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Items: 1 to 20 of 159

1.

Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain.

Kurbatskaya K, Phillips EC, Croft CL, Dentoni G, Hughes MM, Wade MA, Al-Sarraj S, Troakes C, O'Neill MJ, Perez-Nievas BG, Hanger DP, Noble W.

Acta Neuropathol Commun. 2016 Mar 31;4:34. doi: 10.1186/s40478-016-0299-2.

2.

Retention of hexanucleotide repeat-containing intron in C9orf72 mRNA: implications for the pathogenesis of ALS/FTD.

Niblock M, Smith BN, Lee YB, Sardone V, Topp S, Troakes C, Al-Sarraj S, Leblond CS, Dion PA, Rouleau GA, Shaw CE, Gallo JM.

Acta Neuropathol Commun. 2016 Feb 25;4:18. doi: 10.1186/s40478-016-0289-4.

3.

Variation in 5-hydroxymethylcytosine across human cortex and cerebellum.

Lunnon K, Hannon E, Smith RG, Dempster E, Wong C, Burrage J, Troakes C, Al-Sarraj S, Kepa A, Schalkwyk L, Mill J.

Genome Biol. 2016 Feb 16;17(1):27. doi: 10.1186/s13059-016-0871-x.

4.

Has the survival of patients with glioblastoma changed over the years?

deSouza RM, Shaweis H, Han C, Sivasubramiam V, Brazil L, Beaney R, Sadler G, Al-Sarraj S, Hampton T, Logan J, Hurwitz V, Bhangoo R, Gullan R, Ashkan K.

Br J Cancer. 2016 Jan 19;114(2):146-50. doi: 10.1038/bjc.2015.421. Epub 2015 Dec 15.

PMID:
26671748
5.

Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases.

Guerreiro R, Escott-Price V, Darwent L, Parkkinen L, Ansorge O, Hernandez DG, Nalls MA, Clark L, Honig L, Marder K, van der Flier W, Holstege H, Louwersheimer E, Lemstra A, Scheltens P, Rogaeva E, St George-Hyslop P, Londos E, Zetterberg H, Ortega-Cubero S, Pastor P, Ferman TJ, Graff-Radford NR, Ross OA, Barber I, Braae A, Brown K, Morgan K, Maetzler W, Berg D, Troakes C, Al-Sarraj S, Lashley T, Compta Y, Revesz T, Lees A, Cairns NJ, Halliday GM, Mann D, Pickering-Brown S, Powell J, Lunnon K, Lupton MK; International Parkinson's Disease Genomics Consortium (IPDGC), Dickson D, Hardy J, Singleton A, Bras J.

Neurobiol Aging. 2016 Feb;38:214.e7-214.e10. doi: 10.1016/j.neurobiolaging.2015.10.028. Epub 2015 Nov 2.

6.

Lack of association between TDP-43 pathology and tau mis-splicing in Alzheimer's disease.

Niblock M, Hortobágyi T, Troakes C, Al-Sarraj S, Spickett C, Jones R, Shaw CE, Gallo JM.

Neurobiol Aging. 2016 Jan;37:45-6. doi: 10.1016/j.neurobiolaging.2015.09.022. Epub 2015 Oct 9.

7.

A comparison of mitochondrial DNA isolation methods in frozen post-mortem human brain tissue--applications for studies of mitochondrial genetics in brain disorders.

Devall M, Burrage J, Caswell R, Johnson M, Troakes C, Al-Sarraj S, Jeffries AR, Mill J, Lunnon K.

Biotechniques. 2015 Oct 1;59(4):241-2, 244-6. doi: 10.2144/000114343. eCollection 2015 Oct.

8.

ALS-FUS pathology revisited: singleton FUS mutations and an unusual case with both a FUS and TARDBP mutation.

King A, Troakes C, Smith B, Nolan M, Curran O, Vance C, Shaw CE, Al-Sarraj S.

Acta Neuropathol Commun. 2015 Oct 9;3:62. doi: 10.1186/s40478-015-0235-x.

9.

The CHCHD10 P34S variant is not associated with ALS in a UK cohort of familial and sporadic patients.

Wong CH, Topp S, Gkazi AS, Troakes C, Miller JW, de Majo M, Kirby J, Shaw PJ, Morrison KE, de Belleroche J, Vance CA, Al-Chalabi A, Al-Sarraj S, Shaw CE, Smith BN.

Neurobiol Aging. 2015 Oct;36(10):2908.e17-8. doi: 10.1016/j.neurobiolaging.2015.07.014. Epub 2015 Jul 13.

PMID:
26344877
10.

Dipeptide repeat protein inclusions are rare in the spinal cord and almost absent from motor neurons in C9ORF72 mutant amyotrophic lateral sclerosis and are unlikely to cause their degeneration.

