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Results: 1 to 20 of 68

1.

On "pathogenesis and management of postoperative ileus" (clin colon rectal surg 2009;22:47-50).

Techner LM.

Clin Colon Rectal Surg. 2010 Jun;23(2):128. doi: 10.1055/s-0030-1254301. No abstract available.

PMID:
21629631
[PubMed]
Free PMC Article
2.

Historical overview of chemical library design.

Dolle RE.

Methods Mol Biol. 2011;685:3-25. doi: 10.1007/978-1-60761-931-4_1. Review.

PMID:
20981516
[PubMed - indexed for MEDLINE]
3.

Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.

Dolle RE, Bourdonnec BL, Worm K, Morales GA, Thomas CJ, Zhang W.

J Comb Chem. 2010 Nov 8;12(6):765-806. doi: 10.1021/cc100128w. Epub 2010 Oct 5. Review. No abstract available.

PMID:
20923157
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Design and Synthesis of Imidazopyrimidine Derivatives as Potent iNOS Dimerization Inhibitors.

Chu GH, Le Bourdonnec B, Gu M, Ajello CW, Leister LK, Sellitto I, Cassel JA, Tuthill PA, O' Hare H, Dehaven RN, Dolle RE.

Open Med Chem J. 2009 Nov 18;3:8-13. doi: 10.2174/1874104500903010008.

PMID:
19966921
[PubMed]
Free PMC Article
5.

Novel sulfamoyl benzamides as selective CB(2) agonists with improved in vitro metabolic stability.

Sellitto I, Le Bourdonnec B, Worm K, Goodman A, Savolainen MA, Chu GH, Ajello CW, Saeui CT, Leister LK, Cassel JA, Dehaven RN, Labuda CJ, Koblish M, Little PJ, Brogdon BL, Smith SA, Dolle RE.

Bioorg Med Chem Lett. 2010 Jan 1;20(1):387-91. doi: 10.1016/j.bmcl.2009.10.062. Epub 2009 Oct 17.

PMID:
19919895
[PubMed - indexed for MEDLINE]
6.

Simultaneous optimization of potency, selectivity and physicochemical properties for cannabinoid CB(2) ligands.

Worm K, Dolle RE.

Curr Pharm Des. 2009;15(29):3345-66. Review.

PMID:
19860684
[PubMed - indexed for MEDLINE]
7.

High-performance liquid chromatographic enantioseparation of methanobenzazocines.

Barker WM, Worm K, Dolle RE.

J Chromatogr A. 2009 Nov 6;1216(45):7708-14. doi: 10.1016/j.chroma.2009.08.033. Epub 2009 Aug 18.

PMID:
19801151
[PubMed - indexed for MEDLINE]
8.

Novel pyridine derivatives as potent and selective CB2 cannabinoid receptor agonists.

Chu GH, Saeui CT, Worm K, Weaver DG, Goodman AJ, Broadrup RL, Cassel JA, DeHaven RN, LaBuda CJ, Koblish M, Brogdon B, Smith S, Le Bourdonnec B, Dolle RE.

Bioorg Med Chem Lett. 2009 Oct 15;19(20):5931-5. doi: 10.1016/j.bmcl.2009.08.063. Epub 2009 Aug 21.

PMID:
19736007
[PubMed - indexed for MEDLINE]
9.

Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2008.

Dolle RE, Le Bourdonnec B, Goodman AJ, Morales GA, Thomas CJ, Zhang W.

J Comb Chem. 2009 Sep-Oct;11(5):739-90. doi: 10.1021/cc9000828. Review. No abstract available.

PMID:
19715292
[PubMed - indexed for MEDLINE]
10.

Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) benzamide (ADL5747).

Le Bourdonnec B, Windh RT, Leister LK, Zhou QJ, Ajello CW, Gu M, Chu GH, Tuthill PA, Barker WM, Koblish M, Wiant DD, Graczyk TM, Belanger S, Cassel JA, Feschenko MS, Brogdon BL, Smith SA, Derelanko MJ, Kutz S, Little PJ, DeHaven RN, DeHaven-Hudkins DL, Dolle RE.

J Med Chem. 2009 Sep 24;52(18):5685-702. doi: 10.1021/jm900773n.

PMID:
19694468
[PubMed - indexed for MEDLINE]
11.

Medicinal chemistry strategies to reduce CYP2D6 inhibitory activity of lead candidates.

Le Bourdonnec B, Leister LK.

Curr Med Chem. 2009;16(24):3093-121. Review.

