[Effect of general anesthesia on complement. Effect of the atmosphere in the operating room on the immune response of anesthesiologists]

Ann Anesthesiol Fr. 1976;17(3):255-8.
[Article in French]

Abstract

Variations in the C3 and C4 fractions of complement were studied in 15 patients who underwent surgery with either spinal anesthesia (5 cases) or general anesthesia using nitruos oxyde and a halogen compound (10 cases). Little peroperative variation was observed. An increase in C4 was observed in all cases postoperatively. Only a slight increase in C3 was observed after spinal anesthesia. The immune response of anesthetists exposed to halothane was investigated using PHA-induced lymphocyte stimulation (normal in males, elevated in females) and lymphocyte transformation to halothane and its metabolites (no evidence of allergy was observed).

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Air Pollutants*
  • Air Pollutants, Occupational*
  • Anesthesia, General*
  • Anesthesiology*
  • Complement System Proteins*
  • Enflurane / pharmacology*
  • Female
  • Halothane / pharmacology*
  • Humans
  • Immunity / drug effects*
  • Lymphocyte Activation / drug effects
  • Male
  • Methyl Ethers / pharmacology*
  • Operating Rooms*
  • Sex Factors

Substances

  • Air Pollutants
  • Air Pollutants, Occupational
  • Methyl Ethers
  • Complement System Proteins
  • Enflurane
  • Halothane