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J Exp Med. 1995 Nov 1;182(5):1395-401.

A naturally occurring soluble isoform of murine Fas generated by alternative splicing.

Author information

  • 1Immunobiology Section, Yale University Medical School, New Haven, Connecticut 06510, USA.

Abstract

We report a soluble isoform of mouse Fas, which is generated by alternative splicing of Fas mRNA to a newly identified exon located between exons 2 and 3 of the previously published Fas sequence. This splicing event creates a novel Fas transcript, Fas beta, with the potential to encode a truncated form of the extracellular domain, termed Fas B. In vitro, P815 mastocytoma cells transfected with Fas B become resistant to Fas ligand-induced apoptosis, and the resistance is mediated by a secreted product of the transfected cells. In vivo, Fas beta mRNA expression is correlated inversely with apoptosis among subsets of intrahepatic T lymphocytes, a cell population in which activation-induced T cell apoptosis occurs. We propose that Fas B is a new cytokine that acts physiologically to limit apoptosis induced by Fas ligand.

PMID:
7595210
[PubMed - indexed for MEDLINE]
PMCID:
PMC2192224
Free PMC Article
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