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Items: 1 to 20 of 105

1.

Pre-existence and Persistence of Resistant Minority Hepatitis C Virus Variants in Genotype 1-Infected Patients Treated With Simeprevir/Peginterferon/Ribavirin.

Fevery B, Thys K, Van Eygen V, Verbinnen T, Van Rossem E, Buelens A, Aerssens J, Witek J, Picchio G, De Meyer S, Lenz O.

Open Forum Infect Dis. 2016 Mar 14;3(2):ofw052. doi: 10.1093/ofid/ofw052. eCollection 2016 Mar.

2.

A Follow-Up of the Multicenter Collaborative Study on HIV-1 Drug Resistance and Tropism Testing Using 454 Ultra Deep Pyrosequencing.

St John EP, Simen BB, Turenchalk GS, Braverman MS, Abbate I, Aerssens J, Bouchez O, Gabriel C, Izopet J, Meixenberger K, Di Giallonardo F, Schlapbach R, Paredes R, Sakwa J, Schmitz-Agheguian GG, Thielen A, Victor M, Metzner KJ, Däumer MP; 454 HIV-1 Alpha Study Group.

PLoS One. 2016 Jan 12;11(1):e0146687. doi: 10.1371/journal.pone.0146687. eCollection 2016.

3.

QQ-SNV: single nucleotide variant detection at low frequency by comparing the quality quantiles.

Van der Borght K, Thys K, Wetzels Y, Clement L, Verbist B, Reumers J, van Vlijmen H, Aerssens J.

BMC Bioinformatics. 2015 Nov 10;16:379. doi: 10.1186/s12859-015-0812-9.

4.

Deep sequencing analysis of HIV-1 reverse transcriptase at baseline and time of failure in patients receiving rilpivirine in the phase III studies ECHO and THRIVE.

Van Eygen V, Thys K, Van Hove C, Rimsky LT, De Meyer S, Aerssens J, Picchio G, Vingerhoets J.

J Med Virol. 2016 May;88(5):798-806. doi: 10.1002/jmv.24395. Epub 2015 Oct 5.

PMID:
26412111
5.

High MIG (CXCL9) plasma levels favours response to peginterferon and ribavirin in HCV-infected patients regardless of DPP4 activity.

Johansson S, Talloen W, Tuefferd M, Darling J, Fanning G, Fried MW, Aerssens J.

Liver Int. 2016 Mar;36(3):344-52. doi: 10.1111/liv.12932. Epub 2015 Sep 6.

PMID:
26344576
6.

Translation of disease associated gene signatures across tissues.

Kasim A, Shkedy Z, Lin D, Van Sanden S, Abrahantes JC, Göhlmann HW, Bijnens L, Yekutieli D, Camilleri M, Aerssens J, Talloen W.

Int J Data Min Bioinform. 2015;11(3):301-13.

PMID:
26333264
7.

Plasma levels of growth-related oncogene (CXCL1-3) associated with fibrosis and platelet counts in HCV-infected patients.

Johansson S, Talloen W, Tuefferd M, Darling JM, Scholliers A, Fanning G, Fried MW, Aerssens J.

Aliment Pharmacol Ther. 2015 Nov;42(9):1111-21. doi: 10.1111/apt.13389. Epub 2015 Aug 28.

PMID:
26314558
8.

High-throughput analysis of human cytomegalovirus genome diversity highlights the widespread occurrence of gene-disrupting mutations and pervasive recombination.

Sijmons S, Thys K, Mbong Ngwese M, Van Damme E, Dvorak J, Van Loock M, Li G, Tachezy R, Busson L, Aerssens J, Van Ranst M, Maes P.

J Virol. 2015 May 13. pii: JVI.00578-15. [Epub ahead of print]

9.

Performance assessment of the Illumina massively parallel sequencing platform for deep sequencing analysis of viral minority variants.

Thys K, Verhasselt P, Reumers J, Verbist BM, Maes B, Aerssens J.

J Virol Methods. 2015 Sep 1;221:29-38. doi: 10.1016/j.jviromet.2015.04.022. Epub 2015 Apr 25.

PMID:
25917877
10.

Patient-centered drug discovery as the means to improved R&D productivity.

Raoof AA, Aerssens J.

Drug Discov Today. 2015 Sep;20(9):1044-8. doi: 10.1016/j.drudis.2015.04.002. Epub 2015 Apr 20. No abstract available.

PMID:
25908579
11.

