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Crystal structure and Hirshfeld surface analysis of ethyl 2-{[4-ethyl-5-(quinolin-8-yloxymeth-yl)-4H-1,2,4-triazol-3-yl]sulfan-yl}acetate.
Bahoussi RI, Djafri A, Chouaih A, Djafri A, Hamzaoui F. Bahoussi RI, et al. Acta Crystallogr E Crystallogr Commun. 2017 Jan 13;73(Pt 2):173-176. doi: 10.1107/S205698901700041X. eCollection 2017 Feb 1. Acta Crystallogr E Crystallogr Commun. 2017. PMID: 28217336 Free PMC article.
In the title compound, C(18)H(20)N(4)O(3)S, the 1,2,4-triazole ring is twisted with respect to the mean plane of quinoline moiety at 65.24 (4). In the crystal, mol-ecules are linked by weak C-HO and C-HN hydrogen bonds, forming the three-dimensional supra-molecular …
In the title compound, C(18)H(20)N(4)O(3)S, the 1,2,4-triazole ring is twisted with respect to the mean plane of quinoline moi …
New hybrid trifluoromethylquinolines as antiplasmodium agents.
da Silva RMRJ, Gandi MO, Mendonça JS, Carvalho AS, Coutinho JP, Aguiar ACC, Krettli AU, Boechat N. da Silva RMRJ, et al. Bioorg Med Chem. 2019 Mar 15;27(6):1002-1008. doi: 10.1016/j.bmc.2019.01.044. Epub 2019 Feb 2. Bioorg Med Chem. 2019. PMID: 30737133 Free article.
In this study, we designed and synthesized seventeen novel quinolines based on the structures of mefloquine ((2,8-bis(trifluoromethyl)quinolin-4-yl)(piperidin-2-yl)methanol) and amodiaquine (4-((7-chloroquinolin-4-yl)amino)-2-((diethylamino)methyl)phen …
In this study, we designed and synthesized seventeen novel quinolines based on the structures of mefloquine ((2,8-bis(trifluor …