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Results: 1 to 20 of 57

1.

Retrospective study of a TTR FAP cohort to modify NIS+7 for therapeutic trials.

Suanprasert N, Berk JL, Benson MD, Dyck PJ, Klein CJ, Gollob JA, Bettencourt BR, Karsten V, Dyck PJ.

J Neurol Sci. 2014 Jun 27. pii: S0022-510X(14)00411-0. doi: 10.1016/j.jns.2014.06.041. [Epub ahead of print]

PMID:
25012480
[PubMed - as supplied by publisher]
2.

The roles of individual Mammalian argonautes in RNA interference in vivo.

Ruda VM, Chandwani R, Sehgal A, Bogorad RL, Akinc A, Charisse K, Tarakhovsky A, Novobrantseva TI, Koteliansky V.

PLoS One. 2014 Jul 3;9(7):e101749. doi: 10.1371/journal.pone.0101749. eCollection 2014.

PMID:
24992693
[PubMed - in process]
Free PMC Article
3.

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity.

Whitehead KA, Dorkin JR, Vegas AJ, Chang PH, Veiseh O, Matthews J, Fenton OS, Zhang Y, Olejnik KT, Yesilyurt V, Chen D, Barros S, Klebanov B, Novobrantseva T, Langer R, Anderson DG.

Nat Commun. 2014 Jun 27;5:4277. doi: 10.1038/ncomms5277.

PMID:
24969323
[PubMed - in process]
4.

Silencing of CCR2 in myocarditis.

Leuschner F, Courties G, Dutta P, Mortensen LJ, Gorbatov R, Sena B, Novobrantseva TI, Borodovsky A, Fitzgerald K, Koteliansky V, Iwamoto Y, Bohlender M, Meyer S, Lasitschka F, Meder B, Katus HA, Lin C, Libby P, Swirski FK, Anderson DG, Weissleder R, Nahrendorf M.

Eur Heart J. 2014 Jun 20. pii: ehu225. [Epub ahead of print]

PMID:
24950695
[PubMed - as supplied by publisher]
5.

Technology: Investment suggests RNAi is on the up.

Maraganore J.

Nature. 2014 Jun 5;510(7503):35. doi: 10.1038/510035b. No abstract available.

PMID:
24899296
[PubMed - in process]
6.

RNAi-mediated silencing of hepatic Alas1 effectively prevents and treats the induced acute attacks in acute intermittent porphyria mice.

Yasuda M, Gan L, Chen B, Kadirvel S, Yu C, Phillips JD, New MI, Liebow A, Fitzgerald K, Querbes W, Desnick RJ.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7777-82. doi: 10.1073/pnas.1406228111. Epub 2014 May 12.

PMID:
24821812
[PubMed - in process]
Free PMC Article
7.

In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight.

Dahlman JE, Barnes C, Khan OF, Thiriot A, Jhunjunwala S, Shaw TE, Xing Y, Sager HB, Sahay G, Speciner L, Bader A, Bogorad RL, Yin H, Racie T, Dong Y, Jiang S, Seedorf D, Dave A, Singh Sandhu K, Webber MJ, Novobrantseva T, Ruda VM, Lytton-Jean AK, Levins CG, Kalish B, Mudge DK, Perez M, Abezgauz L, Dutta P, Smith L, Charisse K, Kieran MW, Fitzgerald K, Nahrendorf M, Danino D, Tuder RM, von Andrian UH, Akinc A, Panigrahy D, Schroeder A, Koteliansky V, Langer R, Anderson DG.

Nat Nanotechnol. 2014 May 11. doi: 10.1038/nnano.2014.84. [Epub ahead of print]

PMID:
24813696
[PubMed - as supplied by publisher]
8.

In vivo silencing of the transcription factor IRF5 reprograms the macrophage phenotype and improves infarct healing.

Courties G, Heidt T, Sebas M, Iwamoto Y, Jeon D, Truelove J, Tricot B, Wojtkiewicz G, Dutta P, Sager HB, Borodovsky A, Novobrantseva T, Klebanov B, Fitzgerald K, Anderson DG, Libby P, Swirski FK, Weissleder R, Nahrendorf M.

J Am Coll Cardiol. 2014 Apr 22;63(15):1556-66. doi: 10.1016/j.jacc.2013.11.023. Epub 2013 Dec 18.

PMID:
24361318
[PubMed - indexed for MEDLINE]
9.

Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles.

Mui BL, Tam YK, Jayaraman M, Ansell SM, Du X, Tam YY, Lin PJ, Chen S, Narayanannair JK, Rajeev KG, Manoharan M, Akinc A, Maier MA, Cullis P, Madden TD, Hope MJ.

Mol Ther Nucleic Acids. 2013 Dec 17;2:e139. doi: 10.1038/mtna.2013.66.

PMID:
24345865
[PubMed]
Free PMC Article
10.

Exploiting endocytosis for nanomedicines.

Akinc A, Battaglia G.

Cold Spring Harb Perspect Biol. 2013 Nov 1;5(11):a016980. doi: 10.1101/cshperspect.a016980. Review.

PMID:
24186069
[PubMed - indexed for MEDLINE]
11.

Measuring RNAi knockdown using qPCR.

