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Items: 1 to 20 of 21


Dissection of the radical reactions linked to fetal hemoglobin reveals enhanced pseudoperoxidase activity.

Ratanasopa K, Strader MB, Alayash AI, Bulow L.

Front Physiol. 2015 Feb 20;6:39. doi: 10.3389/fphys.2015.00039. eCollection 2015.


Characterization of heme binding to recombinant α1-microglobulin.

Karnaukhova E, Rutardottir S, Rajabi M, Wester Rosenlöf L, Alayash AI, Åkerström B.

Front Physiol. 2014 Dec 4;5:465. doi: 10.3389/fphys.2014.00465. eCollection 2014.


Blood substitutes: why haven't we been more successful?

Alayash AI.

Trends Biotechnol. 2014 Apr;32(4):177-85. doi: 10.1016/j.tibtech.2014.02.006. Epub 2014 Mar 12. Review.


Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin.

Mollan TL, Jia Y, Banerjee S, Wu G, Kreulen RT, Tsai AL, Olson JS, Crumbliss AL, Alayash AI.

Free Radic Biol Med. 2014 Apr;69:265-77. doi: 10.1016/j.freeradbiomed.2014.01.030. Epub 2014 Jan 30.


Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease.

Belcher JD, Chen C, Nguyen J, Milbauer L, Abdulla F, Alayash AI, Smith A, Nath KA, Hebbel RP, Vercellotti GM.

Blood. 2014 Jan 16;123(3):377-90. doi: 10.1182/blood-2013-04-495887. Epub 2013 Nov 25.


Haptoglobin preferentially binds β but not α subunits cross-linked hemoglobin tetramers with minimal effects on ligand and redox reactions.

Jia Y, Wood F, Buehler PW, Alayash AI.

PLoS One. 2013;8(3):e59841. doi: 10.1371/journal.pone.0059841. Epub 2013 Mar 29.


Redox reactions of hemoglobin: mechanisms of toxicity and control.

Mollan TL, Alayash AI.

Antioxid Redox Signal. 2013 Jun 10;18(17):2251-3. doi: 10.1089/ars.2013.5195. Epub 2013 Feb 28.


α-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of α-subunits of human HbA with hydrogen peroxide.

Mollan TL, Banerjee S, Wu G, Parker Siburt CJ, Tsai AL, Olson JS, Weiss MJ, Crumbliss AL, Alayash AI.

J Biol Chem. 2013 Feb 8;288(6):4288-98. doi: 10.1074/jbc.M112.412064. Epub 2012 Dec 21.


Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins.

Schaer DJ, Buehler PW, Alayash AI, Belcher JD, Vercellotti GM.

Blood. 2013 Feb 21;121(8):1276-84. doi: 10.1182/blood-2012-11-451229. Epub 2012 Dec 20. Review.


Molecular controls of the oxygenation and redox reactions of hemoglobin.

Bonaventura C, Henkens R, Alayash AI, Banerjee S, Crumbliss AL.

Antioxid Redox Signal. 2013 Jun 10;18(17):2298-313. doi: 10.1089/ars.2012.4947. Epub 2013 Jan 21. Review.


Familial secondary erythrocytosis due to increased oxygen affinity is caused by destabilization of the T state of hemoglobin Brigham (α₂β₂(Pro100Leu)).

Mollan TL, Abraham B, Strader MB, Jia Y, Lozier JN, Olson JS, Alayash AI.

Protein Sci. 2012 Oct;21(10):1444-55. doi: 10.1002/pro.2130. Epub 2012 Aug 21.


Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine β145.

Cooper CE, Schaer DJ, Buehler PW, Wilson MT, Reeder BJ, Silkstone G, Svistunenko DA, Bulow L, Alayash AI.

Antioxid Redox Signal. 2013 Jun 10;18(17):2264-73. doi: 10.1089/ars.2012.4547. Epub 2012 Aug 6.


Enhanced nitrite reductase activity associated with the haptoglobin complexed hemoglobin dimer: functional and antioxidative implications.

Roche CJ, Dantsker D, Alayash AI, Friedman JM.

Nitric Oxide. 2012 Jun 30;27(1):32-9. doi: 10.1016/j.niox.2012.04.002. Epub 2012 Apr 18.


Effects of carbon monoxide (CO) delivery by a CO donor or hemoglobin on vascular hypoxia inducible factor 1α and mitochondrial respiration.

Reiter CE, Alayash AI.

FEBS Open Bio. 2012 May 24;2:113-8. doi: 10.1016/j.fob.2012.05.003. Print 2012.


Slow histidine H/D exchange protocol for thermodynamic analysis of protein folding and stability using mass spectrometry.

Tran DT, Banerjee S, Alayash AI, Crumbliss AL, Fitzgerald MC.

Anal Chem. 2012 Feb 7;84(3):1653-60. doi: 10.1021/ac202927p. Epub 2012 Jan 18.


Extreme differences between hemoglobins I and II of the clam Lucina pectinalis in their reactions with nitrite.

Bonaventura C, Henkens R, De Jesus-Bonilla W, Lopez-Garriga J, Jia Y, Alayash AI, Siburt CJ, Crumbliss AL.

Biochim Biophys Acta. 2010 Oct;1804(10):1988-95. doi: 10.1016/j.bbapap.2010.06.016. Epub 2010 Jul 1.


Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs.

Boretti FS, Buehler PW, D'Agnillo F, Kluge K, Glaus T, Butt OI, Jia Y, Goede J, Pereira CP, Maggiorini M, Schoedon G, Alayash AI, Schaer DJ.

J Clin Invest. 2009 Aug;119(8):2271-80. doi: 10.1172/JCI39115. Epub 2009 Jul 20.


Mixed S-nitrosylated polymerized bovine hemoglobin species moderate hemodynamic effects in acutely hypoxic rats.

Irwin D, Buehler PW, Alayash AI, Jia Y, Bonventura J, Foreman B, White M, Jacobs R, Piteo B, TissotvanPatot MC, Hamilton KL, Gotshall RW.

Am J Respir Cell Mol Biol. 2010 Feb;42(2):200-9. doi: 10.1165/rcmb.2008-0364OC. Epub 2009 Apr 24.


Ascorbate removes key precursors to oxidative damage by cell-free haemoglobin in vitro and in vivo.

Dunne J, Caron A, Menu P, Alayash AI, Buehler PW, Wilson MT, Silaghi-Dumitrescu R, Faivre B, Cooper CE.

Biochem J. 2006 Nov 1;399(3):513-24.


Cross-linking with O-raffinose lowers oxygen affinity and stabilizes haemoglobin in a non-cooperative T-state conformation.

Jia Y, Ramasamy S, Wood F, Alayash AI, Rifkind JM.

Biochem J. 2004 Dec 1;384(Pt 2):367-75. Erratum in: Biochem J. 2005 Feb 1;385(Pt 3):839.

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