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Nucleic Acids Res. 1994 Sep;22(17):3640-59.

Effect of site-specific modification on restriction endonucleases and DNA modification methyltransferases.

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  • 1California Institute of Biological Research, La Jolla 92037.

Abstract

Restriction endonucleases have site-specific interactions with DNA that can often be inhibited by site-specific DNA methylation and other site-specific DNA modifications. However, such inhibition cannot generally be predicted. The empirically acquired data on these effects are tabulated for over 320 restriction endonucleases. In addition, a table of known site-specific DNA modification methyltransferases and their specificities is presented along with EMBL database accession numbers for cloned genes.

PMID:
7937074
[PubMed - indexed for MEDLINE]
PMCID:
PMC308336
Free PMC Article
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