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Year Number of Results
1980 1
1981 1
1984 2
1986 3
1987 2
1988 2
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1990 5
1991 4
1992 8
1993 1
1994 5
1995 7
1996 8
1997 6
1998 10
1999 12
2000 8
2001 15
2002 13
2003 20
2004 17
2005 15
2006 32
2007 30
2008 37
2009 33
2010 34
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2012 30
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2015 33
2016 31
2017 34
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2020 24
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2023 16
2024 10

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647 results

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Page 1
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention.
Wang Z, Emmerich A, Pillon NJ, Moore T, Hemerich D, Cornelis MC, Mazzaferro E, Broos S, Ahluwalia TS, Bartz TM, Bentley AR, Bielak LF, Chong M, Chu AY, Berry D, Dorajoo R, Dueker ND, Kasbohm E, Feenstra B, Feitosa MF, Gieger C, Graff M, Hall LM, Haller T, Hartwig FP, Hillis DA, Huikari V, Heard-Costa N, Holzapfel C, Jackson AU, Johansson Å, Jørgensen AM, Kaakinen MA, Karlsson R, Kerr KF, Kim B, Koolhaas CM, Kutalik Z, Lagou V, Lind PA, Lorentzon M, Lyytikäinen LP, Mangino M, Metzendorf C, Monroe KR, Pacolet A, Pérusse L, Pool R, Richmond RC, Rivera NV, Robiou-du-Pont S, Schraut KE, Schulz CA, Stringham HM, Tanaka T, Teumer A, Turman C, van der Most PJ, Vanmunster M, van Rooij FJA, van Vliet-Ostaptchouk JV, Zhang X, Zhao JH, Zhao W, Balkhiyarova Z, Balslev-Harder MN, Baumeister SE, Beilby J, Blangero J, Boomsma DI, Brage S, Braund PS, Brody JA, Bruinenberg M, Ekelund U, Liu CT, Cole JW, Collins FS, Cupples LA, Esko T, Enroth S, Faul JD, Fernandez-Rhodes L, Fohner AE, Franco OH, Galesloot TE, Gordon SD, Grarup N, Hartman CA, Heiss G, Hui J, Illig T, Jago R, James A, Joshi PK, Jung T, Kähönen M, Kilpeläinen TO, Koh WP, Kolcic I, Kraft PP, Kuusisto J, Launer LJ, Li A, Linneberg A, Lua… See abstract for full author list ➔ Wang Z, et al. Nat Genet. 2022 Sep;54(9):1332-1344. doi: 10.1038/s41588-022-01165-1. Epub 2022 Sep 7. Nat Genet. 2022. PMID: 36071172 Free PMC article.
Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST …
Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 …
alpha-Actinin-1 promotes activity of the L-type Ca(2+) channel Ca(v) 1.2.
Turner M, Anderson DE, Bartels P, Nieves-Cintron M, Coleman AM, Henderson PB, Man KNM, Tseng PY, Yarov-Yarovoy V, Bers DM, Navedo MF, Horne MC, Ames JB, Hell JW. Turner M, et al. EMBO J. 2020 Mar 2;39(5):e102622. doi: 10.15252/embj.2019102622. Epub 2020 Jan 27. EMBO J. 2020. PMID: 31985069 Free PMC article.
We report a bi-functional mechanism that restricts Ca(V) 1.2 activity to its target sites. We solved separate NMR structures of the IQ motif (residues 1,646-1,664) bound to alpha-actinin-1 and to apo-calmodulin (apoCaM). The Ca(V) 1 …
We report a bi-functional mechanism that restricts Ca(V) 1.2 activity to its target sites. We solved separate NMR structures of the I …
alpha-actinin-3 and performance.
Yang N, Garton F, North K. Yang N, et al. Med Sport Sci. 2009;54:88-101. doi: 10.1159/000235698. Epub 2009 Aug 17. Med Sport Sci. 2009. PMID: 19696509

There is a common stop codon polymorphism R577X in the ACTN3 gene. Homozygosity for the R577X null-allele results in the absence of alpha-actinin-3 in fast muscle fibers with frequencies that vary from < 1% in Africans to approximately 18% in Caucas