Milstein S, Nguyen M, Meyers R, de Fougerolles A.

Methods Enzymol. 2013;533:57-77. doi: 10.1016/B978-0-12-420067-8.00006-4.

PMID:
24182918
[PubMed - in process]
12.

Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial.

Fitzgerald K, Frank-Kamenetsky M, Shulga-Morskaya S, Liebow A, Bettencourt BR, Sutherland JE, Hutabarat RM, Clausen VA, Karsten V, Cehelsky J, Nochur SV, Kotelianski V, Horton J, Mant T, Chiesa J, Ritter J, Munisamy M, Vaishnaw AK, Gollob JA, Simon A.

Lancet. 2014 Jan 4;383(9911):60-8. doi: 10.1016/S0140-6736(13)61914-5. Epub 2013 Oct 3.

PMID:
24094767
[PubMed - indexed for MEDLINE]
13.

Promoter RNA links transcriptional regulation of inflammatory pathway genes.

Matsui M, Chu Y, Zhang H, Gagnon KT, Shaikh S, Kuchimanchi S, Manoharan M, Corey DR, Janowski BA.

Nucleic Acids Res. 2013 Dec;41(22):10086-109. doi: 10.1093/nar/gkt777. Epub 2013 Sep 2.

PMID:
23999091
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

RNA duplexes with abasic substitutions are potent and allele-selective inhibitors of huntingtin and ataxin-3 expression.

Liu J, Pendergraff H, Narayanannair KJ, Lackey JG, Kuchimanchi S, Rajeev KG, Manoharan M, Hu J, Corey DR.

Nucleic Acids Res. 2013 Oct;41(18):8788-801. doi: 10.1093/nar/gkt594. Epub 2013 Jul 24.

PMID:
23887934
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics.

Maier MA, Jayaraman M, Matsuda S, Liu J, Barros S, Querbes W, Tam YK, Ansell SM, Kumar V, Qin J, Zhang X, Wang Q, Panesar S, Hutabarat R, Carioto M, Hettinger J, Kandasamy P, Butler D, Rajeev KG, Pang B, Charisse K, Fitzgerald K, Mui BL, Du X, Cullis P, Madden TD, Hope MJ, Manoharan M, Akinc A.

Mol Ther. 2013 Aug;21(8):1570-8. doi: 10.1038/mt.2013.124. Epub 2013 Jun 25.

PMID:
23799535
[PubMed - indexed for MEDLINE]
16.

Liver as a target for oligonucleotide therapeutics.

Sehgal A, Vaishnaw A, Fitzgerald K.

J Hepatol. 2013 Dec;59(6):1354-9. doi: 10.1016/j.jhep.2013.05.045. Epub 2013 Jun 12.

PMID:
23770039
[PubMed - in process]
Free Article
17.

Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells.

Novobrantseva TI, Borodovsky A, Wong J, Klebanov B, Zafari M, Yucius K, Querbes W, Ge P, Ruda VM, Milstein S, Speciner L, Duncan R, Barros S, Basha G, Cullis P, Akinc A, Donahoe JS, Narayanannair Jayaprakash K, Jayaraman M, Bogorad RL, Love K, Whitehead K, Levins C, Manoharan M, Swirski FK, Weissleder R, Langer R, Anderson DG, de Fougerolles A, Nahrendorf M, Koteliansky V.

Mol Ther Nucleic Acids. 2012 Jan 24;1:e4. doi: 10.1038/mtna.2011.3.

PMID:
23344621
[PubMed]
Free PMC Article
18.

Automated parallel synthesis of 5'-triphosphate oligonucleotides and preparation of chemically modified 5'-triphosphate small interfering RNA.

Zlatev I, Lackey JG, Zhang L, Dell A, McRae K, Shaikh S, Duncan RG, Rajeev KG, Manoharan M.

Bioorg Med Chem. 2013 Feb 1;21(3):722-32. doi: 10.1016/j.bmc.2012.11.043. Epub 2012 Dec 3.

PMID:
23260577
[PubMed - indexed for MEDLINE]
19.

Evaluation of exogenous siRNA addition as a metabolic engineering tool for modifying biopharmaceuticals.

Tummala S, Titus M, Wilson L, Wang C, Ciatto C, Thill G, Foster D, Li C, Szabo Z, Guttman A, Bettencourt B, Jayaraman M, Deroot J, Kocisko D, Pollard S, Charisse K, Kuchimanchi S, Hinkle G, Milstein S, Meyers R, Wu SL, Karger BL, Rossomando A.

Biotechnol Prog. 2013 Mar-Apr;29(2):415-24. doi: 10.1002/btpr.1667. Epub 2013 Feb 13.

PMID:
23172735
[PubMed - indexed for MEDLINE]
20.

An immobilized and reusable Cu(I) catalyst for metal ion-free conjugation of ligands to fully deprotected oligonucleotides through click reaction.

Eltepu L, Jayaraman M, Rajeev KG, Manoharan M.

Chem Commun (Camb). 2013 Jan 7;49(2):184-6. doi: 10.1039/c2cc36811k. Epub 2012 Nov 21.

PMID:
23172132
[PubMed - indexed for MEDLINE]

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