van Laere K, Debyser Z, Gijsbers R, Baekelandt V.

Neurobiol Dis. 2014 Sep;69:144-55. doi: 10.1016/j.nbd.2014.05.014. Epub 2014 May 27.

PMID:
24878507
[PubMed - in process]
7.

Viral Vector-Based Models of Parkinson's Disease.

Van der Perren A, Van den Haute C, Baekelandt V.

Curr Top Behav Neurosci. 2014 May 18. [Epub ahead of print]

PMID:
24839101
[PubMed - as supplied by publisher]
8.

Immunological ignorance allows long-term gene expression after perinatal recombinant adeno-associated virus-mediated gene transfer to murine airways.

Carlon MS, Vidović D, Dooley J, da Cunha MM, Maris M, Lampi Y, Toelen J, Van den Haute C, Baekelandt V, Deprest J, Verbeken E, Liston A, Gijsbers R, Debyser Z.

Hum Gene Ther. 2014 Jun;25(6):517-28. doi: 10.1089/hum.2013.196. Epub 2014 Mar 26.

PMID:
24548076
[PubMed - in process]
9.

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.

Beilina A, Rudenko IN, Kaganovich A, Civiero L, Chau H, Kalia SK, Kalia LV, Lobbestael E, Chia R, Ndukwe K, Ding J, Nalls MA; International Parkinson’s Disease Genomics Consortium; North American Brain Expression Consortium, Olszewski M, Hauser DN, Kumaran R, Lozano AM, Baekelandt V, Greene LE, Taymans JM, Greggio E, Cookson MR.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2626-31. doi: 10.1073/pnas.1318306111. Epub 2014 Feb 7.

PMID:
24510904
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

In vitro phosphorylation does not influence the aggregation kinetics of WT α-synuclein in contrast to its phosphorylation mutants.

Schreurs S, Gerard M, Derua R, Waelkens E, Taymans JM, Baekelandt V, Engelborghs Y.

Int J Mol Sci. 2014 Jan 15;15(1):1040-67. doi: 10.3390/ijms15011040.

PMID:
24434619
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis.

Remijsen Q, Goossens V, Grootjans S, Van den Haute C, Vanlangenakker N, Dondelinger Y, Roelandt R, Bruggeman I, Goncalves A, Bertrand MJ, Baekelandt V, Takahashi N, Berghe TV, Vandenabeele P.

Cell Death Dis. 2014 Jan 16;5:e1004. doi: 10.1038/cddis.2013.531.

PMID:
24434512
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Long-term overexpression of human wild-type and T240R mutant Parkin in rat substantia nigra induces progressive dopaminergic neurodegeneration.

Van Rompuy AS, Lobbestael E, Van der Perren A, Van den Haute C, Baekelandt V.

J Neuropathol Exp Neurol. 2014 Feb;73(2):159-74. doi: 10.1097/NEN.0000000000000039.

PMID:
24423640
[PubMed - indexed for MEDLINE]
13.

A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation.

Law BM, Spain VA, Leinster VH, Chia R, Beilina A, Cho HJ, Taymans JM, Urban MK, Sancho RM, Ramírez MB, Biskup S, Baekelandt V, Cai H, Cookson MR, Berwick DC, Harvey K.

J Biol Chem. 2014 Jan 10;289(2):895-908. doi: 10.1074/jbc.M113.507913. Epub 2013 Nov 25.

PMID:
24275654
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration.

Oliveras-Salvá M, Van der Perren A, Casadei N, Stroobants S, Nuber S, D'Hooge R, Van den Haute C, Baekelandt V.

Mol Neurodegener. 2013 Nov 25;8:44. doi: 10.1186/1750-1326-8-44.

PMID:
24267638
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Viral vectors expressing a single microRNA-based short-hairpin RNA result in potent gene silencing in vitro and in vivo.

Osório L, Gijsbers R, Oliveras-Salvá M, Michiels A, Debyser Z, Van den Haute C, Baekelandt V.

J Biotechnol. 2014 Jan;169:71-81. doi: 10.1016/j.jbiotec.2013.11.004. Epub 2013 Nov 16.

PMID:
24252659
[PubMed - indexed for MEDLINE]
16.

Neurogenesis as a new target for the development of antidepressant drugs.

Pascual-Brazo J, Baekelandt V, Encinas JM.

Curr Pharm Des. 2014;20(23):3763-75.

PMID:
24180394
[PubMed - in process]
17.

Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease.

Büttner S, Habernig L, Broeskamp F, Ruli D, Vögtle FN, Vlachos M, Macchi F, Küttner V, Carmona-Gutierrez D, Eisenberg T, Ring J, Markaki M, Taskin AA, Benke S, Ruckenstuhl C, Braun R, Van den Haute C, Bammens T, van der Perren A, Fröhlich KU, Winderickx J, Kroemer G, Baekelandt V, Tavernarakis N, Kovacs GG, Dengjel J, Meisinger C, Sigrist SJ, Madeo F.

EMBO J. 2013 Nov 27;32(23):3041-54. doi: 10.1038/emboj.2013.228. Epub 2013 Oct 15.

PMID:
24129513
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Metabolic labeling of leucine rich repeat kinases 1 and 2 with radioactive phosphate.

Taymans JM, Gao F, Baekelandt V.

J Vis Exp. 2013 Sep 18;(79):e50523. doi: 10.3791/50523.

PMID:
24084685
[PubMed - indexed for MEDLINE]
19.

Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle.

Lobbestael E, Zhao J, Rudenko IN, Beylina A, Gao F, Wetter J, Beullens M, Bollen M, Cookson MR, Baekelandt V, Nichols RJ, Taymans JM.

Biochem J. 2013 Nov 15;456(1):119-28. doi: 10.1042/BJ20121772.

PMID:
23937259
[PubMed - indexed for MEDLINE]
Free Article
20.

Local overexpression of interleukin-11 in the central nervous system limits demyelination and enhances remyelination.

Maheshwari A, Janssens K, Bogie J, Van Den Haute C, Struys T, Lambrichts I, Baekelandt V, Stinissen P, Hendriks JJ, Slaets H, Hellings N.

Mediators Inflamm. 2013;2013:685317. doi: 10.1155/2013/685317. Epub 2013 May 30.

PMID:
23818742
[PubMed - indexed for MEDLINE]
Free PMC Article

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