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Results: 1 to 20 of 26

1.

The human early-life exposome (HELIX): project rationale and design.

Vrijheid M, Slama R, Robinson O, Chatzi L, Coen M, van den Hazel P, Thomsen C, Wright J, Athersuch TJ, Avellana N, Basagaña X, Brochot C, Bucchini L, Bustamante M, Carracedo A, Casas M, Estivill X, Fairley L, van Gent D, Gonzalez JR, Granum B, Gražulevičienė R, Gutzkow KB, Julvez J, Keun HC, Kogevinas M, McEachan RR, Meltzer HM, Sabidó E, Schwarze PE, Siroux V, Sunyer J, Want EJ, Zeman F, Nieuwenhuijsen MJ.

Environ Health Perspect. 2014 Jun;122(6):535-44. doi: 10.1289/ehp.1307204. Epub 2014 Mar 6.

PMID:
24610234
[PubMed - in process]
Free PMC Article
2.

Evaluation of 1H NMR metabolic profiling using biofluid mixture design.

Athersuch TJ, Malik S, Weljie A, Newton J, Keun HC.

Anal Chem. 2013 Jul 16;85(14):6674-81. doi: 10.1021/ac400449f. Epub 2013 Jun 26.

PMID:
23730812
[PubMed - indexed for MEDLINE]
3.

A combination of transcriptomics and metabolomics uncovers enhanced bile acid biosynthesis in HepG2 cells expressing CCAAT/enhancer-binding protein β (C/EBPβ), hepatocyte nuclear factor 4α (HNF4α), and constitutive androstane receptor (CAR).

Blazquez M, Carretero A, Ellis JK, Athersuch TJ, Cavill R, Ebbels TM, Keun HC, Castell JV, Lahoz A, Bort R.

J Proteome Res. 2013 Jun 7;12(6):2732-41. doi: 10.1021/pr400085n. Epub 2013 May 15.

PMID:
23641669
[PubMed - indexed for MEDLINE]
4.

Delineation of the key aspects in the regulation of epithelial monolayer formation.

Aschauer L, Gruber LN, Pfaller W, Limonciel A, Athersuch TJ, Cavill R, Khan A, Gstraunthaler G, Grillari J, Grillari R, Hewitt P, Leonard MO, Wilmes A, Jennings P.

Mol Cell Biol. 2013 Jul;33(13):2535-50. doi: 10.1128/MCB.01435-12. Epub 2013 Apr 22.

PMID:
23608536
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Advancing the application of omics-based biomarkers in environmental epidemiology.

Vineis P, van Veldhoven K, Chadeau-Hyam M, Athersuch TJ.

Environ Mol Mutagen. 2013 Aug;54(7):461-7. doi: 10.1002/em.21764. Epub 2013 Mar 21.

PMID:
23519765
[PubMed - indexed for MEDLINE]
6.

Performance in omics analyses of blood samples in long-term storage: opportunities for the exploitation of existing biobanks in environmental health research.

Hebels DG, Georgiadis P, Keun HC, Athersuch TJ, Vineis P, Vermeulen R, Portengen L, Bergdahl IA, Hallmans G, Palli D, Bendinelli B, Krogh V, Tumino R, Sacerdote C, Panico S, Kleinjans JC, de Kok TM, Smith MT, Kyrtopoulos SA; EnviroGenomarkers Project Consortium.

Environ Health Perspect. 2013 Apr;121(4):480-7. doi: 10.1289/ehp.1205657. Epub 2013 Feb 4.

PMID:
23384616
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Development of quantitative structure-metabolism (QSMR) relationships for substituted anilines based on computational chemistry.

Athersuch TJ, Wilson ID, Keun HC, Lindon JC.

Xenobiotica. 2013 Sep;43(9):792-802. doi: 10.3109/00498254.2013.767953. Epub 2013 Feb 6.

PMID:
23384072
[PubMed - indexed for MEDLINE]
8.

The role of metabolomics in characterizing the human exposome.

Athersuch TJ.

Bioanalysis. 2012 Sep;4(18):2207-12. doi: 10.4155/bio.12.211. No abstract available.

PMID:
23046263
[PubMed - indexed for MEDLINE]
9.

Metabolic profiling detects early effects of environmental and lifestyle exposure to cadmium in a human population.

Ellis JK, Athersuch TJ, Thomas LD, Teichert F, Pérez-Trujillo M, Svendsen C, Spurgeon DJ, Singh R, Järup L, Bundy JG, Keun HC.

BMC Med. 2012 Jun 19;10:61. doi: 10.1186/1741-7015-10-61.

PMID:
22713677
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Chiral metabonomics: 1H NMR-based enantiospecific differentiation of metabolites in human urine via direct cosolvation with β-cyclodextrin.

Pérez-Trujillo M, Lindon JC, Parella T, Keun HC, Nicholson JK, Athersuch TJ.

