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Results: 1 to 20 of 113

1.

Longitudinal follow-up and characterization of a robust rat model for Parkinson's disease based on overexpression of alpha-synuclein with adeno-associated viral vectors.

Van der Perren A, Toelen J, Casteels C, Macchi F, Van Rompuy AS, Sarre S, Casadei N, Nuber S, Himmelreich U, Osorio Garcia MI, Michotte Y, D'Hooge R, Bormans G, Van Laere K, Gijsbers R, Van den Haute C, Debyser Z, Baekelandt V.

Neurobiol Aging. 2014 Dec 17. pii: S0197-4580(14)00786-6. doi: 10.1016/j.neurobiolaging.2014.11.015. [Epub ahead of print]

PMID:
25599874
[PubMed - as supplied by publisher]
2.

Leukemia inhibitory factor tips the immune balance towards regulatory T cells in multiple sclerosis.

Janssens K, Van den Haute C, Baekelandt V, Lucas S, van Horssen J, Somers V, Van Wijmeersch B, Stinissen P, Hendriks JJ, Slaets H, Hellings N.

Brain Behav Immun. 2014 Dec 13. pii: S0889-1591(14)00552-2. doi: 10.1016/j.bbi.2014.11.010. [Epub ahead of print]

PMID:
25514345
[PubMed - as supplied by publisher]
3.

Noninvasive bioluminescence imaging of α-synuclein oligomerization in mouse brain using split firefly luciferase reporters.

Aelvoet SA, Ibrahimi A, Macchi F, Gijsbers R, Van den Haute C, Debyser Z, Baekelandt V.

J Neurosci. 2014 Dec 3;34(49):16518-32. doi: 10.1523/JNEUROSCI.4933-13.2014.

PMID:
25471588
[PubMed - in process]
4.

Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of Parkinsonism.

Taymans JM, Baekelandt V.

Front Genet. 2014 Nov 7;5:382. doi: 10.3389/fgene.2014.00382. eCollection 2014. Review.

PMID:
25426138
[PubMed]
Free PMC Article
5.

Indolinone based LRRK2 kinase inhibitors with a key hydrogen bond.

Göring S, Taymans JM, Baekelandt V, Schmidt B.

Bioorg Med Chem Lett. 2014 Oct 1;24(19):4630-7. doi: 10.1016/j.bmcl.2014.08.049. Epub 2014 Aug 29.

PMID:
25219901
[PubMed - in process]
6.

Regulation and targeting of enzymes mediating Parkinson's disease pathogenesis: focus on Parkinson's disease kinases, GTPases, and ATPases.

Taymans JM, Baekelandt V, Harvey K.

Front Mol Neurosci. 2014 Jul 29;7:71. doi: 10.3389/fnmol.2014.00071. eCollection 2014. No abstract available.

PMID:
25120428
[PubMed]
Free PMC Article
7.

Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice.

Oliveras-Salvá M, Macchi F, Coessens V, Deleersnijder A, Gérard M, Van der Perren A, Van den Haute C, Baekelandt V.

Neurobiol Aging. 2014 Nov;35(11):2625-36. doi: 10.1016/j.neurobiolaging.2014.04.032. Epub 2014 Jun 14.

PMID:
25037286
[PubMed - in process]
8.

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways.

Reyniers L, Del Giudice MG, Civiero L, Belluzzi E, Lobbestael E, Beilina A, Arrigoni G, Derua R, Waelkens E, Li Y, Crosio C, Iaccarino C, Cookson MR, Baekelandt V, Greggio E, Taymans JM.

J Neurochem. 2014 Jun 20. doi: 10.1111/jnc.12798. [Epub ahead of print]

PMID:
24947832
[PubMed - as supplied by publisher]
9.

In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2.

Vancraenenbroeck R, De Raeymaecker J, Lobbestael E, Gao F, De Maeyer M, Voet A, Baekelandt V, Taymans JM.

Front Mol Neurosci. 2014 Jun 3;7:51. doi: 10.3389/fnmol.2014.00051. eCollection 2014.

PMID:
24917786
[PubMed]
Free PMC Article
10.

Bioluminescence imaging of stroke-induced endogenous neural stem cell response.

Vandeputte C, Reumers V, Aelvoet SA, Thiry I, De Swaef S, Van den Haute C, Pascual-Brazo J, Farr TD, Vande Velde G, Hoehn M, Himmelreich U, Van Laere K, Debyser Z, Gijsbers R, Baekelandt V.

