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Year Number of Results
1985 1
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1997 6
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1,246 results

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Plasmodium falciparum resistance to artemisinin-based combination therapies.
Ward KE, Fidock DA, Bridgford JL. Ward KE, et al. Curr Opin Microbiol. 2022 Oct;69:102193. doi: 10.1016/j.mib.2022.102193. Epub 2022 Aug 22. Curr Opin Microbiol. 2022. PMID: 36007459 Free PMC article. Review.
Here, we review recent advances in elucidating the mechanistic basis of artemisinin resistance, driven primarily by point mutations in P. falciparum Kelch13, a key regulator of hemoglobin endocytosis and parasite response to artemisinin-induced stress. ...
Here, we review recent advances in elucidating the mechanistic basis of artemisinin resistance, driven primarily by point mutations i …
The treatment of malaria.
White NJ. White NJ. N Engl J Med. 1996 Sep 12;335(11):800-6. doi: 10.1056/NEJM199609123351107. N Engl J Med. 1996. PMID: 8703186 Review.
Mefloquine, halofantrine, or quinine with tetracycline can be used to treat multidrug-resistant P. falciparum. Derivatives of artemisinin obtained from qinghao or sweet wormwood developed as pharmaceuticals in China are the most rapidly acting of all antimalarial drugs. .. …
Mefloquine, halofantrine, or quinine with tetracycline can be used to treat multidrug-resistant P. falciparum. Derivatives of artemisinin …
Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria.
Wicht KJ, Mok S, Fidock DA. Wicht KJ, et al. Annu Rev Microbiol. 2020 Sep 8;74:431-454. doi: 10.1146/annurev-micro-020518-115546. Annu Rev Microbiol. 2020. PMID: 32905757 Free PMC article. Review.
Understanding and controlling the spread of antimalarial resistance, particularly to artemisinin and its partner drugs, is a top priority. Plasmodium falciparum parasites resistant to chloroquine, amodiaquine, or piperaquine harbor mutations in the P. falciparum chloroquin …
Understanding and controlling the spread of antimalarial resistance, particularly to artemisinin and its partner drugs, is a top prio …
The immunosuppressive activity of artemisinin-type drugs towards inflammatory and autoimmune diseases.
Efferth T, Oesch F. Efferth T, et al. Med Res Rev. 2021 Nov;41(6):3023-3061. doi: 10.1002/med.21842. Epub 2021 Jul 21. Med Res Rev. 2021. PMID: 34288018 Review.
The sesquiterpene lactone artemisinin from Artemisia annua L. is well established for malaria therapy, but its bioactivity spectrum is much broader. In this review, we give a comprehensive and timely overview of the literature regarding the immunosuppressive activity of …
The sesquiterpene lactone artemisinin from Artemisia annua L. is well established for malaria therapy, but its bioactivity spectrum i …
A molecular marker of artemisinin-resistant Plasmodium falciparum malaria.
Ariey F, Witkowski B, Amaratunga C, Beghain J, Langlois AC, Khim N, Kim S, Duru V, Bouchier C, Ma L, Lim P, Leang R, Duong S, Sreng S, Suon S, Chuor CM, Bout DM, Ménard S, Rogers WO, Genton B, Fandeur T, Miotto O, Ringwald P, Le Bras J, Berry A, Barale JC, Fairhurst RM, Benoit-Vical F, Mercereau-Puijalon O, Ménard D. Ariey F, et al. Nature. 2014 Jan 2;505(7481):50-5. doi: 10.1038/nature12876. Epub 2013 Dec 18. Nature. 2014. PMID: 24352242 Free PMC article.
Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens malaria control and elimination activities worldwide. To monitor the spread of artemisinin resistance, a molecular marker is urgently needed. Here, using whole-genome sequencing …
Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens malaria control and elimination activities wo …
Artemisinin compounds sensitize cancer cells to ferroptosis by regulating iron homeostasis.