…
There is a common stop codon polymorphism R577X in the ACTN3 gene. Homozygosity for the R577X null-allele results in the absence of …
Novel insight into the role of alpha-actinin-1 in rheumatoid arthritis.
Huang RY, Huang QC, Burgering BM. Huang RY, et al. Discov Med. 2014 Feb;17(92):75-80. Discov Med. 2014. PMID: 24534470 Free article. Review.
Following stimulation by pro-inflammatory cytokines, FLS cells are phenotypically changed to have the capability to proliferate abnormally. Recently we demonstrated that alpha-actinin-1 (ACTN1) gene is significantly increased in synovial tissues obtain …
Following stimulation by pro-inflammatory cytokines, FLS cells are phenotypically changed to have the capability to proliferate abnormally. …
Calcium affinity of human alpha-actinin 1.
Backman L. Backman L. PeerJ. 2015 May 7;3:e944. doi: 10.7717/peerj.944. eCollection 2015. PeerJ. 2015. PMID: 26020004 Free PMC article.
Due to alternative splicing, the human ACTN1 gene codes for three different transcripts of alpha-actinin; one isoform that is expressed only in the brain and two with a more general expression pattern. ...To investigate this further, the calcium affinities of …
Due to alternative splicing, the human ACTN1 gene codes for three different transcripts of alpha-actinin; one isoform t …
How does alpha-actinin-3 deficiency alter muscle function? Mechanistic insights into ACTN3, the 'gene for speed'.
Lee FX, Houweling PJ, North KN, Quinlan KG. Lee FX, et al. Biochim Biophys Acta. 2016 Apr;1863(4):686-93. doi: 10.1016/j.bbamcr.2016.01.013. Epub 2016 Jan 21. Biochim Biophys Acta. 2016. PMID: 26802899 Free article. Review.
An estimated 1.5 billion people worldwide are deficient in the skeletal muscle protein alpha-actinin-3 due to homozygosity for the common ACTN3 R577X polymorphism. alpha-Actinin-3 deficiency influences muscle performance in elite athletes and th …
An estimated 1.5 billion people worldwide are deficient in the skeletal muscle protein alpha-actinin-3 due to homozygos …
Fibroblast growth factor-1-inducible gene FR-17 encodes a nonmuscle alpha-actinin isoform.
Hsu DK, Guo Y, Alberts GF, Peifley KA, Winkles JA. Hsu DK, et al. J Cell Physiol. 1996 May;167(2):261-8. doi: 10.1002/(SICI)1097-4652(199605)167:2<261::AID-JCP9>3.0.CO;2-N. J Cell Physiol. 1996. PMID: 8613466
Maximal alpha-actinin mRNA expression, corresponding to an approximately nineteenfold level of induction, is present after 12 h of FGF-1 stimulation. Western blot analysis indicated that FGF-1-stimulated cells also produce an increased amount of alp …
Maximal alpha-actinin mRNA expression, corresponding to an approximately nineteenfold level of induction, is present after 12 …
Aortic Cellular Diversity and Quantitative Genome-Wide Association Study Trait Prioritization Through Single-Nuclear RNA Sequencing of the Aneurysmal Human Aorta.
Chou EL, Chaffin M, Simonson B, Pirruccello JP, Akkad AD, Nekoui M, Lino Cardenas CL, Bedi KC Jr, Nash C, Juric D, Stone JR, Isselbacher EM, Margulies KB, Klattenhoff C, Ellinor PT, Lindsay ME. Chou EL, et al. Arterioscler Thromb Vasc Biol. 2022 Nov;42(11):1355-1374. doi: 10.1161/ATVBAHA.122.317953. Epub 2022 Sep 29. Arterioscler Thromb Vasc Biol. 2022. PMID: 36172868 Free PMC article.
With unbiased methodology, we found 7 vascular smooth muscle cell and 6 fibroblast subclusters. Differentially expressed genes analysis revealed a vascular smooth muscle cell group accounting for the majority of differential gene expression. Fibroblast populations i …
With unbiased methodology, we found 7 vascular smooth muscle cell and 6 fibroblast subclusters. Differentially expressed genes analys …
Identification and Characterization of alpha-Actinin 1 of Histomonas meleagridis and Its Potential Vaccine Candidates against Histomonosis.
Liu D, Chen C, Chen Q, Wang S, Li Z, Rong J, Zhang Y, Hou Z, Tao J, Xu J. Liu D, et al. Animals (Basel). 2023 Jul 17;13(14):2330. doi: 10.3390/ani13142330. Animals (Basel). 2023. PMID: 37508107 Free PMC article.
It was then inserted into the prokaryotic expression vector pET28a(+) and induced with isopropyl-beta-D-thiogalactopyranoside. A 73 kDa recombinant protein rHmalpha-actinin 1 was obtained and purified with a Ni-NTA chromatography column. rHmalpha-actinin 1 …
It was then inserted into the prokaryotic expression vector pET28a(+) and induced with isopropyl-beta-D-thiogalactopyranoside. A 73 kDa reco …
Induction of filopodia formation by alpha-Actinin-2 via RelA with a feedforward activation loop promoting overt bone marrow metastasis of gastric cancer.
Wang C, Xie B, Yin S, Cao J, Huang J, Jin L, Du G, Zhai X, Zhang R, Li S, Cao T, Yu H, Fan X, Yang Z, Peng J, Xiao J, Lian L. Wang C, et al. J Transl Med. 2023 Jun 19;21(1):399. doi: 10.1186/s12967-023-04156-w. J Transl Med. 2023. PMID: 37337244 Free PMC article.
Mechanically, alpha-Actinin-2 was involved in filopodia formation where it promoted the Actin filament cross-linking by replacing alpha-Actinin-1 to form alpha-Actinin-2:alpha-Actinin-4 complexes in GC cells. Moreover …
Mechanically, alpha-Actinin-2 was involved in filopodia formation where it promoted the Actin filament cross-linking by replac …
647 results