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The following term was not found in PubMed: 8-benzylpyrido
Unknown field was ignored: [2,3-d]
Page 1
Thiazolo[3,2-a]pyrimidin-5-one derivatives as a novel class of 11beta-hydroxysteroid dehydrogenase inhibitors.
Studzińska R, Kupczyk D, Płazińska A, Kołodziejska R, Kosmalski T, Modzelewska-Banachiewicz B. Studzińska R, et al. Bioorg Chem. 2018 Dec;81:21-26. doi: 10.1016/j.bioorg.2018.07.033. Epub 2018 Aug 1. Bioorg Chem. 2018. PMID: 30086417
In this study the inhibitory activity of 29 thiazolo[3,2-a]pyrimidin-5-one derivatives on 11beta-HSD1 were investigated. Studies were carried out with pooled human liver microsomes. ...Molecular docking simulation show that the molecule of the most active com …
In this study the inhibitory activity of 29 thiazolo[3,2-a]pyrimidin-5-one derivatives on 11beta-HSD1 were investigated …
Synthesis of Chromeno[2,3-d]pyrimidin-5-one Derivatives from 1,3,5-Triazinanes via Two Different Reaction Pathways.
Wang T, Zhang B, Hu L, Sun H, Wang Y, Zhai H, Cheng B. Wang T, et al. J Org Chem. 2022 Jan 21;87(2):1348-1356. doi: 10.1021/acs.joc.1c02649. Epub 2022 Jan 11. J Org Chem. 2022. PMID: 35012316
1,3,5-Triazinanes, as a kind of versatile building block, are applied in the synthesis of chromeno[2,3-d]pyrimidin-5-one derivatives via two different reaction modes, which perfectly exhibits the powerful function of 1,3,5-triazinane as a three-atom synthon a …
1,3,5-Triazinanes, as a kind of versatile building block, are applied in the synthesis of chromeno[2,3-d]pyrimidin-5-one …
Synthesis of 5H-Chromeno[2,3-d]pyrimidin-5-one Derivatives via Microwave-Promoted Multicomponent Reaction.
Zhang B, Yang H, Wang T, Han X, Sun H, Fang L, Zhai H, Cheng B. Zhang B, et al. J Org Chem. 2021 Dec 17;86(24):18304-18311. doi: 10.1021/acs.joc.1c02434. Epub 2021 Nov 23. J Org Chem. 2021. PMID: 34813338
A microwave-promoted multicomponent reaction of 3-formylchromones, amines, and paraformaldehyde was achieved under catalyst-free and solvent-free conditions, delivering 5H-chromeno[2,3-d]pyrimidin-5-one derivatives in good to excellent yields via an unexpecte …
A microwave-promoted multicomponent reaction of 3-formylchromones, amines, and paraformaldehyde was achieved under catalyst-free and solvent …
An efficient diastereoselective synthesis of novel fused 5H-furo[2,3-d]thiazolo[3,2-a]pyrimidin-5-ones via one-pot three-component reaction.
Tabibi T, Esmaeili AA, Mague JT. Tabibi T, et al. Mol Divers. 2022 Feb;26(1):183-190. doi: 10.1007/s11030-020-10173-4. Epub 2021 Jan 3. Mol Divers. 2022. PMID: 33389558
Herein, a convenient and efficient synthesis of 7-benzoyl-6-(aryl)-6,7-dihydro-5H-furo[2,3-d]thiazolo[3,2-a]pyrimidin-5-one derivatives was achieved from the reaction of isoquinolinium N-ylides, aromatic aldehydes, and heterocyclic 1,3-dicarbonyl compounds vi …
Herein, a convenient and efficient synthesis of 7-benzoyl-6-(aryl)-6,7-dihydro-5H-furo[2,3-d]thiazolo[3,2-a]pyrimidin-5-one …
Evaluation of 5H-Thiazolo[3,2-α]pyrimidin-5-ones as Potential GluN2A PET Tracers.
