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Items: 1 to 20 of 91

1.

A novel LC-MS/MS assay for heparan sulfate screening in the cerebrospinal fluid of mucopolysaccharidosis IIIA patients.

Naimy H, Powell KD, Moriarity JR, Wu J, McCauley TG, Haslett PA, Barbier AJ, Qiu Y.

Bioanalysis. 2016 Feb 5. [Epub ahead of print]

PMID:
26847798
2.

Dectin-1 Controls TLR9 Trafficking to Phagosomes Containing β-1,3 Glucan.

Khan NS, Kasperkovitz PV, Timmons AK, Mansour MK, Tam JM, Seward MW, Reedy JL, Puranam S, Feliu M, Vyas JM.

J Immunol. 2016 Feb 1. pii: 1401545. [Epub ahead of print]

PMID:
26829985
3.

Role of Receptor Occupancy Assays by Flow Cytometry in Drug Development.

Stewart JJ, Green CL, Jones N, Liang M, Xu Y, Wilkins DE, Moulard M, Czechowska K, Lanham D, Mc Closkey TW, Ferbas J, van der Strate BW, Högerkorp CM, Wyant T, Lackey A, Litwin V.

Cytometry B Clin Cytom. 2015 Dec 24. doi: 10.1002/cyto.b.21355. [Epub ahead of print]

PMID:
26704557
4.

5'-C-Malonyl RNA: Small Interfering RNAs Modified with 5'-Monophosphate Bioisostere Demonstrate Gene Silencing Activity.

Zlatev I, Foster DJ, Liu J, Charisse K, Brigham B, Parmar RG, Jadhav V, Maier MA, Rajeev KG, Egli M, Manoharan M.

ACS Chem Biol. 2016 Jan 13. [Epub ahead of print]

PMID:
26675211
5.

Delayed-Release Dimethyl Fumarate and Pregnancy: Preclinical Studies and Pregnancy Outcomes from Clinical Trials and Postmarketing Experience.

Gold R, Phillips JT, Havrdova E, Bar-Or A, Kappos L, Kim N, Thullen T, Valencia P, Oliva L, Novas M, Li J, Sweetser MT, Kurukulasuriya N, Viglietta V, Fox RJ.

Neurol Ther. 2015 Dec;4(2):93-104. doi: 10.1007/s40120-015-0033-1. Epub 2015 Oct 12.

6.

Control of liver size by RNAi-mediated multiplex knockdown and its application for discovery of regulatory mechanisms.

Yin H, Bogorad RL, Barnes C, Walsh S, Zhuang I, Nonaka H, Ruda V, Kuchimanchi S, Nechev L, Akinc A, Xue W, Zerial M, Langer R, Anderson DG, Koteliansky V.

J Hepatol. 2015 Nov 30. pii: S0168-8278(15)00786-2. doi: 10.1016/j.jhep.2015.11.028. [Epub ahead of print]

PMID:
26658687
7.

Metabolism of (13)C5-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase.

Li X, Knight J, Fargue S, Buchalski B, Guan Z, Inscho EW, Liebow A, Fitzgerald K, Querbes W, Todd Lowther W, Holmes RP.

Biochim Biophys Acta. 2016 Feb;1862(2):233-9. doi: 10.1016/j.bbadis.2015.12.001. Epub 2015 Dec 2.

PMID:
26655602
8.

Strain- and Diet-Related Lesion Variability in Aging DBA/2, C57BL/6, and DBA/2xC57BL/6 F1 Mice.

Harbison CE, Lipman RD, Bronson RT.

Vet Pathol. 2015 Nov 24. pii: 0300985815612152. [Epub ahead of print]

PMID:
26604215
9.

Recommendations for the development and validation of flow cytometry-based receptor occupancy assays.

Green CL, Stewart JJ, Högerkorp CM, Lackey A, Jones N, Liang M, Xu Y, Ferbas J, Moulard M, Czechowska K, Mc Closkey TW, van der Strate BW, Wilkins DE, Lanham D, Wyant T, Litwin V.

Cytometry B Clin Cytom. 2015 Nov 13. doi: 10.1002/cyto.b.21339. [Epub ahead of print] Review.

PMID:
26566147
10.

Preclinical Development of a Subcutaneous ALAS1 RNAi Therapeutic for Treatment of Hepatic Porphyrias Using Circulating RNA Quantification.

Chan A, Liebow A, Yasuda M, Gan L, Racie T, Maier M, Kuchimanchi S, Foster D, Milstein S, Charisse K, Sehgal A, Manoharan M, Meyers R, Fitzgerald K, Simon A, Desnick RJ, Querbes W.

Mol Ther Nucleic Acids. 2015 Nov 3;4:e263. doi: 10.1038/mtna.2015.36.

PMID:
26528940
11.

