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Year Number of Results
1980 1
1983 4
1984 2
1985 1
1986 4
1987 1
1988 5
1989 4
1990 5
1991 9
1992 10
1993 9
1994 7
1995 8
1996 3
1997 6
1998 4
1999 4
2000 4
2001 2
2002 4
2003 2
2004 4
2005 4
2006 1
2008 2
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2017 1
2024 0

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116 results

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Page 1
Melatonin-analog, beta-methyl-6-chloromelatonin, supplementation in spinal cord injury.
Fee DB, Swartz KR, Scheff N, Roberts K, Gabbita P, Scheff S. Fee DB, et al. Brain Res. 2010 Jun 22;1340:81-5. doi: 10.1016/j.brainres.2010.04.047. Epub 2010 Apr 24. Brain Res. 2010. PMID: 20420812
In this work, rats underwent a moderate-to-severe contussional SCI with either placebo or beta-methyl-6-chloromelatonin, 10mg/kg or 100mg/kg supplementation. The 10mg/kg supplementation demonstrated benefit; the 100mg/kg dosage was limited by toxicity. ...
In this work, rats underwent a moderate-to-severe contussional SCI with either placebo or beta-methyl-6-chloromelatonin, 10mg/ …
The efficacy and safety of the melatonin agonist beta-methyl-6-chloromelatonin in primary insomnia: a randomized, placebo-controlled, crossover clinical trial.
Zemlan FP, Mulchahey JJ, Scharf MB, Mayleben DW, Rosenberg R, Lankford A. Zemlan FP, et al. J Clin Psychiatry. 2005 Mar;66(3):384-90. doi: 10.4088/jcp.v66n0316. J Clin Psychiatry. 2005. PMID: 15766306 Clinical Trial.
The purpose of the present study was to determine if the melatonin agonist beta-methyl-6-chloromelatonin has a direct soporific effect in subjects with primary insomnia. ...Adverse events were mild to moderate in severity and did not differ in frequency between beta …
The purpose of the present study was to determine if the melatonin agonist beta-methyl-6-chloromelatonin has a direct soporifi …
Pulse radiolysis studies of melatonin and chloromelatonin.
Roberts JE, Hu DN, Wishart JF. Roberts JE, et al. J Photochem Photobiol B. 1998 Feb;42(2):125-32. doi: 10.1016/s1011-1344(97)00132-2. J Photochem Photobiol B. 1998. PMID: 9540219
The endogenous indole melatonin and the melatonin receptor agonist 6-chloromelatonin block the proliferation of both dermal and uveal melanoma cells by mechanisms that may involve redox reactions. ...Melatonin and 6-chloromelatonin did not react with s …
The endogenous indole melatonin and the melatonin receptor agonist 6-chloromelatonin block the proliferation of both dermal an …
A single blind, placebo controlled, across groups dose escalation study of the safety, tolerability, pharmacokinetics and pharmacodynamics of the melatonin analog beta-methyl-6-chloromelatonin.
Mulchahey JJ, Goldwater DR, Zemlan FP. Mulchahey JJ, et al. Life Sci. 2004 Aug 27;75(15):1843-56. doi: 10.1016/j.lfs.2004.03.023. Life Sci. 2004. PMID: 15302228 Clinical Trial.
This study investigated the pharmacokinetics, pharmacodynamics and safety of the melatonin agonist beta-methyl-6-chloromelatonin at doses up to 100 mg in healthy volunteers. ...The incidence of all adverse events, the severity of the event or the event's relationshi …
This study investigated the pharmacokinetics, pharmacodynamics and safety of the melatonin agonist beta-methyl-6-chloromelatonin …
Human malignant melanoma cells express high-affinity receptors for melatonin: antiproliferative effects of melatonin and 6-chloromelatonin.
Ying SW, Niles LP, Crocker C. Ying SW, et al. Eur J Pharmacol. 1993 Jul 15;246(2):89-96. doi: 10.1016/0922-4106(93)90084-m. Eur J Pharmacol. 1993. PMID: 8397097
The in vitro proliferation of M-6 cells was significantly inhibited by melatonin and its analogues 6-chloromelatonin, and 2-iodomelatonin, at concentrations ranging from 10(-9) to 10(-4) M, as demonstrated by cell counts and measurements of DNA content. ...