Neurobiol Dis. 2014 Sep;69:144-55. doi: 10.1016/j.nbd.2014.05.014. Epub 2014 May 27.

PMID:
24878507
[PubMed - in process]
11.

Viral Vector-Based Models of Parkinson's Disease.

Van der Perren A, Van den Haute C, Baekelandt V.

Curr Top Behav Neurosci. 2014 May 18. [Epub ahead of print]

PMID:
24839101
[PubMed - as supplied by publisher]
12.

Immunological ignorance allows long-term gene expression after perinatal recombinant adeno-associated virus-mediated gene transfer to murine airways.

Carlon MS, Vidović D, Dooley J, da Cunha MM, Maris M, Lampi Y, Toelen J, Van den Haute C, Baekelandt V, Deprest J, Verbeken E, Liston A, Gijsbers R, Debyser Z.

Hum Gene Ther. 2014 Jun;25(6):517-28. doi: 10.1089/hum.2013.196. Epub 2014 Mar 26.

PMID:
24548076
[PubMed - in process]
13.

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.

Beilina A, Rudenko IN, Kaganovich A, Civiero L, Chau H, Kalia SK, Kalia LV, Lobbestael E, Chia R, Ndukwe K, Ding J, Nalls MA; International Parkinson’s Disease Genomics Consortium; North American Brain Expression Consortium, Olszewski M, Hauser DN, Kumaran R, Lozano AM, Baekelandt V, Greene LE, Taymans JM, Greggio E, Cookson MR.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2626-31. doi: 10.1073/pnas.1318306111. Epub 2014 Feb 7.

PMID:
24510904
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

In vitro phosphorylation does not influence the aggregation kinetics of WT α-synuclein in contrast to its phosphorylation mutants.

Schreurs S, Gerard M, Derua R, Waelkens E, Taymans JM, Baekelandt V, Engelborghs Y.

Int J Mol Sci. 2014 Jan 15;15(1):1040-67. doi: 10.3390/ijms15011040.

PMID:
24434619
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Depletion of RIPK3 or MLKL blocks TNF-driven necroptosis and switches towards a delayed RIPK1 kinase-dependent apoptosis.

Remijsen Q, Goossens V, Grootjans S, Van den Haute C, Vanlangenakker N, Dondelinger Y, Roelandt R, Bruggeman I, Goncalves A, Bertrand MJ, Baekelandt V, Takahashi N, Berghe TV, Vandenabeele P.

Cell Death Dis. 2014 Jan 16;5:e1004. doi: 10.1038/cddis.2013.531.

PMID:
24434512
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Long-term overexpression of human wild-type and T240R mutant Parkin in rat substantia nigra induces progressive dopaminergic neurodegeneration.

Van Rompuy AS, Lobbestael E, Van der Perren A, Van den Haute C, Baekelandt V.

J Neuropathol Exp Neurol. 2014 Feb;73(2):159-74. doi: 10.1097/NEN.0000000000000039.

PMID:
24423640
[PubMed - indexed for MEDLINE]
17.

A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation.

Law BM, Spain VA, Leinster VH, Chia R, Beilina A, Cho HJ, Taymans JM, Urban MK, Sancho RM, Blanca Ramírez M, Biskup S, Baekelandt V, Cai H, Cookson MR, Berwick DC, Harvey K.

J Biol Chem. 2014 Jan 10;289(2):895-908. doi: 10.1074/jbc.M113.507913. Epub 2013 Nov 25.

PMID:
24275654
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration.

Oliveras-Salvá M, Van der Perren A, Casadei N, Stroobants S, Nuber S, D'Hooge R, Van den Haute C, Baekelandt V.

Mol Neurodegener. 2013 Nov 25;8:44. doi: 10.1186/1750-1326-8-44.

PMID:
24267638
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Viral vectors expressing a single microRNA-based short-hairpin RNA result in potent gene silencing in vitro and in vivo.

Osório L, Gijsbers R, Oliveras-Salvá M, Michiels A, Debyser Z, Van den Haute C, Baekelandt V.

J Biotechnol. 2014 Jan;169:71-81. doi: 10.1016/j.jbiotec.2013.11.004. Epub 2013 Nov 16.

PMID:
24252659
[PubMed - indexed for MEDLINE]
20.

Neurogenesis as a new target for the development of antidepressant drugs.

Pascual-Brazo J, Baekelandt V, Encinas JM.

Curr Pharm Des. 2014;20(23):3763-75. Review.

PMID:
24180394
[PubMed - indexed for MEDLINE]

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