Format

Send to:

Choose Destination
See comment in PubMed Commons below
Int J Biochem Cell Biol. 1997 Aug-Sep;29(8-9):1059-62.

Interleukin-11.

Author information

  • 1Yale University School of Medicine, Department of Internal Medicine, New Haven, CT 06520-8057, USA.

Abstract

Interleukin-11 (IL-11) is an IL-6-type cytokine that is produced by a variety of stromal cells including fibroblasts, epithelial cells and osteoblasts. It binds to a multimeric receptor complex which contains an IL-11-specific alpha subunit and a promiscuous 130 kDa beta subunit (gp130). IL-11 stimulates multiple aspects of hematopoiesis and hepatocyte production of acute phase response proteins. It also inhibits the genesis of adipocytes, activates osteoclasts, alters neural phenotype, stimulates tissue fibrosis and regulates chondrocyte, synoviocyte and B cell function. In other settings, IL-11 minimizes tissue injury. This may be the result of its ability to protect clonogenic stem cells, regulate epithelial cell proliferation, inhibit apoptosis and inhibit macrophage cytokine production. Thus, IL-11 appears to play an important role in hematopoiesis, bone metabolism and tissue remodeling and may be an important protector of mucosal surfaces.

PMID:
9416001
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk