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Results: 12

1.

Targeting HER-2 over expressed breast cancer cells with 2-cyclohexyl-N-[(Z)-(substituted phenyl/furan-2-yl/thiophene-2-yl)methylidene]hydrazinecarbothioamide.

Bhat MA, Al-Dhfyan A, Khan AA, Al-Harbi N, Manogaran PS, Alanazi AM, Fun HK, Al-Omar MA.

Bioorg Med Chem Lett. 2015 Jan 1;25(1):83-7. Epub 2014 Nov 10.

PMID:
25466196
2.

Fascin is involved in the chemotherapeutic resistance of breast cancer cells predominantly via the PI3K/Akt pathway.

Ghebeh H, Al-Khaldi S, Olabi S, Al-Dhfyan A, Al-Mohanna F, Barnawi R, Tulbah A, Al-Tweigeri T, Ajarim D, Al-Alwan M.

Br J Cancer. 2014 Oct 14;111(8):1552-61. doi: 10.1038/bjc.2014.453. Epub 2014 Aug 12.

3.

Synthesis and anti-Candidal activity of N-(4-aryl/cyclohexyl)-2-(pyridine-4-yl carbonyl) hydrazinecarbothioamide.

Bhat MA, Khan AA, Khan S, Al-Omar MA, Parvez MK, Al-Dosari MS, Al-Dhfyan A.

Bioorg Med Chem Lett. 2014 Mar 1;24(5):1299-302. doi: 10.1016/j.bmcl.2014.01.060. Epub 2014 Jan 30.

PMID:
24513049
4.

Chemoprevention of skin cancer using low HLB surfactant nanoemulsion of 5-fluorouracil: a preliminary study.

Shakeel F, Haq N, Al-Dhfyan A, Alanazi FK, Alsarra IA.

Drug Deliv. 2015 Jun;22(4):573-80. doi: 10.3109/10717544.2013.868557. Epub 2013 Dec 18.

PMID:
24350612
5.

Antiproliferative activity of novel thiophene and thienopyrimidine derivatives.

Ghorab MM, Al-Dhfyan A, Al-Dosari MS, El-Gazzar MG, AlSaid MS.

Drug Res (Stuttg). 2014 Jun;64(6):313-20. doi: 10.1055/s-0033-1358679. Epub 2013 Nov 13.

PMID:
24227473
6.

Synthesis and anticancer potential of certain novel 2-oxo-N'-(2-oxoindolin-3-ylidene)-2H-chromene-3-carbohydrazides.

Abdel-Aziz HA, Elsaman T, Al-Dhfyan A, Attia MI, Al-Rashood KA, Al-Obaid AR.

Eur J Med Chem. 2013;70:358-63. doi: 10.1016/j.ejmech.2013.09.060. Epub 2013 Oct 16.

PMID:
24177362
7.

Embryonic signature in breast cancers; Pluripotency roots of cancer stem cells.

Al-Dhfyan A.

Saudi Pharm J. 2013 Apr;21(2):229-32. doi: 10.1016/j.jsps.2012.08.001. Epub 2012 Aug 17.

8.

Synthesis, and docking studies of some fused-quinazolines and quinazolines carrying biological active isatin moiety as cell-cycle inhibitors of breast cancer cell lines.

Radwan AA, Alanazi FK, Al-Dhfyan A.

Drug Res (Stuttg). 2013 Mar;63(3):129-36. doi: 10.1055/s-0032-1333306. Epub 2013 Feb 26.

PMID:
23444171
9.

Design, synthesis and pharmacophoric model building of novel substituted nicotinic acid hydrazones with potential antiproliferative activity.

Abdel-Aziz HA, Aboul-Fadl T, Al-Obaid AR, Ghazzali M, Al-Dhfyan A, Contini A.

Arch Pharm Res. 2012 Sep;35(9):1543-52. doi: 10.1007/s12272-012-0904-2. Epub 2012 Oct 9.

PMID:
23054710
10.

Schiff bases of indoline-2,3-dione (isatin) with potential antiproliferative activity.

Aboul-Fadl T, Radwan AA, Attia MI, Al-Dhfyan A, Abdel-Aziz HA.

Chem Cent J. 2012 May 30;6(1):49. doi: 10.1186/1752-153X-6-49.

11.

3,5-disubstituted thiadiazine-2-thiones: new cell-cycle inhibitors.

Radwan AA, Al-Dhfyan A, Abdel-Hamid MK, Al-Badr AA, Aboul-Fadl T.

Arch Pharm Res. 2012 Jan;35(1):35-49. doi: 10.1007/s12272-012-0104-0. Epub 2012 Feb 2.

PMID:
22297741
12.

Cell cycle disruption and apoptotic activity of 3-aminothiazolo[3,2-a]benzimidazole-2-carbonitrile and its homologues.

Sarhan AA, Al-Dhfyan A, Al-Mozaini MA, Adra CN, Aboul-Fadl T.

Eur J Med Chem. 2010 Jun;45(6):2689-94. doi: 10.1016/j.ejmech.2010.02.025. Epub 2010 Feb 16.

PMID:
20226574
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