Anal Chem. 2012 Mar 20;84(6):2868-74. doi: 10.1021/ac203291d. Epub 2012 Feb 29.

PMID:
22320312
[PubMed - indexed for MEDLINE]
11.

A metabolic phenotyping approach to understanding relationships between metabolic syndrome and breast tumour responses to chemotherapy.

Stebbing J, Sharma A, North B, Athersuch TJ, Zebrowski A, Pchejetski D, Coombes RC, Nicholson JK, Keun HC.

Ann Oncol. 2012 Apr;23(4):860-6. doi: 10.1093/annonc/mdr347. Epub 2011 Aug 4.

PMID:
21821546
[PubMed - indexed for MEDLINE]
Free Article
12.

The intake of grain fibers modulates cytokine levels in blood.

Chuang SC, Vermeulen R, Sharabiani MT, Sacerdote C, Fatemeh SH, Berrino F, Krogh V, Palli D, Panico S, Tumino R, Athersuch TJ, Vineis P.

Biomarkers. 2011 Sep;16(6):504-10. doi: 10.3109/1354750X.2011.599042. Epub 2011 Aug 3.

PMID:
21812595
[PubMed - indexed for MEDLINE]
13.

Consensus-phenotype integration of transcriptomic and metabolomic data implies a role for metabolism in the chemosensitivity of tumour cells.

Cavill R, Kamburov A, Ellis JK, Athersuch TJ, Blagrove MS, Herwig R, Ebbels TM, Keun HC.

PLoS Comput Biol. 2011 Mar;7(3):e1001113. doi: 10.1371/journal.pcbi.1001113. Epub 2011 Mar 31.

PMID:
21483477
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Nuclear magnetic resonance (NMR)-based metabolomics.

Keun HC, Athersuch TJ.

Methods Mol Biol. 2011;708:321-34. doi: 10.1007/978-1-61737-985-7_19.

PMID:
21207299
[PubMed - indexed for MEDLINE]
15.

Meeting-in-the-middle using metabolic profiling - a strategy for the identification of intermediate biomarkers in cohort studies.

Chadeau-Hyam M, Athersuch TJ, Keun HC, De Iorio M, Ebbels TM, Jenab M, Sacerdote C, Bruce SJ, Holmes E, Vineis P.

Biomarkers. 2011 Feb;16(1):83-8. doi: 10.3109/1354750X.2010.533285. Epub 2010 Nov 29.

PMID:
21114379
[PubMed - indexed for MEDLINE]
16.

Metabolic response to low-level toxicant exposure in a novel renal tubule epithelial cell system.

Ellis JK, Athersuch TJ, Cavill R, Radford R, Slattery C, Jennings P, McMorrow T, Ryan MP, Ebbels TM, Keun HC.

Mol Biosyst. 2011 Jan;7(1):247-57. doi: 10.1039/c0mb00146e. Epub 2010 Nov 19.

PMID:
21103459
[PubMed - indexed for MEDLINE]
17.

UPLC-MS, HPLC-radiometric, and NMR-spectroscopic studies on the metabolic fate of 3-fluoro-[U-14C]-aniline in the bile-cannulated rat.

Athersuch TJ, Castro-Perez J, Rodgers C, Nicholson JK, Wilson ID.

Xenobiotica. 2010 Jul;40(7):510-23. doi: 10.3109/00498254.2010.483294.

PMID:
20443683
[PubMed - indexed for MEDLINE]
18.

Effect of the histone deacetylase inhibitor trichostatin a on the metabolome of cultured primary hepatocytes.

Ellis JK, Chan PH, Doktorova T, Athersuch TJ, Cavill R, Vanhaecke T, Rogiers V, Vinken M, Nicholson JK, M D Ebbels T, Keun HC.

J Proteome Res. 2010 Jan;9(1):413-9. doi: 10.1021/pr9007656.

PMID:
19894772
[PubMed - indexed for MEDLINE]
19.

Pivotal role for two electron reduction in 2,3-dimethoxy-1,4-naphthoquinone and 2-methyl-1,4-naphthoquinone metabolism and kinetics in vivo that prevents liver redox stress.

Parry JD, Pointon AV, Lutz U, Teichert F, Charlwood JK, Chan PH, Athersuch TJ, Taylor EL, Singh R, Luo J, Phillips KM, Vetillard A, Lyon JJ, Keun HC, Lutz WK, Gant TW.

Chem Res Toxicol. 2009 Apr;22(4):717-25. doi: 10.1021/tx800472z.

PMID:
19338340
[PubMed - indexed for MEDLINE]
20.

Robust algorithms for automated chemical shift calibration of 1D 1H NMR spectra of blood serum.

Pearce JT, Athersuch TJ, Ebbels TM, Lindon JC, Nicholson JK, Keun HC.

Anal Chem. 2008 Sep 15;80(18):7158-62. doi: 10.1021/ac8011494. Epub 2008 Aug 15.

PMID:
18702533
[PubMed - indexed for MEDLINE]

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