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The following term was not found in PubMed: imidazole-3-carboxylic
Unknown field was ignored: [1,2-a]
Page 1
Eszopiclone.
[No authors listed] [No authors listed] 2023 Feb 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2023 Feb 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 30000277 Free Books & Documents. Review.
Recyclization of 5-Amino- oxazoles as a Route to new Functionalized Heterocycles (Developments of V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine).
Shablykin OV, Brovarets VS, Shablykina OV. Shablykin OV, et al. Chem Rec. 2024 Feb;24(2):e202300264. doi: 10.1002/tcr.202300264. Epub 2023 Oct 26. Chem Rec. 2024. PMID: 37882374 Review.
When the nitrile group is present in 4(th) position, it is often involved in the recyclization forming alpha-aminoazoles. 5-Amino/hydrazine-1,3-oxazoles undergo recyclization both in nucleophilic (amines, hydrazine, thionating agents) and electrophilic medium ((trifluoro)acetic …
When the nitrile group is present in 4(th) position, it is often involved in the recyclization forming alpha-aminoazoles. 5-Amino/hydrazine- …
Novel (2-amino-4-arylimidazolyl)propanoic acids and pyrrolo[1,2-c]imidazoles via the domino reactions of 2-amino-4-arylimidazoles with carbonyl and methylene active compounds.
Lipson VV, Pavlovska TL, Svetlichnaya NV, Poryvai AA, Gorobets NY, Van der Eycken EV, Konovalova IS, Shiskina SV, Borisov AV, Musatov VI, Mazepa AV. Lipson VV, et al. Beilstein J Org Chem. 2019 May 6;15:1032-1045. doi: 10.3762/bjoc.15.101. eCollection 2019. Beilstein J Org Chem. 2019. PMID: 31164941 Free PMC article.
The unexpectedly uncatalyzed reaction between 2-amino-4-arylimidazoles, aromatic aldehydes and Meldrum's acid has selectively led to the corresponding Knoevenagel-Michael adducts containing a free amino group in the imidazole fragment. The adducts derived from Meldrum's …
The unexpectedly uncatalyzed reaction between 2-amino-4-arylimidazoles, aromatic aldehydes and Meldrum's acid has selectively led to …
[Studies on chemical constituents of rhizomes of Sophora tonkinensis].
Pan QM, Huang RZ, Pan YM, Wang HS, Liang D. Pan QM, et al. Zhongguo Zhong Yao Za Zhi. 2016 Jan;41(1):96-100. doi: 10.4268/cjcmm20160119. Zhongguo Zhong Yao Za Zhi. 2016. PMID: 28845648 Chinese.
Thirteen compounds were isolated from the 95% aqueous EtOH extract of the rhizomes of Sophora tonkinensis by a combination of various chromatographic techniques including column chromatography over silica gel, Sphadex LH-20, MCI, ODS, and semi-preparative HPLC.Their structures we …
Thirteen compounds were isolated from the 95% aqueous EtOH extract of the rhizomes of Sophora tonkinensis by a combination of various chroma …
Derivatization strategy for semi-quantitative analysis of medium- and long-chain fatty acids using multiple reaction monitoring.
Wei J, Xiao X, Li K, Song Y, Huang SK, Cai Z, Liu Z. Wei J, et al. Talanta. 2021 Oct 1;233:122464. doi: 10.1016/j.talanta.2021.122464. Epub 2021 May 15. Talanta. 2021. PMID: 34215101
Medium- and long-chain fatty acids (MLFAs) are essential energy sources in cells and possess vital biological functions. ...Herein, a derivatization strategy was applied by labeling with d0-N, N-dimethyl-6,7-dihydro-5H-pyrrolo [3,4-d] pyr …
Medium- and long-chain fatty acids (MLFAs) are essential energy sources in cells and possess vital biological functions. ...Herein, a …
Derivatization strategy combined with parallel reaction monitoring for the characterization of short-chain fatty acids and their hydroxylated derivatives in mouse.