ViVaMBC: estimating viral sequence variation in complex populations from illumina deep-sequencing data using model-based clustering.

Verbist B, Clement L, Reumers J, Thys K, Vapirev A, Talloen W, Wetzels Y, Meys J, Aerssens J, Bijnens L, Thas O.

BMC Bioinformatics. 2015 Feb 22;16:59. doi: 10.1186/s12859-015-0458-7.

12.

VirVarSeq: a low-frequency virus variant detection pipeline for Illumina sequencing using adaptive base-calling accuracy filtering.

Verbist BM, Thys K, Reumers J, Wetzels Y, Van der Borght K, Talloen W, Aerssens J, Clement L, Thas O.

Bioinformatics. 2015 Jan 1;31(1):94-101. doi: 10.1093/bioinformatics/btu587. Epub 2014 Aug 31.

13.

Deep-sequencing analysis of the gene encoding the hepatitis C virus nonstructural 3-4A protease confirms a low prevalence of telaprevir-resistant variants at baseline and the end of the REALIZE study.

Dierynck I, Thys K, Ghys A, Sullivan JC, Kieffer TL, Aerssens J, Picchio G, De Meyer S.

J Infect Dis. 2014 Dec 15;210(12):1871-80. doi: 10.1093/infdis/jiu340. Epub 2014 Jun 18.

14.

A method enabling high-throughput sequencing of human cytomegalovirus complete genomes from clinical isolates.

Sijmons S, Thys K, Corthout M, Van Damme E, Van Loock M, Bollen S, Baguet S, Aerssens J, Van Ranst M, Maes P.

PLoS One. 2014 Apr 22;9(4):e95501. doi: 10.1371/journal.pone.0095501. eCollection 2014.

15.

An international multicenter study on HIV-1 drug resistance testing by 454 ultra-deep pyrosequencing.

Simen BB, Braverman MS, Abbate I, Aerssens J, Bidet Y, Bouchez O, Gabriel C, Izopet J, Kessler HH, Stelzl E, Di Giallonardo F, Schlapbach R, Radonic A, Paredes R, Recordon-Pinson P, Sakwa J, St John EP, Schmitz-Agheguian GG, Metzner KJ, Däumer MP; 454 HIV Alphastudy Group.

J Virol Methods. 2014 Aug;204:31-7. doi: 10.1016/j.jviromet.2014.04.007. Epub 2014 Apr 13.

PMID:
24731928
16.

Efficiency of whole genome amplification of single circulating tumor cells enriched by CellSearch and sorted by FACS.

Swennenhuis JF, Reumers J, Thys K, Aerssens J, Terstappen LW.

Genome Med. 2013 Nov 29;5(11):106. doi: 10.1186/gm510. eCollection 2013.

17.

IgG variable region and VH CDR3 diversity in unimmunized mice analyzed by massively parallel sequencing.

Lu J, Panavas T, Thys K, Aerssens J, Naso M, Fisher J, Rycyzyn M, Sweet RW.

Mol Immunol. 2014 Feb;57(2):274-83. doi: 10.1016/j.molimm.2013.09.008. Epub 2013 Nov 8.

PMID:
24211535
18.

Limited impact of IL28B genotype on response rates in telaprevir-treated patients with prior treatment failure.

Pol S, Aerssens J, Zeuzem S, Andreone P, Lawitz EJ, Roberts S, Younossi Z, Foster GR, Focaccia R, Horban A, Pockros PJ, Van Heeswijk RP, De Meyer S, Luo D, Botfield M, Beumont M, Picchio G.

J Hepatol. 2013 May;58(5):883-9. doi: 10.1016/j.jhep.2012.12.023. Epub 2013 Jan 12.

PMID:
23321318
19.

Inactivation of the constitutively active ghrelin receptor attenuates limbic seizure activity in rodents.

Portelli J, Thielemans L, Ver Donck L, Loyens E, Coppens J, Aourz N, Aerssens J, Vermoesen K, Clinckers R, Schallier A, Michotte Y, Moechars D, Collingridge GL, Bortolotto ZA, Smolders I.

Neurotherapeutics. 2012 Jul;9(3):658-72. doi: 10.1007/s13311-012-0125-x.

20.

Genetic variation in human muscle strength--opportunities for therapeutic interventions?

Thomis MA, Aerssens J.

Curr Opin Pharmacol. 2012 Jun;12(3):355-62. doi: 10.1016/j.coph.2012.03.003. Epub 2012 Mar 23. Review.

PMID:
22445284
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