He Y, Whitehead DM, Briard E, Numao S, Mu L, Schibli R, Ametamey SM, Auberson YP. He Y, et al. ChemMedChem. 2020 Dec 15;15(24):2448-2461. doi: 10.1002/cmdc.202000340. Epub 2020 Jul 3. ChemMedChem. 2020. PMID: 32544308
We describe here our efforts to develop a PET tracer for imaging GluN2A-containing NMDA receptors, based on a 5H-thiazolo[3,2-alpha]pyrimidin-5-one scaffold. The metabolic stability and overall properties could be optimized satisfactorily, although binding af …
We describe here our efforts to develop a PET tracer for imaging GluN2A-containing NMDA receptors, based on a 5H-thiazolo[3,2-alpha]pyrim …
Synthesis of indole-tethered [1,3,4]thiadiazolo and [1,3,4]oxadiazolo[3,2-a]pyrimidin-5-one hybrids as anti-pancreatic cancer agents.
Gummidi L, Kerru N, Awolade P, Raza A, Sharma AK, Singh P. Gummidi L, et al. Bioorg Med Chem Lett. 2020 Nov 15;30(22):127544. doi: 10.1016/j.bmcl.2020.127544. Epub 2020 Sep 10. Bioorg Med Chem Lett. 2020. PMID: 32920143
New indole-tethered [1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one (8a-j) and [1,3,4]oxadiazolo[3,2-a]pyrimidin-5-one hybrids (9a-e) were synthesized using [4+2] cycloaddition reactions of functionalized 1,3-diazabuta-1,3-dienes with indole-ket …
New indole-tethered [1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one (8a-j) and [1,3,4]oxadiazolo[3,2-a]pyrimidin-5 …
Visible Light Assisted Direct C3-H Arylation of Pyrido[1,2-a]pyrimidin-4-ones and Thiazolo[3,2-a]pyrimidin-5-ones.
Bhawale RT, Kshirsagar UA. Bhawale RT, et al. J Org Chem. 2023 Jul 7;88(13):9537-9542. doi: 10.1021/acs.joc.3c00780. Epub 2023 May 30. J Org Chem. 2023. PMID: 37252904
This operationally simple and direct C-H functionalization approach effectively produced biologically significant C3 arylated pyrido[1,2-a]pyrimidin-4-one and thiazolo[3,2-a]pyrimidin-5-one derivatives, including medicinally important endothelial cell dysfunc …
This operationally simple and direct C-H functionalization approach effectively produced biologically significant C3 arylated pyrido[1,2-a]p …
Efficient microwave-assisted Suzuki-Miyaura cross-coupling reaction of 3-bromo pyrazolo[1,5-a]pyrimidin-5(4H)-one: towards a new access to 3,5-diarylated 7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine derivatives.
Jismy B, Guillaumet G, Akssira M, Tikad A, Abarbri M. Jismy B, et al. RSC Adv. 2021 Jan 4;11(3):1287-1302. doi: 10.1039/d0ra07959f. eCollection 2021 Jan 4. RSC Adv. 2021. PMID: 35747396 Free PMC article.
A convenient and efficient synthetic route to C3-arylated 7-trifluoromethylpyrazolo[1,5-a]pyrimidin-5-one derivatives has been reported starting from 3-bromo-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-5-one through a Suzuki-Miyaura cross …
A convenient and efficient synthetic route to C3-arylated 7-trifluoromethylpyrazolo[1,5-a]pyrimidin-5-one derivatives h …
Crystal structures of two 6-(2-hy-droxy-benzo-yl)-5H-thia-zolo[3,2-a]pyrimidin-5-ones.
Gomes LR, Low JN, Cagide F, Borges F. Gomes LR, et al. Acta Crystallogr E Crystallogr Commun. 2015 Jun 13;71(Pt 7):766-71. doi: 10.1107/S2056989015011044. eCollection 2015 Jul 1. Acta Crystallogr E Crystallogr Commun. 2015. PMID: 26279863 Free PMC article.
The title compounds, 6-(2-hy-droxy-benz-yl)-5H-thia-zolo[3,2-a]pyrimidin-5-one, C13H8N2O3S, (1), and 6-(2-hy-droxy-benz-yl)-3-methyl-5H-thia-zolo[3,2-a]pyrimidin-5-one, C14H10N2O3S, (2), were synthesized when a chromone-3-carb-oxy-lic aci …
The title compounds, 6-(2-hy-droxy-benz-yl)-5H-thia-zolo[3,2-a]pyrimidin-5-one, C13H8N2O3S, (1), and 6-(2-hy-droxy-benz …
81 results