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Items: 1 to 20 of 43

1.

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.

Inoue S, Li WY, Tseng A, Beerman I, Elia AJ, Bendall SC, Lemonnier F, Kron KJ, Cescon DW, Hao Z, Lind EF, Takayama N, Planello AC, Shen SY, Shih AH, Larsen DM, Li Q, Snow BE, Wakeham A, Haight J, Gorrini C, Bassi C, Thu KL, Murakami K, Elford AR, Ueda T, Straley K, Yen KE, Melino G, Cimmino L, Aifantis I, Levine RL, De Carvalho DD, Lupien M, Rossi DJ, Nolan GP, Cairns RA, Mak TW.

Cancer Cell. 2016 Jul 9. pii: S1535-6108(16)30223-9. doi: 10.1016/j.ccell.2016.05.018. [Epub ahead of print]

PMID:
27424808
2.

Safe and Efficient Gene Therapy for Pyruvate Kinase Deficiency.

Garcia-Gomez M, Calabria A, Garcia-Bravo M, Benedicenti F, Kosinski P, López-Manzaneda S, Hill C, Del Mar Mañu-Pereira M, Martín MA, Orman I, Vives-Corrons JL, Kung C, Schambach A, Jin S, Bueren JA, Montini E, Navarro S, Segovia JC.

Mol Ther. 2016 Jun 14. doi: 10.1038/mt.2016.87. [Epub ahead of print]

PMID:
27138040
3.

GAM: a web-service for integrated transcriptional and metabolic network analysis.

Sergushichev AA, Loboda AA, Jha AK, Vincent EE, Driggers EM, Jones RG, Pearce EJ, Artyomov MN.

Nucleic Acids Res. 2016 Jul 8;44(W1):W194-200. doi: 10.1093/nar/gkw266. Epub 2016 Apr 20.

4.

MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis.

Marjon K, Cameron MJ, Quang P, Clasquin MF, Mandley E, Kunii K, McVay M, Choe S, Kernytsky A, Gross S, Konteatis Z, Murtie J, Blake ML, Travins J, Dorsch M, Biller SA, Marks KM.

Cell Rep. 2016 Apr 19;15(3):574-87. doi: 10.1016/j.celrep.2016.03.043. Epub 2016 Apr 7.

5.

A mouse model of a human congenital disorder of glycosylation caused by loss of PMM2.

Chan B, Clasquin M, Smolen GA, Histen G, Powe J, Chen Y, Lin Z, Lu C, Liu Y, Cang Y, Yan Z, Xia Y, Thompson R, Singleton C, Dorsch M, Silverman L, Su SM, Freeze HH, Jin S.

Hum Mol Genet. 2016 Apr 5. pii: ddw085. [Epub ahead of print]

6.

Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop.

Adams PD, Aertgeerts K, Bauer C, Bell JA, Berman HM, Bhat TN, Blaney JM, Bolton E, Bricogne G, Brown D, Burley SK, Case DA, Clark KL, Darden T, Emsley P, Feher VA, Feng Z, Groom CR, Harris SF, Hendle J, Holder T, Joachimiak A, Kleywegt GJ, Krojer T, Marcotrigiano J, Mark AE, Markley JL, Miller M, Minor W, Montelione GT, Murshudov G, Nakagawa A, Nakamura H, Nicholls A, Nicklaus M, Nolte RT, Padyana AK, Peishoff CE, Pieniazek S, Read RJ, Shao C, Sheriff S, Smart O, Soisson S, Spurlino J, Stouch T, Svobodova R, Tempel W, Terwilliger TC, Tronrud D, Velankar S, Ward SC, Warren GL, Westbrook JD, Williams P, Yang H, Young J.

Structure. 2016 Apr 5;24(4):502-8. doi: 10.1016/j.str.2016.02.017.

PMID:
27050687
7.

Potential mechanism of enhanced postprandial glucagon-like peptide-1 release following treatment with a diacylglycerol acyltransferase 1 inhibitor.

Liu J, McLaren DG, Chen D, Kan Y, Stout SJ, Shen X, Murphy BA, Forrest G, Karanam B, Sonatore L, He S, Roddy TP, Pinto S.

Pharmacol Res Perspect. 2015 Nov 30;3(6):e00193. eCollection 2015 Dec.

8.

The Use of Minipigs for Preclinical Safety Assessment by the Pharmaceutical Industry: Results of an IQ DruSafe Minipig Survey.

Colleton C, Brewster D, Chester A, Clarke DO, Heining P, Olaharski A, Graziano M.

Toxicol Pathol. 2016 Apr;44(3):458-66. doi: 10.1177/0192623315617562.

PMID:
27006130
9.

IDH mutations in cancer and progress toward development of targeted therapeutics.

Dang L, Yen K, Attar EC.

Ann Oncol. 2016 Apr;27(4):599-608. doi: 10.1093/annonc/mdw013. Review.