Chen GQ, Benthani FA, Wu J, Liang D, Bian ZX, Jiang X. Chen GQ, et al. Cell Death Differ. 2020 Jan;27(1):242-254. doi: 10.1038/s41418-019-0352-3. Epub 2019 May 21. Cell Death Differ. 2020. PMID: 31114026 Free PMC article.
The antimalarial drug artemisinin and its derivatives have been explored as potential anticancer agents, but their underlying mechanisms are controversial. In this study, we found that artemisinin compounds can sensitize cancer cells to ferroptosis, a new form of pr …
The antimalarial drug artemisinin and its derivatives have been explored as potential anticancer agents, but their underlying mechani …
CHSY1 promotes CD8+ T cell exhaustion through activation of succinate metabolism pathway leading to colorectal cancer liver metastasis based on CRISPR/Cas9 screening.
Sun G, Zhao S, Fan Z, Wang Y, Liu H, Cao H, Sun G, Huang T, Cai H, Pan H, Rong D, Gao Y, Tang W. Sun G, et al. J Exp Clin Cancer Res. 2023 Sep 25;42(1):248. doi: 10.1186/s13046-023-02803-0. J Exp Clin Cancer Res. 2023. PMID: 37749638 Free PMC article.
PLGA-loaded Artemisinin and ICG probe reduced liver metastasis and increased the efficiency of anti-PD1 treatment in CRC. ...The combination of CHSY1 knockdown and anti-PD1 contributes to synergistic resistance to CRC liver metastasis. Artemisinin significantly inhi …
PLGA-loaded Artemisinin and ICG probe reduced liver metastasis and increased the efficiency of anti-PD1 treatment in CRC. ...The comb …
Inhibition of Cysteine Proteases via Thiol-Michael Addition Explains the Anti-SARS-CoV-2 and Bioactive Properties of Arteannuin B.
Varela K, Arman HD, Berger MS, Sponsel VM, Lin CA, Yoshimoto FK. Varela K, et al. J Nat Prod. 2023 Jul 28;86(7):1654-1666. doi: 10.1021/acs.jnatprod.2c01146. Epub 2023 Jul 17. J Nat Prod. 2023. PMID: 37458412
This methyl ester was thought to be formed from the reaction between arteannuin B and the extracting solvent, which was supported by the fact that arteannuin B underwent 1,2-addition when it was dissolved in deuteromethanol. In contrast, in the presence of N- …
This methyl ester was thought to be formed from the reaction between arteannuin B and the extracting solvent, which was supported by …
Bangladesh in the era of malaria elimination.
Haldar K, Alam MS, Koepfli C, Lobo NF, Phru CS, Islam MN, Faiz A, Khan WA, Haque R. Haldar K, et al. Trends Parasitol. 2023 Sep;39(9):760-773. doi: 10.1016/j.pt.2023.06.009. Epub 2023 Jul 25. Trends Parasitol. 2023. PMID: 37500334 Review.
These districts border Myanmar which harbors Plasmodium falciparum malaria parasites resistant to artemisinins, key drugs used in artemisinin-based combination therapies (ACTs) that have been vital for control programs. Challenges in monitoring emergence of artemisinin …
These districts border Myanmar which harbors Plasmodium falciparum malaria parasites resistant to artemisinins, key drugs used in artemis …
Genomic Approaches to Drug Resistance in Malaria.
Rocamora F, Winzeler EA. Rocamora F, et al. Annu Rev Microbiol. 2020 Sep 8;74:761-786. doi: 10.1146/annurev-micro-012220-064343. Annu Rev Microbiol. 2020. PMID: 32905749 Review.
Although the last two decades have seen a substantial decline in malaria incidence and mortality due to the use of insecticide-treated bed nets and artemisinin combination therapy, the threat of drug resistance is a constant obstacle to sustainable malaria control. ...
Although the last two decades have seen a substantial decline in malaria incidence and mortality due to the use of insecticide-treated bed n …
1,246 results