Aging and disease: connections to sirtuins.
Aging Cell. 2010.
PMID: 20409078
Review.
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Aging and disease: connections to sirtuins.
Donmez G, Guarente L.
Donmez G, et al.
Aging Cell. 2010 Apr;9(2):285-90. doi: 10.1111/j.1474-9726.2010.00548.x.
Aging Cell. 2010.
PMID: 20409078
Free article.
Review.
The sirtuins are highly conserved NAD-dependent deacetylases that were shown to regulate lifespan in lower organisms and affect diseases of aging in mammals, such as diabetes, cancer, and inflammation. ...Here we discuss several diseases of aging for which SIRT1 has been r …
The sirtuins are highly conserved NAD-dependent deacetylases that were shown to regulate lifespan in lower organisms and affect disea …
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Longevity-Promoting Pathways and Transcription Factors Respond to and Control Extracellular Matrix Dynamics During Aging and Disease.
Vidović T, Ewald CY.
Vidović T, et al.
Front Aging. 2022 Jul 7;3:935220. doi: 10.3389/fragi.2022.935220. eCollection 2022.
Front Aging. 2022.
PMID: 35874275
Free PMC article.
Review.
Longevity-promoting signaling pathways slow or prevent age-related diseases. In particular, we focus on the mTOR signaling pathway, sirtuins, and canonical longevity-promoting transcription factors, such as FOXO, NF-kappaB, and Nrf2. ...Therefore, to successfully treat age …
Longevity-promoting signaling pathways slow or prevent age-related diseases. In particular, we focus on the mTOR signaling pathway, sirtu …
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Associations among Metabolism, Circadian Rhythm and Age-Associated Diseases.
Cao Y, Wang RH.
Cao Y, et al.
Aging Dis. 2017 May 2;8(3):314-333. doi: 10.14336/AD.2016.1101. eCollection 2017 May.
Aging Dis. 2017.
PMID: 28580187
Free PMC article.
Review.
Accumulating epidemiological studies have implicated a strong link between age associated metabolic diseases and cancer, though direct and irrefutable evidence is missing. In this review, we discuss the connection between Warburg effects and tumorigenesis, as well as adapt …
Accumulating epidemiological studies have implicated a strong link between age associated metabolic diseases and cancer, though direct and i …
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