PMID:
19689286
[PubMed - indexed for MEDLINE]
12.

Discovery of N-(3-(morpholinomethyl)-phenyl)-amides as potent and selective CB2 agonists.

Worm K, Weaver DG, Green RC, Saeui CT, Dulay DM, Barker WM, Cassel JA, Stabley GJ, DeHaven RN, LaBuda CJ, Koblish M, Brogdon BL, Smith SA, Dolle RE.

Bioorg Med Chem Lett. 2009 Sep 1;19(17):5004-8. doi: 10.1016/j.bmcl.2009.07.057. Epub 2009 Jul 12.

PMID:
19646869
[PubMed - indexed for MEDLINE]
13.

Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208.

Dolle RE, Michaut M, Martinez-Teipel B, Seida PR, Ajello CW, Muller AL, DeHaven RN, Carroll PJ.

Bioorg Med Chem Lett. 2009 Jul 1;19(13):3647-50. doi: 10.1016/j.bmcl.2009.04.105. Epub 2009 May 3.

PMID:
19464172
[PubMed - indexed for MEDLINE]
14.

CB2 selective sulfamoyl benzamides: optimization of the amide functionality.

Goodman AJ, Ajello CW, Worm K, Le Bourdonnec B, Savolainen MA, O'Hare H, Cassel JA, Stabley GJ, Dehaven RN, Labuda CJ, Koblish M, Little PJ, Brogdon BL, Smith SA, Dolle RE.

Bioorg Med Chem Lett. 2009 Jan 15;19(2):309-13. doi: 10.1016/j.bmcl.2008.11.091. Epub 2008 Nov 27.

PMID:
19091565
[PubMed - indexed for MEDLINE]
15.

Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2007.

Dolle RE, Le Bourdonnec B, Goodman AJ, Morales GA, Thomas CJ, Zhang W.

J Comb Chem. 2008 Nov-Dec;10(6):753-802. doi: 10.1021/cc800119z. Review. No abstract available.

PMID:
18991466
[PubMed - indexed for MEDLINE]
16.

Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859).

Le Bourdonnec B, Windh RT, Ajello CW, Leister LK, Gu M, Chu GH, Tuthill PA, Barker WM, Koblish M, Wiant DD, Graczyk TM, Belanger S, Cassel JA, Feschenko MS, Brogdon BL, Smith SA, Christ DD, Derelanko MJ, Kutz S, Little PJ, DeHaven RN, DeHaven-Hudkins DL, Dolle RE.

J Med Chem. 2008 Oct 9;51(19):5893-6. doi: 10.1021/jm8008986. Epub 2008 Sep 13.

PMID:
18788723
[PubMed - indexed for MEDLINE]
17.

Use of receptor chimeras to identify small molecules with high affinity for the dynorphin A binding domain of the kappa opioid receptor.

Kumar V, Guo D, Marella M, Cassel JA, Dehaven RN, Daubert JD, Mansson E.

Bioorg Med Chem Lett. 2008 Jun 15;18(12):3667-71. doi: 10.1016/j.bmcl.2007.11.116. Epub 2007 Dec 4.

PMID:
18487043
[PubMed - indexed for MEDLINE]
18.

Sulfamoyl benzamides as novel CB2 cannabinoid receptor ligands.

Worm K, Zhou QJ, Saeui CT, Green RC, Cassel JA, Stabley GJ, DeHaven RN, Conway-James N, LaBuda CJ, Koblish M, Little PJ, Dolle RE.

Bioorg Med Chem Lett. 2008 May 1;18(9):2830-5. doi: 10.1016/j.bmcl.2008.04.006. Epub 2008 Apr 7.

PMID:
18430570
[PubMed - indexed for MEDLINE]
19.

Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opioid receptor antagonists with improved opioid receptor selectivity profiles.

Le Bourdonnec B, Barker WM, Belanger S, Wiant DD, Conway-James NC, Cassel JA, O'Neill TJ, Little PJ, DeHaven RN, DeHaven-Hudkins DL, Dolle RE.

Bioorg Med Chem Lett. 2008 Mar 15;18(6):2006-12. doi: 10.1016/j.bmcl.2008.01.106. Epub 2008 Feb 2.

PMID:
18313920
[PubMed - indexed for MEDLINE]
20.

Oxime silanes: structure/toxicity relationships.

Derelanko MJ, Rusch GM.

Drug Chem Toxicol. 2008;31(1):97-114.

PMID:
18161510
[PubMed - indexed for MEDLINE]

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