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    Results: 9

    1.

    Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation.

    Wang F, Travins J, DeLaBarre B, Penard-Lacronique V, Schalm S, Hansen E, Straley K, Kernytsky A, Liu W, Gliser C, Yang H, Gross S, Artin E, Saada V, Mylonas E, Quivoron C, Popovici-Muller J, Saunders JO, Salituro FG, Yan S, Murray S, Wei W, Gao Y, Dang L, Dorsch M, Agresta S, Schenkein DP, Biller SA, Su SM, de Botton S, Yen KE.

    Science. 2013 May 3;340(6132):622-6. doi: 10.1126/science.1234769. Epub 2013 Apr 4.

    PMID:
    23558173
    [PubMed - in process]
    2.

    Reevaluating the Accelerated Approval Process for Oncology Drugs.

    Wilson WH, Schenkein DP, Jernigan CL, Woodcock J, Schilsky RL.

    Clin Cancer Res. 2013 May 10. [Epub ahead of print]

    PMID:
    23553847
    [PubMed - as supplied by publisher]
    3.

    Small molecule activation of PKM2 in cancer cells induces serine auxotrophy.

    Kung C, Hixon J, Choe S, Marks K, Gross S, Murphy E, DeLaBarre B, Cianchetta G, Sethumadhavan S, Wang X, Yan S, Gao Y, Fang C, Wei W, Jiang F, Wang S, Qian K, Saunders J, Driggers E, Woo HK, Kunii K, Murray S, Yang H, Yen K, Liu W, Cantley LC, Vander Heiden MG, Su SM, Jin S, Salituro FG, Dang L.

    Chem Biol. 2012 Sep 21;19(9):1187-98. doi: 10.1016/j.chembiol.2012.07.021.

    PMID:
    22999886
    [PubMed - in process]
    4.

    Cancer-associated isocitrate dehydrogenase mutations.

    Yen KE, Schenkein DP.

    Oncologist. 2012;17(1):5-8. doi: 10.1634/theoncologist.2011-0429. Epub 2012 Jan 10. No abstract available.

    PMID:
    22234630
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    5.

    Full-length human glutaminase in complex with an allosteric inhibitor.

    DeLaBarre B, Gross S, Fang C, Gao Y, Jha A, Jiang F, Song J J, Wei W, Hurov JB.

    Biochemistry. 2011 Dec 20;50(50):10764-70. doi: 10.1021/bi201613d. Epub 2011 Nov 18.

    PMID:
    22049910
    [PubMed - indexed for MEDLINE]
    6.

    Cancer-associated IDH mutations: biomarker and therapeutic opportunities.

    Yen KE, Bittinger MA, Su SM, Fantin VR.

    Oncogene. 2010 Dec 9;29(49):6409-17. doi: 10.1038/onc.2010.444. Epub 2010 Oct 25. Review.

    PMID:
    20972461
    [PubMed - indexed for MEDLINE]
    7.

    IDH mutations in glioma and acute myeloid leukemia.

    Dang L, Jin S, Su SM.

    Trends Mol Med. 2010 Sep;16(9):387-97. doi: 10.1016/j.molmed.2010.07.002. Epub 2010 Aug 5. Review.

    PMID:
    20692206
    [PubMed - indexed for MEDLINE]
    8.

    Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations.

    Gross S, Cairns RA, Minden MD, Driggers EM, Bittinger MA, Jang HG, Sasaki M, Jin S, Schenkein DP, Su SM, Dang L, Fantin VR, Mak TW.

    J Exp Med. 2010 Feb 15;207(2):339-44. doi: 10.1084/jem.20092506. Epub 2010 Feb 8.

    PMID:
    20142433
    [PubMed - indexed for MEDLINE]
    Free PMC Article
    9.

    Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.

    Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, Rabinowitz JD, Cantley LC, Thompson CB, Vander Heiden MG, Su SM.

    Nature. 2009 Dec 10;462(7274):739-44. doi: 10.1038/nature08617. Epub .

    PMID:
    19935646
    [PubMed - indexed for MEDLINE]
    Free PMC Article

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