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Results: 1 to 20 of 71

1.

A Systematic Assessment of Mitochondrial Function Identified Novel Signatures for Drug-Induced Mitochondrial Disruption in Cells.

Li N, Oquendo E, Capaldi RA, Robinson JP, He YD, Hamadeh HK, Afshari CA, Lightfoot-Dunn R, Narayanan PK.

Toxicol Sci. 2014 Aug 27. pii: kfu176. [Epub ahead of print]

PMID:
25163676
[PubMed - as supplied by publisher]
2.

Common handling procedures conducted in preclinical safety studies result in minimal hepatic gene expression changes in sprague-dawley rats.

He YD, Karbowski CM, Werner J, Everds N, Di Palma C, Chen Y, Higgins-Garn M, Tran S, Afshari CA, Hamadeh HK.

PLoS One. 2014 Feb 14;9(2):e88750. doi: 10.1371/journal.pone.0088750. eCollection 2014.

PMID:
24551150
[PubMed - in process]
Free PMC Article
3.

A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.

Morgan RE, van Staden CJ, Chen Y, Kalyanaraman N, Kalanzi J, Dunn RT 2nd, Afshari CA, Hamadeh HK.

Toxicol Sci. 2013 Nov;136(1):216-41. doi: 10.1093/toxsci/kft176. Epub 2013 Aug 16.

PMID:
23956101
[PubMed - indexed for MEDLINE]
4.

A novel statistical algorithm for gene expression analysis helps differentiate pregnane X receptor-dependent and independent mechanisms of toxicity.

Mongan MA, Dunn RT, Vonderfecht S, Everds N, Chen G, Su C, Higgins-Garn M, Chen Y, Afshari CA, Williamson TL, Carlock L, Dipalma C, Moss S, Bussiere J, Qualls C, He YD, Hamadeh HK.

PLoS One. 2010 Dec 21;5(12):e15595. doi: 10.1371/journal.pone.0015595.

PMID:
21203578
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

The evolution of bioinformatics in toxicology: advancing toxicogenomics.

Afshari CA, Hamadeh HK, Bushel PR.

Toxicol Sci. 2011 Mar;120 Suppl 1:S225-37. doi: 10.1093/toxsci/kfq373. Epub 2010 Dec 22. Review.

PMID:
21177775
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.

Morgan RE, Trauner M, van Staden CJ, Lee PH, Ramachandran B, Eschenberg M, Afshari CA, Qualls CW Jr, Lightfoot-Dunn R, Hamadeh HK.

Toxicol Sci. 2010 Dec;118(2):485-500. doi: 10.1093/toxsci/kfq269. Epub 2010 Sep 9.

PMID:
20829430
[PubMed - indexed for MEDLINE]
Free Article
7.

Application of genomics for identification of systemic toxicity triggers associated with VEGF-R inhibitors.

Hamadeh HK, Todd M, Healy L, Meyer JT, Kwok AM, Higgins M, Afshari CA.

Chem Res Toxicol. 2010 Jun 21;23(6):1025-33. doi: 10.1021/tx1000333.

PMID:
20521778
[PubMed - indexed for MEDLINE]
8.

Forum Series: the "Vision" for Toxicity Testing in the 21st Century: promises and conundrums.

Holsapple MP, Afshari CA, Lehman-McKeeman LD.

Toxicol Sci. 2009 Feb;107(2):307-8. doi: 10.1093/toxsci/kfn258. Epub 2008 Dec 9. No abstract available.

PMID:
19066395
[PubMed - indexed for MEDLINE]
Free Article
9.

Insight into redox-regulated gene networks in vascular cells.

Johnson CD, Balagurunathan Y, Dougherty ER, Afshari CA, He Q, Ramos KS.

Bioinformation. 2007 Apr 10;1(10):379-83.

PMID:
17597926
[PubMed]
Free PMC Article
10.

Use of a mixed tissue RNA design for performance assessments on multiple microarray formats.

Thompson KL, Rosenzweig BA, Pine PS, Retief J, Turpaz Y, Afshari CA, Hamadeh HK, Damore MA, Boedigheimer M, Blomme E, Ciurlionis R, Waring JF, Fuscoe JC, Paules R, Tucker CJ, Fare T, Coffey EM, He Y, Collins PJ, Jarnagin K, Fujimoto S, Ganter B, Kiser G, Kaysser-Kranich T, Sina J, Sistare FD.

