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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1985 1
1987 1
1989 1
1990 1
1992 4
1993 6
1994 7
1995 2
1996 1
1997 4
1998 6
1999 3
2000 5
2001 2
2003 2
2004 8
2005 5
2006 5
2007 9
2008 3
2009 5
2010 6
2011 4
2012 6
2013 14
2014 10
2015 14
2016 13
2017 9
2018 10
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2020 8
2021 10
2022 4
2023 5
2024 1

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179 results

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Page 1
TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation.
Park HS, Song JW, Park JH, Lim BK, Moon OS, Son HY, Lee JH, Gao B, Won YS, Kwon HJ. Park HS, et al. Autophagy. 2021 Sep;17(9):2549-2564. doi: 10.1080/15548627.2020.1834711. Epub 2020 Nov 16. Autophagy. 2021. PMID: 33190588 Free PMC article.
Inhibition of MTORC1 by rapamycin induced autophagy and increased the expression levels of FAO-related genes and concomitantly attenuated lipid accumulation in PA-treated txnip-knockout (KO) hepatocytes, which was further abolished by silencing of Atg7. ...Targeting TXNIP …
Inhibition of MTORC1 by rapamycin induced autophagy and increased the expression levels of FAO-related genes and concomitantly attenu …
Autophagy drives fibroblast senescence through MTORC2 regulation.
Bernard M, Yang B, Migneault F, Turgeon J, Dieudé M, Olivier MA, Cardin GB, El-Diwany M, Underwood K, Rodier F, Hébert MJ. Bernard M, et al. Autophagy. 2020 Nov;16(11):2004-2016. doi: 10.1080/15548627.2020.1713640. Epub 2020 Jan 13. Autophagy. 2020. PMID: 31931659 Free PMC article.
Collectively, our results identify ROS as central inducers of MTORC2 activation during chronic autophagy, which in turn fuels senescence activation and myofibroblast differentiation in distinct cellular subpopulations. Abbreviations: 3-MA: 3-methyladenine; ACTA2: actin, …
Collectively, our results identify ROS as central inducers of MTORC2 activation during chronic autophagy, which in turn fuels senescence act …
SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence.
Salazar G, Cullen A, Huang J, Zhao Y, Serino A, Hilenski L, Patrushev N, Forouzandeh F, Hwang HS. Salazar G, et al. Autophagy. 2020 Jun;16(6):1092-1110. doi: 10.1080/15548627.2019.1659612. Epub 2019 Aug 28. Autophagy. 2020. PMID: 31441382 Free PMC article.
The mitochondrial regulator PPARGC1A (peroxisome proliferator activated receptor gamma, coactivator 1 alpha) regulates mitochondrial biogenesis, reducing senescence of vascular smooth muscle cells (VSMCs); however, it is unknown whether autophagy mediates PPA …
The mitochondrial regulator PPARGC1A (peroxisome proliferator activated receptor gamma, coactivator 1 alpha) regulates mitochondrial …
XBP1-mediated activation of the STING signalling pathway in macrophages contributes to liver fibrosis progression.
Wang Q, Bu Q, Liu M, Zhang R, Gu J, Li L, Zhou J, Liang Y, Su W, Liu Z, Wang M, Lian Z, Lu L, Zhou H. Wang Q, et al. JHEP Rep. 2022 Aug 18;4(11):100555. doi: 10.1016/j.jhepr.2022.100555. eCollection 2022 Nov. JHEP Rep. 2022. PMID: 36185574 Free PMC article.
BACKGROUND & AIMS: XBP1 modulates the macrophage proinflammatory response, but its function in macrophage stimulator of interferon genes (STING) activation and liver fibrosis is unknown. X-box binding protein 1 (XBP1) has been shown to promote macrophage nucleotide-bin …
BACKGROUND & AIMS: XBP1 modulates the macrophage proinflammatory response, but its function in macrophage stimulator of interferon ge …
VSMC-specific EP4 deletion exacerbates angiotensin II-induced aortic dissection by increasing vascular inflammation and blood pressure.
Xu H, Du S, Fang B, Li C, Jia X, Zheng S, Wang S, Li Q, Su W, Wang N, Zheng F, Chen L, Zhang X, Gustafsson JÅ, Guan Y. Xu H, et al. Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8457-8462. doi: 10.1073/pnas.1902119116. Epub 2019 Apr 4. Proc Natl Acad Sci U S A. 2019. PMID: 30948641 Free PMC article.
