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Items: 4


Axonal transport declines with age in two distinct phases separated by a period of relative stability.

Milde S, Adalbert R, Elaman MH, Coleman MP.

Neurobiol Aging. 2015 Feb;36(2):971-81. doi: 10.1016/j.neurobiolaging.2014.09.018. Epub 2014 Sep 28.


Wld S protein requires Nmnat activity and a short N-terminal sequence to protect axons in mice.

Conforti L, Wilbrey A, Morreale G, Janeckova L, Beirowski B, Adalbert R, Mazzola F, Di Stefano M, Hartley R, Babetto E, Smith T, Gilley J, Billington RA, Genazzani AA, Ribchester RR, Magni G, Coleman M.

J Cell Biol. 2009 Feb 23;184(4):491-500. doi: 10.1083/jcb.200807175.


The slow Wallerian degeneration protein, WldS, binds directly to VCP/p97 and partially redistributes it within the nucleus.

Laser H, Conforti L, Morreale G, Mack TG, Heyer M, Haley JE, Wishart TM, Beirowski B, Walker SA, Haase G, Celik A, Adalbert R, Wagner D, Grumme D, Ribchester RR, Plomann M, Coleman MP.

Mol Biol Cell. 2006 Mar;17(3):1075-84. Epub 2005 Dec 21.


The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves.

Beirowski B, Adalbert R, Wagner D, Grumme DS, Addicks K, Ribchester RR, Coleman MP.

BMC Neurosci. 2005 Feb 1;6:6.

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