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Results: 18


Impaired in vivo mitochondrial Krebs cycle activity after myocardial infarction assessed using hyperpolarized magnetic resonance spectroscopy.

Dodd MS, Atherton HJ, Carr CA, Stuckey DJ, West JA, Griffin JL, Radda GK, Clarke K, Heather LC, Tyler DJ.

Circ Cardiovasc Imaging. 2014 Nov;7(6):895-904. doi: 10.1161/CIRCIMAGING.114.001857. Epub 2014 Sep 8.


Differential translocation of the fatty acid transporter, FAT/CD36, and the glucose transporter, GLUT4, coordinates changes in cardiac substrate metabolism during ischemia and reperfusion.

Heather LC, Pates KM, Atherton HJ, Cole MA, Ball DR, Evans RD, Glatz JF, Luiken JJ, Griffin JL, Clarke K.

Circ Heart Fail. 2013 Sep 1;6(5):1058-66. doi: 10.1161/CIRCHEARTFAILURE.112.000342. Epub 2013 Aug 12.


Adaptive changes of the Insig1/SREBP1/SCD1 set point help adipose tissue to cope with increased storage demands of obesity.

Carobbio S, Hagen RM, Lelliott CJ, Slawik M, Medina-Gomez G, Tan CY, Sicard A, Atherton HJ, Barbarroja N, Bjursell M, Bohlooly-Y M, Virtue S, Tuthill A, Lefai E, Laville M, Wu T, Considine RV, Vidal H, Langin D, Oresic M, Tinahones FJ, Fernandez-Real JM, Griffin JL, Sethi JK, López M, Vidal-Puig A.

Diabetes. 2013 Nov;62(11):3697-708. doi: 10.2337/db12-1748. Epub 2013 Aug 6.


In vivo alterations in cardiac metabolism and function in the spontaneously hypertensive rat heart.

Dodd MS, Ball DR, Schroeder MA, Le Page LM, Atherton HJ, Heather LC, Seymour AM, Ashrafian H, Watkins H, Clarke K, Tyler DJ.

Cardiovasc Res. 2012 Jul 1;95(1):69-76. doi: 10.1093/cvr/cvs164. Epub 2012 May 16.


The cycling of acetyl-coenzyme A through acetylcarnitine buffers cardiac substrate supply: a hyperpolarized 13C magnetic resonance study.

Schroeder MA, Atherton HJ, Dodd MS, Lee P, Cochlin LE, Radda GK, Clarke K, Tyler DJ.

Circ Cardiovasc Imaging. 2012 Mar;5(2):201-9. doi: 10.1161/CIRCIMAGING.111.969451. Epub 2012 Jan 11.


A Metadata description of the data in "A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human.".

Griffin JL, Atherton HJ, Steinbeck C, Salek RM.

BMC Res Notes. 2011 Jul 29;4:272. doi: 10.1186/1756-0500-4-272.


Role of pyruvate dehydrogenase inhibition in the development of hypertrophy in the hyperthyroid rat heart: a combined magnetic resonance imaging and hyperpolarized magnetic resonance spectroscopy study.

Atherton HJ, Dodd MS, Heather LC, Schroeder MA, Griffin JL, Radda GK, Clarke K, Tyler DJ.

Circulation. 2011 Jun 7;123(22):2552-61. doi: 10.1161/CIRCULATIONAHA.110.011387. Epub 2011 May 23.


Determining the in vivo regulation of cardiac pyruvate dehydrogenase based on label flux from hyperpolarised [1-13C]pyruvate.

Schroeder MA, Atherton HJ, Heather LC, Griffin JL, Clarke K, Radda GK, Tyler DJ.

NMR Biomed. 2011 Oct;24(8):980-7. doi: 10.1002/nbm.1668. Epub 2011 Mar 8.


Validation of the in vivo assessment of pyruvate dehydrogenase activity using hyperpolarised 13C MRS.

Atherton HJ, Schroeder MA, Dodd MS, Heather LC, Carter EE, Cochlin LE, Nagel S, Sibson NR, Radda GK, Clarke K, Tyler DJ.

NMR Biomed. 2011 Feb;24(2):201-8. doi: 10.1002/nbm.1573. Epub 2010 Aug 26.


Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy.

Dunn WB, Broadhurst DI, Atherton HJ, Goodacre R, Griffin JL.

Chem Soc Rev. 2011 Jan;40(1):387-426. doi: 10.1039/b906712b. Epub 2010 Aug 17. Review.


Measuring intracellular pH in the heart using hyperpolarized carbon dioxide and bicarbonate: a 13C and 31P magnetic resonance spectroscopy study.

Schroeder MA, Swietach P, Atherton HJ, Gallagher FA, Lee P, Radda GK, Clarke K, Tyler DJ.

Cardiovasc Res. 2010 Apr 1;86(1):82-91. doi: 10.1093/cvr/cvp396. Epub 2009 Dec 15.


Adenosine monophosphate-activated protein kinase activation, substrate transporter translocation, and metabolism in the contracting hyperthyroid rat heart.

Heather LC, Cole MA, Atherton HJ, Coumans WA, Evans RD, Tyler DJ, Glatz JF, Luiken JJ, Clarke K.

Endocrinology. 2010 Jan;151(1):422-31. doi: 10.1210/en.2009-0593. Epub 2009 Nov 25.


Metabolomics of the interaction between PPAR-alpha and age in the PPAR-alpha-null mouse.

Atherton HJ, Gulston MK, Bailey NJ, Cheng KK, Zhang W, Clarke K, Griffin JL.

Mol Syst Biol. 2009;5:259. doi: 10.1038/msb.2009.18. Epub 2009 Apr 7.


Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy.

Schroeder MA, Atherton HJ, Ball DR, Cole MA, Heather LC, Griffin JL, Clarke K, Radda GK, Tyler DJ.

FASEB J. 2009 Aug;23(8):2529-38. doi: 10.1096/fj.09-129171. Epub 2009 Mar 27.


The effect of hyperpolarized tracer concentration on myocardial uptake and metabolism.

Schroeder MA, Atherton HJ, Cochlin LE, Clarke K, Radda GK, Tyler DJ.

Magn Reson Med. 2009 May;61(5):1007-14. doi: 10.1002/mrm.21934.


A comparative metabolomic study of NHR-49 in Caenorhabditis elegans and PPAR-alpha in the mouse.

Atherton HJ, Jones OA, Malik S, Miska EA, Griffin JL.

FEBS Lett. 2008 May 28;582(12):1661-6. doi: 10.1016/j.febslet.2008.04.020. Epub 2008 Apr 22.


A combined metabolomic and proteomic investigation of the effects of a failure to express dystrophin in the mouse heart.

Gulston MK, Rubtsov DV, Atherton HJ, Clarke K, Davies KE, Lilley KS, Griffin JL.

J Proteome Res. 2008 May;7(5):2069-77. doi: 10.1021/pr800070p. Epub 2008 Apr 3.


A combined 1H-NMR spectroscopy- and mass spectrometry-based metabolomic study of the PPAR-alpha null mutant mouse defines profound systemic changes in metabolism linked to the metabolic syndrome.

Atherton HJ, Bailey NJ, Zhang W, Taylor J, Major H, Shockcor J, Clarke K, Griffin JL.

Physiol Genomics. 2006 Oct 11;27(2):178-86. Epub 2006 Jul 25.

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