The in vitro proliferation of M-6 cells was significantly inhibited by melatonin and its analogues 6-chloromelatonin, and 2-io …
Reproductive effects of 6-chloromelatonin implants and/or injections in male and female Syrian hamsters (Mesocricetus auratus).
Vaughan MK, Richardson BA, Petterborg LJ, Vaughan GM, Reiter RJ. Vaughan MK, et al. J Reprod Fertil. 1986 Nov;78(2):381-7. doi: 10.1530/jrf.0.0780381. J Reprod Fertil. 1986. PMID: 3100781
Adult female hamsters were injected each afternoon for 9 weeks with 2.5, 15 or 25 micrograms of melatonin or 6-chloromelatonin (CM). Each drug resulted in a significant dose-related depression in uterine, ovarian and anterior pituitary gland weights. ...Adult male h …
Adult female hamsters were injected each afternoon for 9 weeks with 2.5, 15 or 25 micrograms of melatonin or 6-chloromelatonin …
Pharmacology and function of melatonin receptors.
Dubocovich ML. Dubocovich ML. FASEB J. 1988 Sep;2(12):2765-73. doi: 10.1096/fasebj.2.12.2842214. FASEB J. 1988. PMID: 2842214 Review.
., chicken brain) that possess the pharmacological characteristics of the retinal melatonin receptor site (order of affinities: 2-iodomelatonin greater than 6-chloromelatonin greater than or equal to melatonin greater than or equal to 6,7-di-chloro-2-methylmelatonin …
., chicken brain) that possess the pharmacological characteristics of the retinal melatonin receptor site (order of affinities: 2-iodomelato …
Agomelatine, a melatonin agonist with antidepressant properties.
Dubovsky SL, Warren C. Dubovsky SL, et al. Expert Opin Investig Drugs. 2009 Oct;18(10):1533-40. doi: 10.1517/13543780903292634. Expert Opin Investig Drugs. 2009. PMID: 19758108 Review.
Agomelatine (beta-methyl-6-chloromelatonin), which is structurally homologous to melatonin, is a potent agonist of melatonin MT1 and MT2 receptors as well as an antagonist of serotonin 5-HT(2C) receptors. ...
Agomelatine (beta-methyl-6-chloromelatonin), which is structurally homologous to melatonin, is a potent agonist of melatonin M …
Melatonergic drugs for therapeutic use in insomnia and sleep disturbances of mood disorders.
Srinivasan V, Zakaria R, Othaman Z, Brzezinski A, Prasad A, Brown GM. Srinivasan V, et al. CNS Neurol Disord Drug Targets. 2012 Mar;11(2):180-9. doi: 10.2174/187152712800269740. CNS Neurol Disord Drug Targets. 2012. PMID: 22483286 Review.
Other antidepressants depressants that are in clinical use today do not improve sleep. There are other melatonergic drugs like tasimelteon, 6-chloromelatonin. But ramelteon and agomelatine deserve special attention for treatment of insomnia and sleep disturbances as …
Other antidepressants depressants that are in clinical use today do not improve sleep. There are other melatonergic drugs like tasimelteon, …
Melatonin receptor-mediated stimulation of phosphoinositide breakdown in chick brain slices.
Popova JS, Dubocovich ML. Popova JS, et al. J Neurochem. 1995 Jan;64(1):130-8. doi: 10.1046/j.1471-4159.1995.64010130.x. J Neurochem. 1995. PMID: 7798906
The phosphoinositide response elicited by 6-chloromelatonin (10 microM) was dependent on the presence of extracellular calcium. ...The competitive melatonin receptor antagonist luzindole (10-100 microM) inhibited in a concentration-dependent manner the IP1 accumulat …
The phosphoinositide response elicited by 6-chloromelatonin (10 microM) was dependent on the presence of extracellular calcium …
116 results