We found that chronic angiotensin II (AngII) infusion of mice with vascular smooth muscle cell (VSMC)-specific EP4 gene knockout (VSMC-EP4(-/-)) frequently developed aortic dissection (AD) with severe elastic fiber degradation and VSMC dedifferentiation. ...F …
We found that chronic angiotensin II (AngII) infusion of mice with vascular smooth muscle cell (VSMC)-specific EP4 gene …
The alpha-smooth muscle actin promoter: a useful tool to analyse autocrine and paracrine roles of mesenchymal cells in normal and diseased bowel.
Lund PK. Lund PK. Gut. 1998 Mar;42(3):320-2. doi: 10.1136/gut.42.3.320. Gut. 1998. PMID: 9577334 Free PMC article. Review.
To explore the function of IGF-I on SMC in vivo, the mouse SMC alpha-actin promotor fragment SMP8 (-1074 bp, 63 bp of 5'UT and 2.5 kb of intron 1) was cloned upstream of rat IGF-I cDNA, and the fusion gene microinjected into fertilized eggs of the FVB- …
To explore the function of IGF-I on SMC in vivo, the mouse SMC alpha-actin promotor fragment SMP8 (-1074 bp, 63 bp of 5'UT and …
Adenovirus-Mediated Overexpression of Septin 2 Attenuates alpha-Smooth Muscle Actin Expression and Adventitial Myofibroblast Migration Induced by Angiotensin II.
Guo SJ, Zhang P, Wu LY, Zhang GN, Chen WD, Gao PJ. Guo SJ, et al. J Vasc Res. 2016;53(5-6):309-316. doi: 10.1159/000452413. Epub 2016 Dec 15. J Vasc Res. 2016. PMID: 27974709
The decreased level of septin 2 and the increased expression of alpha-smooth muscle actin (alpha-SMA), a marker of MFs, were readily observed in Ang II-stimulated MF differentiation. After gene transfer of septin 2, the expr …
The decreased level of septin 2 and the increased expression of alpha-smooth muscle actin (alpha-S …
Autophagy activates EGR1 via MAPK/ERK to induce FGF2 in renal tubular cells for fibroblast activation and fibrosis during maladaptive kidney repair.
Livingston MJ, Zhang M, Kwon SH, Chen JK, Li H, Manicassamy S, Dong Z. Livingston MJ, et al. Autophagy. 2024 May;20(5):1032-1053. doi: 10.1080/15548627.2023.2281156. Epub 2023 Nov 18. Autophagy. 2024. PMID: 37978868
ChIP assay detected an increased binding of EGR1 to the Fgf2 gene promoter in TGFB1-treated tubular cells. Both Fgf2 and Egr1 transcription was inhibited by FGF2 neutralizing antibody, suggesting a positive feedback for EGR1-mediated FGF2 autoregulation. ...FGF2 is then se …
ChIP assay detected an increased binding of EGR1 to the Fgf2 gene promoter in TGFB1-treated tubular cells. Both Fgf2 and Egr1 transcr …
Phenotype-dependent expression of alpha-smooth muscle actin in visceral smooth muscle cells.
Saga H, Kimura K, Hayashi K, Gotow T, Uchiyama Y, Momiyama T, Tadokoro S, Kawashima N, Jimbou A, Sobue K. Saga H, et al. Exp Cell Res. 1999 Feb 25;247(1):279-92. doi: 10.1006/excr.1998.4339. Exp Cell Res. 1999. PMID: 10047470
Alpha-Smooth muscle actin is one of the molecular markers for a phenotype of vascular smooth muscle cells, because the actin is a major isoform expressed in vascular smooth muscle cells and its expression is upregulat …
Alpha-Smooth muscle actin is one of the molecular markers for a phenotype of vascular smooth muscle …
NADPH oxidase 4 mediates TGF-beta-induced smooth muscle alpha-actin via p38MAPK and serum response factor.
Martin-Garrido A, Brown DI, Lyle AN, Dikalova A, Seidel-Rogol B, Lassègue B, San Martín A, Griendling KK. Martin-Garrido A, et al. Free Radic Biol Med. 2011 Jan 15;50(2):354-62. doi: 10.1016/j.freeradbiomed.2010.11.007. Epub 2010 Nov 11. Free Radic Biol Med. 2011. PMID: 21074607 Free PMC article.
NADPH oxidase 4 (Nox4) is critical for maintenance of smooth muscle gene expression; however, the underlying mechanisms are incompletely characterized. Using smooth muscle alpha-actin (SMA) as a prototypical smooth muscle …
NADPH oxidase 4 (Nox4) is critical for maintenance of smooth muscle gene expression; however, the underlying mechanisms …
179 results