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Results: 1 to 20 of 215

1.

The WNK-SPAK/OSR1 pathway: Master regulator of cation-chloride cotransporters.

Alessi DR, Zhang J, Khanna A, Hochdörfer T, Shang Y, Kahle KT.

Sci Signal. 2014 Jul 15;7(334):re3. Review.

PMID:
25028718
[PubMed - as supplied by publisher]
2.

Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase.

Banerjee S, Zagórska A, Deak M, Campbell DG, Prescott AR, Alessi DR.

Biochem J. 2014 Jul 15;461(2):233-45. doi: 10.1042/BJ20140408.

PMID:
24785407
[PubMed - in process]
3.

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65.

Kazlauskaite A, Kondapalli C, Gourlay R, Campbell DG, Ritorto MS, Hofmann K, Alessi DR, Knebel A, Trost M, Muqit MM.

Biochem J. 2014 May 15;460(1):127-39. doi: 10.1042/BJ20140334.

PMID:
24660806
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction.

van der Wijst J, Blanchard MG, Woodroof HI, Macartney TJ, Gourlay R, Hoenderop JG, Bindels RJ, Alessi DR.

Biochem J. 2014 Jun 1;460(2):165-75. doi: 10.1042/BJ20131639.

PMID:
24650431
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity.

Kazlauskaite A, Kelly V, Johnson C, Baillie C, Hastie CJ, Peggie M, Macartney T, Woodroof HI, Alessi DR, Pedrioli PG, Muqit MM.

Open Biol. 2014 Mar 19;4:130213. doi: 10.1098/rsob.130213.

PMID:
24647965
[PubMed - in process]
Free PMC Article
6.

Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation.

Schumacher FR, Sorrell FJ, Alessi DR, Bullock AN, Kurz T.

Biochem J. 2014 Jun 1;460(2):237-46. doi: 10.1042/BJ20140153.

PMID:
24641320
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters.

de Los Heros P, Alessi DR, Gourlay R, Campbell DG, Deak M, Macartney TJ, Kahle KT, Zhang J.

Biochem J. 2014 Mar 15;458(3):559-73. doi: 10.1042/BJ20131478.

PMID:
24393035
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity.

Houde VP, Ritorto MS, Gourlay R, Varghese J, Davies P, Shpiro N, Sakamoto K, Alessi DR.

Biochem J. 2014 Feb 15;458(1):41-56. doi: 10.1042/BJ20131324.

PMID:
24295069
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones.

Deng X, Elkins JM, Zhang J, Yang Q, Erazo T, Gomez N, Choi HG, Wang J, Dzamko N, Lee JD, Sim T, Kim N, Alessi DR, Lizcano JM, Knapp S, Gray NS.

Eur J Med Chem. 2013;70:758-67. doi: 10.1016/j.ejmech.2013.10.052. Epub 2013 Oct 29.

PMID:
24239623
[PubMed - in process]
Free PMC Article
10.

Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases.

Banerjee S, Buhrlage SJ, Huang HT, Deng X, Zhou W, Wang J, Traynor R, Prescott AR, Alessi DR, Gray NS.

Biochem J. 2014 Jan 1;457(1):215-25. doi: 10.1042/BJ20131152.

PMID:
24171924
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

N-terminal serine dephosphorylation is required for KCC3 cotransporter full activation by cell swelling.

Melo Z, de los Heros P, Cruz-Rangel S, Vázquez N, Bobadilla NA, Pasantes-Morales H, Alessi DR, Mercado A, Gamba G.

J Biol Chem. 2013 Nov 1;288(44):31468-76. doi: 10.1074/jbc.M113.475574. Epub 2013 Sep 16.

PMID:
24043619
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Structural biology: Security measures of a master regulator.

Alessi DR, Kulathu Y.

Nature. 2013 May 9;497(7448):193-4. doi: 10.1038/nature12101. Epub 2013 May 1. No abstract available.

PMID:
23636322
[PubMed - indexed for MEDLINE]
13.

LKB1 and AMPK and the cancer-metabolism link - ten years after.

Hardie DG, Alessi DR.

BMC Biol. 2013 Apr 15;11:36. doi: 10.1186/1741-7007-11-36. Review.

PMID:
23587167
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors.

Sommer EM, Dry H, Cross D, Guichard S, Davies BR, Alessi DR.

Biochem J. 2013 Jun 15;452(3):499-508. doi: 10.1042/BJ20130342.

PMID:
23581296
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies.

Davies P, Hinkle KM, Sukar NN, Sepulveda B, Mesias R, Serrano G, Alessi DR, Beach TG, Benson DL, White CL, Cowell RM, Das SS, West AB, Melrose HL.

Biochem J. 2013 Jul 1;453(1):101-13. doi: 10.1042/BJ20121742.

PMID:
23560750
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer.

Eser S, Reiff N, Messer M, Seidler B, Gottschalk K, Dobler M, Hieber M, Arbeiter A, Klein S, Kong B, Michalski CW, Schlitter AM, Esposito I, Kind AJ, Rad L, Schnieke AE, Baccarini M, Alessi DR, Rad R, Schmid RM, Schneider G, Saur D.

Cancer Cell. 2013 Mar 18;23(3):406-20. doi: 10.1016/j.ccr.2013.01.023. Epub 2013 Feb 28.

PMID:
23453624
[PubMed - indexed for MEDLINE]
Free Article
17.

The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.

Ohta A, Schumacher FR, Mehellou Y, Johnson C, Knebel A, Macartney TJ, Wood NT, Alessi DR, Kurz T.

Biochem J. 2013 Apr 1;451(1):111-22. doi: 10.1042/BJ20121903.

PMID:
23387299
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation.

Delbroek L, Van Kolen K, Steegmans L, da Cunha R, Mandemakers W, Daneels G, De Bock PJ, Zhang J, Gevaert K, De Strooper B, Alessi DR, Verstreken P, Moechars DW.

J Pharm Biomed Anal. 2013 Mar 25;76:49-58. doi: 10.1016/j.jpba.2012.12.002. Epub 2012 Dec 16.

PMID:
23313773
[PubMed - indexed for MEDLINE]
19.

Structural insights into the activation of MST3 by MO25.

Mehellou Y, Alessi DR, Macartney TJ, Szklarz M, Knapp S, Elkins JM.

Biochem Biophys Res Commun. 2013 Feb 15;431(3):604-9. doi: 10.1016/j.bbrc.2012.12.113. Epub 2013 Jan 4.

PMID:
23296203
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Kinase drug discovery--what's next in the field?

Cohen P, Alessi DR.

ACS Chem Biol. 2013 Jan 18;8(1):96-104. doi: 10.1021/cb300610s. Epub 2012 Dec 31. Erratum in: ACS Chem Biol. 2013 Feb 15;8(2):464.

PMID:
23276252
[PubMed - indexed for MEDLINE]

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