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The following term was not found in PubMed: 5-nitrofuran-2-carbonyl
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Synthesis and anticonvulsant activity of 7-alkoxyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines.
Xie ZF, Chai KY, Piao HR, Kwak KC, Quan ZS. Xie ZF, et al. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4803-5. doi: 10.1016/j.bmcl.2005.07.051. Bioorg Med Chem Lett. 2005. PMID: 16139502
A series of 7-alkoxyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline derivatives was synthesized using 6-hydroxy-3,4-dihydro-1H-quinolin-2-one as a starting material. ...MES and scMet tests show that 7-(4-fluorobenzyloxy …
A series of 7-alkoxyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline derivatives was synthesized using 6-hydroxy-3,4
Effects of the monoamine stabilizer, (-)-OSU6162, on cocaine-induced locomotion and conditioned place preference in mice.
Asth L, Iglesias LP, Briânis RC, Marçal AP, Soares NP, Aguiar DC, Moreira FA. Asth L, et al. Naunyn Schmiedebergs Arch Pharmacol. 2021 Jun;394(6):1143-1152. doi: 10.1007/s00210-021-02053-x. Epub 2021 Jan 20. Naunyn Schmiedebergs Arch Pharmacol. 2021. PMID: 33471153
Here, we tested the hypothesis that the monoamine stabilizers, (-)-OSU6162 ((3S)-3-(3-methylsulfonylphenyl)-1-propylpiperidine) and aripiprazole (7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin- …
Here, we tested the hypothesis that the monoamine stabilizers, (-)-OSU6162 ((3S)-3-(3-methylsulfonylphenyl)-1-propylpiperidine …
Creating novel activated factor XI inhibitors through fragment based lead generation and structure aided drug design.
Fjellström O, Akkaya S, Beisel HG, Eriksson PO, Erixon K, Gustafsson D, Jurva U, Kang D, Karis D, Knecht W, Nerme V, Nilsson I, Olsson T, Redzic A, Roth R, Sandmark J, Tigerström A, Öster L. Fjellström O, et al. PLoS One. 2015 Jan 28;10(1):e0113705. doi: 10.1371/journal.pone.0113705. eCollection 2015. PLoS One. 2015. PMID: 25629509 Free PMC article.
A virtual screen, based on docking experiments, was performed to generate a FXIa targeted fragment library for an NMR screen that resulted in the identification of fragments binding in the FXIa S1 binding pocket. The neutral 6-chloro-3,4-dihydro-1H
A virtual screen, based on docking experiments, was performed to generate a FXIa targeted fragment library for an NMR screen that resulted i …
Focal adhesion kinase regulates collagen I-induced airway smooth muscle phenotype switching.
Dekkers BG, Spanjer AI, van der Schuyt RD, Kuik WJ, Zaagsma J, Meurs H. Dekkers BG, et al. J Pharmacol Exp Ther. 2013 Jul;346(1):86-95. doi: 10.1124/jpet.113.203042. Epub 2013 Apr 16. J Pharmacol Exp Ther. 2013. PMID: 23591997
Similarly, the specific pharmacologic FAK inhibitor PF-573228 [6-((4-((3-(methanesulfonyl)benzyl)amino)-5-trifluoromethylpyrimidin-2-yl) amino)-3,4-dihydro-1H-quinolin-2-one] as well as specific inhibitors of p38 mito …
Similarly, the specific pharmacologic FAK inhibitor PF-573228 [6-((4-((3-(methanesulfonyl)benzyl)amino)-5-trifluoromethylpyrim …
Radical ring closures of 4-isocyanato carbon-centered radicals.
Minin PL, Walton JC. Minin PL, et al. J Org Chem. 2003 Apr 4;68(7):2960-3. doi: 10.1021/jo034002o. J Org Chem. 2003. PMID: 12662077
The 2-(2-isocyanatophenyl)ethyl radical was generated from the corresponding bromide with tributyltin and tris(trimethylsilyl)silyl radicals and shown to ring close in the 6-endo-mode to afford 3,4-dihydro-1H-quinolin-2-one
The 2-(2-isocyanatophenyl)ethyl radical was generated from the corresponding bromide with tributyltin and tris(trimethylsilyl)silyl radicals …