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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 32
1994 76
1995 138
1996 225
1997 286
1998 363
1999 390
2000 451
2001 466
2002 530
2003 502
2004 560
2005 579
2006 678
2007 687
2008 723
2009 808
2010 892
2011 914
2012 982
2013 999
2014 1056
2015 1150
2016 1188
2017 1219
2018 1263
2019 1371
2020 1572
2021 1596
2022 1545
2023 1393
2024 444

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22,484 results

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Page 1
BRCA1 as target for breast cancer prevention and therapy.
Romagnolo AP, Romagnolo DF, Selmin OI. Romagnolo AP, et al. Anticancer Agents Med Chem. 2015;15(1):4-14. doi: 10.2174/1871520614666141020153543. Anticancer Agents Med Chem. 2015. PMID: 25329591 Review.
Although BRCA1 acts as a tumor suppressor and is present in all cells, where it is essential for the maintenance of the genome integrity, it is still not clear why mutations in the BRCA1 gene predispose to breast and ovarian, but not to other types of cancer. ...The …
Although BRCA1 acts as a tumor suppressor and is present in all cells, where it is essential for the maintenance of the genome integr …
Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage.
Yoshida K, Miki Y. Yoshida K, et al. Cancer Sci. 2004 Nov;95(11):866-71. doi: 10.1111/j.1349-7006.2004.tb02195.x. Cancer Sci. 2004. PMID: 15546503 Free article. Review.
BRCA1 (BReast-CAncer susceptibility gene 1) and BRCA2 are tumor suppressor genes, the mutant phenotypes of which predispose to breast and ovarian cancers. Intensive research has shown that BRCA proteins are involved in a multitude of pivotal cellular processes. In p …
BRCA1 (BReast-CAncer susceptibility gene 1) and BRCA2 are tumor suppressor genes, the mutant phenotypes of which predispose to …
BRCA1 and p53: compensatory roles in DNA repair.
Hartman AR, Ford JM. Hartman AR, et al. J Mol Med (Berl). 2003 Nov;81(11):700-7. doi: 10.1007/s00109-003-0477-0. Epub 2003 Sep 9. J Mol Med (Berl). 2003. PMID: 13679996 Review.
BRCA1 plays a role in several DNA repair pathways including nucleotide excision repair (NER). Loss of the p53 tumor suppressor gene, a key regulator of NER, is an important and necessary event in the pathogenesis of BRCA1-mutated tumors. Here we discuss the role of …
BRCA1 plays a role in several DNA repair pathways including nucleotide excision repair (NER). Loss of the p53 tumor suppressor gene, …
BRCA1 and microRNAs: emerging networks and potential therapeutic targets.
Chang S, Sharan SK. Chang S, et al. Mol Cells. 2012 Nov;34(5):425-32. doi: 10.1007/s10059-012-0118-y. Epub 2012 Jul 24. Mol Cells. 2012. PMID: 22936386 Free PMC article. Review.
BRCA1 is a well-known tumor suppressor implicated in familial breast and ovarian cancer. Since its cloning in 1994, numerous studies have established BRCA1's role in diverse cellular and biochemical processes, such as DNA damage repair, cell cycle control, an …
BRCA1 is a well-known tumor suppressor implicated in familial breast and ovarian cancer. Since its cloning in 1994, numerous studies …
BRCA1 functions as a breast stem cell regulator.
Foulkes WD. Foulkes WD. J Med Genet. 2004 Jan;41(1):1-5. doi: 10.1136/jmg.2003.013805. J Med Genet. 2004. PMID: 14729816 Free PMC article. Review.
Others have indicated a CD44 positive, CD24 negative phenotype for breast cancer stem cells. In this paper, I argue that the biology of human BRCA1 and its rodent homologues and the clinicopathological features of breast cancer related to BRCA1 support the notion th …
Others have indicated a CD44 positive, CD24 negative phenotype for breast cancer stem cells. In this paper, I argue that the biology of huma …
BRCA1 in cancer, cell cycle and genomic stability.
Jhanwar-Uniyal M. Jhanwar-Uniyal M. Front Biosci. 2003 Sep 1;8:s1107-17. doi: 10.2741/1131. Front Biosci. 2003. PMID: 12957814 Review.
The functional inactivation of both copies of this gene in sporadic tumor cells does not follow the traditional mode: the loss of function in BRCA1 is not accompanied by underlying mutation of the gene in tumor cells with loss of heterozygosity for the BRCA1 gene. . …
The functional inactivation of both copies of this gene in sporadic tumor cells does not follow the traditional mode: the loss of function i …
BRCA1: a locus-specific "liaison" in gene expression and genetic integrity.
Aiyar S, Sun JL, Li R. Aiyar S, et al. J Cell Biochem. 2005 Apr 15;94(6):1103-11. doi: 10.1002/jcb.20386. J Cell Biochem. 2005. PMID: 15723343 Review.
Mutations in BRCA1 predominantly lead to elevated risks of breast and ovarian cancers. ...Such a coordinating role of BRCA1 in gene expression may ensure the appropriate quantity and quality of the mature transcripts for certain breast and ovarian cancer-related …
Mutations in BRCA1 predominantly lead to elevated risks of breast and ovarian cancers. ...Such a coordinating role of BRCA1 in …
Which Genes for Hereditary Breast Cancer?
Narod SA. Narod SA. N Engl J Med. 2021 Feb 4;384(5):471-473. doi: 10.1056/NEJMe2035083. Epub 2021 Jan 20. N Engl J Med. 2021. PMID: 33471975 No abstract available.
BRCA1 polymorphisms.
Campbell IG, Schroff R, Englefield P, Eccles DM. Campbell IG, et al. Br J Cancer. 1997;75(12):1854-5. doi: 10.1038/bjc.1997.318. Br J Cancer. 1997. PMID: 9192995 Free PMC article. No abstract available.
BRCA1 mutations.
DiCioccio RA, Werness BA, Piver MS. DiCioccio RA, et al. Genes Chromosomes Cancer. 2003 Jun;37(2):222. doi: 10.1002/gcc.10208. Genes Chromosomes Cancer. 2003. PMID: 12696073 No abstract available.
22,484 results
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