Gomez-Deza J, Lee YB, Troakes C, Nolan M, Al-Sarraj S, Gallo JM, Shaw CE.

Acta Neuropathol Commun. 2015 Jun 25;3:38. doi: 10.1186/s40478-015-0218-y.

11.

Assessment of the degree of asymmetry of pathological features in neurodegenerative diseases. What is the significance for brain banks?

King A, Bodi I, Nolan M, Troakes C, Al-Sarraj S.

J Neural Transm (Vienna). 2015 Oct;122(10):1499-508. doi: 10.1007/s00702-015-1410-8. Epub 2015 May 29.

PMID:
26021735
12.

Stratified gene expression analysis identifies major amyotrophic lateral sclerosis genes.

Jones AR, Troakes C, King A, Sahni V, De Jong S, Bossers K, Papouli E, Mirza M, Al-Sarraj S, Shaw CE, Shaw PJ, Kirby J, Veldink JH, Macklis JD, Powell JF, Al-Chalabi A.

Neurobiol Aging. 2015 May;36(5):2006.e1-9. doi: 10.1016/j.neurobiolaging.2015.02.017. Epub 2015 Feb 19.

PMID:
25801576
13.

Control tissue in brain banking: the importance of thorough neuropathological assessment.

Nolan M, Troakes C, King A, Bodi I, Al-Sarraj S.

J Neural Transm (Vienna). 2015 Jul;122(7):949-56. doi: 10.1007/s00702-015-1376-6. Epub 2015 Feb 12.

14.

Changes in the expression of genes related to neuroinflammation over the course of sporadic Alzheimer's disease progression: CX3CL1, TREM2, and PPARγ.

Strobel S, Grünblatt E, Riederer P, Heinsen H, Arzberger T, Al-Sarraj S, Troakes C, Ferrer I, Monoranu CM.

J Neural Transm (Vienna). 2015 Jul;122(7):1069-76. doi: 10.1007/s00702-015-1369-5. Epub 2015 Jan 18.

PMID:
25596843
15.

Impact commentaries. Subacute necrotising encephalomyelopathy (Leigh's disease; Leigh syndrome).

Leigh PN, Al-Sarraj S, DiMauro S.

J Neurol Neurosurg Psychiatry. 2015 Apr;86(4):363-5. doi: 10.1136/jnnp-2012-304601. Epub 2015 Jan 13. No abstract available.

16.

BrainNet Europe's Code of Conduct for brain banking.

Klioueva NM, Rademaker MC, Dexter DT, Al-Sarraj S, Seilhean D, Streichenberger N, Schmitz P, Bell JE, Ironside JW, Arzberger T, Huitinga I.

J Neural Transm (Vienna). 2015 Jul;122(7):937-40. doi: 10.1007/s00702-014-1353-5. Epub 2015 Jan 13.

17.

Active dendritic cell immunotherapy for glioblastoma: Current status and challenges.

Polyzoidis S, Tuazon J, Brazil L, Beaney R, Al-Sarraj ST, Doey L, Logan J, Hurwitz V, Jarosz J, Bhangoo R, Gullan R, Mijovic A, Richardson M, Farzaneh F, Ashkan K.

Br J Neurosurg. 2015 Apr;29(2):197-205. doi: 10.3109/02688697.2014.994473. Epub 2014 Dec 26. Review.

PMID:
25541743
18.

Mitochondrial abnormalities and low grade inflammation are present in the skeletal muscle of a minority of patients with amyotrophic lateral sclerosis; an observational myopathology study.

Al-Sarraj S, King A, Cleveland M, Pradat PF, Corse A, Rothstein JD, Leigh PN, Abila B, Bates S, Wurthner J, Meininger V.

Acta Neuropathol Commun. 2014 Dec 14;2:165. doi: 10.1186/s40478-014-0165-z.

19.

Expression of the chondroitin sulphate proteoglycan, NG2, in paediatric brain tumors.

Higgins SC, Bolteus AJ, Donovan LK, Hasegawa H, Doey L, Al Sarraj S, King A, Ashkan K, Roncaroli F, Fillmore HL, Pilkington GJ.

Anticancer Res. 2014 Dec;34(12):6919-24.

PMID:
25503117
20.

Novel mutations support a role for Profilin 1 in the pathogenesis of ALS.

Smith BN, Vance C, Scotter EL, Troakes C, Wong CH, Topp S, Maekawa S, King A, Mitchell JC, Lund K, Al-Chalabi A, Ticozzi N, Silani V, Sapp P, Brown RH Jr, Landers JE, Al-Sarraj S, Shaw CE.

Neurobiol Aging. 2015 Mar;36(3):1602.e17-27. doi: 10.1016/j.neurobiolaging.2014.10.032. Epub 2014 Oct 31.

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