PMID:
27005468
10.

A Comparison of LC-MS/MS and a Fully Integrated Autosampler/Solid-Phase Extraction System for the Analysis of Protein Binding Samples.

Amaral A, Saran C, Amin J, Hatsis P.

J Biomol Screen. 2016 Jul;21(6):620-5. doi: 10.1177/1087057116630706. Epub 2016 Feb 22.

PMID:
26903406
11.

A novel LC-MS/MS assay for heparan sulfate screening in the cerebrospinal fluid of mucopolysaccharidosis IIIA patients.

Naimy H, Powell KD, Moriarity JR, Wu J, McCauley TG, Haslett PA, Barbier AJ, Qiu Y.

Bioanalysis. 2016 Feb;8(4):285-95. doi: 10.4155/bio.15.243. Epub 2016 Feb 5.

PMID:
26847798
12.

Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer.

Clark O, Yen K, Mellinghoff IK.

Clin Cancer Res. 2016 Apr 15;22(8):1837-42. doi: 10.1158/1078-0432.CCR-13-1333. Epub 2016 Jan 27.

PMID:
26819452
13.

Idh1 mutations contribute to the development of T-cell malignancies in genetically engineered mice.

Hao Z, Cairns RA, Inoue S, Li WY, Sheng Y, Lemonnier F, Wakeham A, Snow BE, Dominguez-Brauer C, Ye J, Larsen DM, Straley KS, Tobin ER, Narayanaswamy R, Gaulard P, Mak TW.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1387-92. doi: 10.1073/pnas.1525354113. Epub 2016 Jan 19.

14.

Integration of 2-hydroxyglutarate-proton magnetic resonance spectroscopy into clinical practice for disease monitoring in isocitrate dehydrogenase-mutant glioma.

de la Fuente MI, Young RJ, Rubel J, Rosenblum M, Tisnado J, Briggs S, Arevalo-Perez J, Cross JR, Campos C, Straley K, Zhu D, Dong C, Thomas A, Omuro AA, Nolan CP, Pentsova E, Kaley TJ, Oh JH, Noeske R, Maher E, Choi C, Gutin PH, Holodny AI, Yen K, DeAngelis LM, Mellinghoff IK, Thakur SB.

Neuro Oncol. 2016 Feb;18(2):283-90. doi: 10.1093/neuonc/nov307. Epub 2015 Dec 20.

PMID:
26691210
15.

Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells.

Garate Z, Quintana-Bustamante O, Crane AM, Olivier E, Poirot L, Galetto R, Kosinski P, Hill C, Kung C, Agirre X, Orman I, Cerrato L, Alberquilla O, Rodriguez-Fornes F, Fusaki N, Garcia-Sanchez F, Maia TM, Ribeiro ML, Sevilla J, Prosper F, Jin S, Mountford J, Guenechea G, Gouble A, Bueren JA, Davis BR, Segovia JC.

Stem Cell Reports. 2015 Dec 8;5(6):1053-66. doi: 10.1016/j.stemcr.2015.10.002. Epub 2015 Nov 5.

16.

Quantitative profiling of tissue drug distribution by MS imaging.

Pirman D.

Bioanalysis. 2015;7(20):2649-56. doi: 10.4155/bio.15.179. Epub 2015 Oct 23.

PMID:
26495807
17.

ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis.

Jin S, Chen J, Chen L, Histen G, Lin Z, Gross S, Hixon J, Chen Y, Kung C, Chen Y, Fu Y, Lu Y, Lin H, Cai X, Yang H, Cairns RA, Dorsch M, Su SM, Biller S, Mak TW, Cang Y.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9088-93. doi: 10.1073/pnas.1510757112. Epub 2015 Jul 6.

18.

ESKAPEing the labyrinth of antibacterial discovery.

Tommasi R, Brown DG, Walkup GK, Manchester JI, Miller AA.

Nat Rev Drug Discov. 2015 Aug;14(8):529-42. doi: 10.1038/nrd4572. Epub 2015 Jul 3. Erratum in: Nat Rev Drug Discov. 2015 Sep;14(9):662.

PMID:
26139286
19.

Characteristics, clinical outcome, and prognostic significance of IDH mutations in AML.

DiNardo CD, Ravandi F, Agresta S, Konopleva M, Takahashi K, Kadia T, Routbort M, Patel KP, Mark Brandt, Pierce S, Garcia-Manero G, Cortes J, Kantarjian H.

Am J Hematol. 2015 Aug;90(8):732-6. doi: 10.1002/ajh.24072.

PMID:
26016821
20.

Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization.

Jha AK, Huang SC, Sergushichev A, Lampropoulou V, Ivanova Y, Loginicheva E, Chmielewski K, Stewart KM, Ashall J, Everts B, Pearce EJ, Driggers EM, Artyomov MN.

Immunity. 2015 Mar 17;42(3):419-30. doi: 10.1016/j.immuni.2015.02.005.

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