Serial scanning with technetium pyrophosphate (99mTc-PYP) in advanced ATTR cardiac amyloidosis.

Castaño A, DeLuca A, Weinberg R, Pozniakoff T, Blaner WS, Pirmohamed A, Bettencourt B, Gollob J, Karsten V, Vest JA, Chiuzan C, Maurer MS, Bokhari S.

J Nucl Cardiol. 2015 Oct 9. [Epub ahead of print]

PMID:
26453570
12.

ALN-RSV01 for prevention of bronchiolitis obliterans syndrome after respiratory syncytial virus infection in lung transplant recipients.

Gottlieb J, Zamora MR, Hodges T, Musk AW, Sommerwerk U, Dilling D, Arcasoy S, DeVincenzo J, Karsten V, Shah S, Bettencourt BR, Cehelsky J, Nochur S, Gollob J, Vaishnaw A, Simon AR, Glanville AR.

J Heart Lung Transplant. 2015 Sep 3. pii: S1053-2498(15)01387-X. doi: 10.1016/j.healun.2015.08.012. [Epub ahead of print]

PMID:
26452996
13.

Temporal Patterns of Novel Circulating Biomarkers in IL-2-mediated Vascular Injury in the Rat.

Keirstead ND, Bertinetti-Lapatki C, Knapp D, Albassam M, Hughes V, Hong F, Roth AB, Mikaelian I.

Toxicol Pathol. 2015 Oct;43(7):984-94. doi: 10.1177/0192623315601245. Epub 2015 Sep 8.

PMID:
26353978
14.

Efficacy and safety of patisiran for familial amyloidotic polyneuropathy: a phase II multi-dose study.

Suhr OB, Coelho T, Buades J, Pouget J, Conceicao I, Berk J, Schmidt H, Waddington-Cruz M, Campistol JM, Bettencourt BR, Vaishnaw A, Gollob J, Adams D.

Orphanet J Rare Dis. 2015 Sep 4;10:109. doi: 10.1186/s13023-015-0326-6.

15.

Small molecule inhibitors of Late SV40 Factor (LSF) abrogate hepatocellular carcinoma (HCC): Evaluation using an endogenous HCC model.

Rajasekaran D, Siddiq A, Willoughby JL, Biagi JM, Christadore LM, Yunes SA, Gredler R, Jariwala N, Robertson CL, Akiel MA, Shen XN, Subler MA, Windle JJ, Schaus SE, Fisher PB, Hansen U, Sarkar D.

Oncotarget. 2015 Sep 22;6(28):26266-77. doi: 10.18632/oncotarget.4656.

16.

Identification of siRNA delivery enhancers by a chemical library screen.

Gilleron J, Paramasivam P, Zeigerer A, Querbes W, Marsico G, Andree C, Seifert S, Amaya P, Stöter M, Koteliansky V, Waldmann H, Fitzgerald K, Kalaidzidis Y, Akinc A, Maier MA, Manoharan M, Bickle M, Zerial M.

Nucleic Acids Res. 2015 Sep 18;43(16):7984-8001. doi: 10.1093/nar/gkv762. Epub 2015 Jul 28.

17.

Rapid progression of familial amyloidotic polyneuropathy: a multinational natural history study.

Adams D, Coelho T, Obici L, Merlini G, Mincheva Z, Suanprasert N, Bettencourt BR, Gollob JA, Gandhi PJ, Litchy WJ, Dyck PJ.

Neurology. 2015 Aug 25;85(8):675-82. doi: 10.1212/WNL.0000000000001870. Epub 2015 Jul 24.

PMID:
26208957
18.

Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown.

Wittrup A, Ai A, Liu X, Hamar P, Trifonova R, Charisse K, Manoharan M, Kirchhausen T, Lieberman J.

Nat Biotechnol. 2015 Aug;33(8):870-6. doi: 10.1038/nbt.3298. Epub 2015 Jul 20.

19.

Onset Time and Durability of Huntingtin Suppression in Rhesus Putamen After Direct Infusion of Antihuntingtin siRNA.

Grondin R, Ge P, Chen Q, Sutherland JE, Zhang Z, Gash DM, Stiles DK, Stewart GR, Sah DW, Kaemmerer WF.

Mol Ther Nucleic Acids. 2015 Jun 30;4:e245. doi: 10.1038/mtna.2015.20.

20.

Specific hepatic delivery of procollagen α1(I) small interfering RNA in lipid-like nanoparticles resolves liver fibrosis.

Jiménez Calvente C, Sehgal A, Popov Y, Kim YO, Zevallos V, Sahin U, Diken M, Schuppan D.

Hepatology. 2015 Oct;62(4):1285-97. doi: 10.1002/hep.27936. Epub 2015 Aug 28.

PMID:
26096209
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