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The following term was not found in PubMed: 1H-imidazol-5-ylmethyl
Page 1
Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases.
Bioorg Med Chem. 2015 Jul 1;23(13):3013-32. doi: 10.1016/j.bmc.2015.05.005. Epub 2015 May 13.
Bioorg Med Chem. 2015.
PMID: 26026769
The 7-aryl-1,6-naphthyridin-5-ones were methylated at 1-N and reduced to 7-aryl-1-methyl-1,2,3,4-tetrahydro-1,6-naphthyridin-5-ones. ...One compound (7-(4-bromophenyl)-1-methyl-1,2,3,4-tetrahydro-1,6-naphthyridin-5-one) showed 70-f …
The 7-aryl-1,6-naphthyridin-5-ones were methylated at 1-N and reduced to 7-aryl-1-methyl-1,2,3,4-tetrahydro-1,6-naphthyridin-5 …
Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro.
Paine HA, Nathubhai A, Woon EC, Sunderland PT, Wood PJ, Mahon MF, Lloyd MD, Thompson AS, Haikarainen T, Narwal M, Lehtiö L, Threadgill MD.
Paine HA, et al.
Bioorg Med Chem. 2015 Sep 1;23(17):5891-908. doi: 10.1016/j.bmc.2015.06.061. Epub 2015 Jul 2.
Bioorg Med Chem. 2015.
PMID: 26189030
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