Nucleic Acids Res. 2005 Dec 23;33(22):e187.

PMID:
16377776
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Adaptation of estrogen-regulated genes in long-term estradiol deprived MCF-7 breast cancer cells.

Santen RJ, Lobenhofer EK, Afshari CA, Bao Y, Song RX.

Breast Cancer Res Treat. 2005 Dec;94(3):213-23.

PMID:
16258703
[PubMed - indexed for MEDLINE]
12.

Estrogen-induced changes in IGF-I, Myb family and MAP kinase pathway genes in human uterine leiomyoma and normal uterine smooth muscle cell lines.

Swartz CD, Afshari CA, Yu L, Hall KE, Dixon D.

Mol Hum Reprod. 2005 Jun;11(6):441-50. Epub 2005 May 6.

PMID:
15879465
[PubMed - indexed for MEDLINE]
Free Article
13.

Prediction of nephrotoxicant action and identification of candidate toxicity-related biomarkers.

Thukral SK, Nordone PJ, Hu R, Sullivan L, Galambos E, Fitzpatrick VD, Healy L, Bass MB, Cosenza ME, Afshari CA.

Toxicol Pathol. 2005;33(3):343-55.

PMID:
15805072
[PubMed - indexed for MEDLINE]
Free Article
14.

Integrating phenotypic and expression profiles to map arsenic-response networks.

Haugen AC, Kelley R, Collins JB, Tucker CJ, Deng C, Afshari CA, Brown JM, Ideker T, Van Houten B.

Genome Biol. 2004;5(12):R95. Epub 2004 Nov 29.

PMID:
15575969
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Exploration of low-dose estrogen effects: identification of No Observed Transcriptional Effect Level (NOTEL).

Lobenhofer EK, Cui X, Bennett L, Cable PL, Merrick BA, Churchill GA, Afshari CA.

Toxicol Pathol. 2004 Jul-Aug;32(4):482-92.

PMID:
15223774
[PubMed - indexed for MEDLINE]
Free Article
16.

Integration of clinical and gene expression endpoints to explore furan-mediated hepatotoxicity.

Hamadeh HK, Jayadev S, Gaillard ET, Huang Q, Stoll R, Blanchard K, Chou J, Tucker CJ, Collins J, Maronpot R, Bushel P, Afshari CA.

Mutat Res. 2004 May 18;549(1-2):169-83.

PMID:
15120969
[PubMed - indexed for MEDLINE]
17.

Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition.

Jansen MS, Nagel SC, Miranda PJ, Lobenhofer EK, Afshari CA, McDonnell DP.

Proc Natl Acad Sci U S A. 2004 May 4;101(18):7199-204. Epub 2004 Apr 21.

PMID:
15103026
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program.

Crawford YG, Gauthier ML, Joubel A, Mantei K, Kozakiewicz K, Afshari CA, Tlsty TD.

Cancer Cell. 2004 Mar;5(3):263-73.

PMID:
15050918
[PubMed - indexed for MEDLINE]
Free Article
19.

Identification of platform-independent gene expression markers of cisplatin nephrotoxicity.

Thompson KL, Afshari CA, Amin RP, Bertram TA, Car B, Cunningham M, Kind C, Kramer JA, Lawton M, Mirsky M, Naciff JM, Oreffo V, Pine PS, Sistare FD.

Environ Health Perspect. 2004 Mar;112(4):488-94.

PMID:
15033599
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Identification of putative gene based markers of renal toxicity.

Amin RP, Vickers AE, Sistare F, Thompson KL, Roman RJ, Lawton M, Kramer J, Hamadeh HK, Collins J, Grissom S, Bennett L, Tucker CJ, Wild S, Kind C, Oreffo V, Davis JW 2nd, Curtiss S, Naciff JM, Cunningham M, Tennant R, Stevens J, Car B, Bertram TA, Afshari CA.

Environ Health Perspect. 2004 Mar;112(4):465-79.

PMID:
15033597
[PubMed - indexed for MEDLINE]
Free PMC Article

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