Wei J, Xiang L, Li X, Song Y, Yang C, Ji F, Chung ACK, Li K, Lin Z, Cai Z. Wei J, et al. Anal Chim Acta. 2020 Mar 1;1100:66-74. doi: 10.1016/j.aca.2019.11.009. Epub 2019 Nov 13. Anal Chim Acta. 2020. PMID: 31987154
Short-chain fatty acids (SCFAs) and hydroxylated short-chain fatty acids (OH-SCFAs) are crucial intermediates related to a variety of diseases, such as bowel disease, cardiovascular disease, renal disease and cancer. A global profiling method to screen SCFAs and OH- …
Short-chain fatty acids (SCFAs) and hydroxylated short-chain fatty acids (OH-SCFAs) are crucial intermediates related to a var …
Selectivity of BI 689648, a Novel, Highly Selective Aldosterone Synthase Inhibitor: Comparison with FAD286 and LCI699 in Nonhuman Primates.
Weldon SM, Cerny MA, Gueneva-Boucheva K, Cogan D, Guo X, Moss N, Parmentier JH, Richman JR, Reinhart GA, Brown NF. Weldon SM, et al. J Pharmacol Exp Ther. 2016 Oct;359(1):142-50. doi: 10.1124/jpet.116.236463. Epub 2016 Aug 1. J Pharmacol Exp Ther. 2016. PMID: 27481775
Using cynomolgus (cyno) monkey-based models, we identified BI 689648 [6-(5-methoxymethyl-pyridin-3-yl)-3,4-dihydro-2H-[1,8]naphthyridine-1-carboxylic acid amide], a novel, highly selective ASI that exhibits an in vitro IC50 of 2 nM against AS and 300 nm against CS (150-fol …
Using cynomolgus (cyno) monkey-based models, we identified BI 689648 [6-(5-methoxymethyl-pyridin-3-yl)-3,4-dihydro-2H-[1,8]naphthyridine-1-c …
Discovery of a novel potent GPR40 full agonist.
Meegalla SK, Huang H, Martin T, Xu J, Zhao S, Liu J, Hall M, Gunnet J, Wang Y, Rady B, Silva J, Otieno M, Arnoult E, Paul Lee S, Pocai A, Player MR. Meegalla SK, et al. Bioorg Med Chem Lett. 2018 Feb 15;28(4):720-726. doi: 10.1016/j.bmcl.2018.01.013. Epub 2018 Jan 12. Bioorg Med Chem Lett. 2018. PMID: 29366647
Pharmacology of the pyrroloimidazole, SK&F 105809--II. Antiinflammatory activity and inhibition of mediator production in vivo.
Griswold DE, Marshall PJ, Lee JC, Webb EF, Hillegass LM, Wartell J, Newton J Jr, Hanna N. Griswold DE, et al. Biochem Pharmacol. 1991 Jul 25;42(4):825-31. doi: 10.1016/0006-2952(91)90042-4. Biochem Pharmacol. 1991. PMID: 1907825
SK&F 105809 [2-(4-methylsulfinylphenyl)-3-(4-pyridyl)- 6,7-dihydro-[5H]-pyrrolo[1,2,a] imidazole] demonstrated unique antiinflammatory activities in murine models that are resistant to selective cyclooxygenase (CO) inhibitors. ...In spite of …
SK&F 105809 [2-(4-methylsulfinylphenyl)-3-(4-pyridyl)- 6,7-dihydro-[5H]-pyrrolo[1,2,a] imidazole] dem …
Retinoid-related orphan receptor gamma t (RORγt) inhibitors from Vitae Pharmaceuticals (WO2015116904) and structure proposal for their Phase I candidate VTP-43742.
Gege C. Gege C. Expert Opin Ther Pat. 2016 Jun;26(6):737-44. doi: 10.1517/13543776.2016.1153066. Epub 2016 Mar 4. Expert Opin Ther Pat. 2016. PMID: 26895086
Retinoic acid receptor-related orphan nuclear receptor gamma t (RORgammat or RORC2) is a key transcription factor for the differentiation of naive proinflammatory CD4(+) T cells and the production of T helper-17 (TH17) cells. ...The first relevant patent application (WO201 …
Retinoic acid receptor-related orphan nuclear receptor gamma t (RORgammat or RORC2) is a key transcription factor for the differentia …
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