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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1958 2
1959 1
1960 1
1963 1
1964 2
1965 1
1967 3
1969 3
1970 1
1971 1
1972 3
1973 1
1974 4
1975 7
1976 4
1977 5
1978 10
1979 8
1980 23
1981 21
1982 20
1983 28
1984 24
1985 32
1986 35
1987 30
1988 23
1989 28
1990 33
1991 26
1992 19
1993 25
1994 31
1995 21
1996 20
1997 28
1998 28
1999 35
2000 30
2001 23
2002 36
2003 35
2004 36
2005 24
2006 21
2007 19
2008 16
2009 17
2010 21
2011 16
2012 16
2013 31
2014 18
2015 16
2016 16
2017 15
2018 14
2019 16
2020 14
2021 12
2022 13
2023 10
2024 6

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1,034 results

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Page 1
Determination of 5-fluorocytosine, 5-fluorouracil, and 5-fluorouridine in hospital wastewater by liquid chromatography-mass spectrometry.
Škvára P, Santana-Viera S, Montesdeoca-Esponda S, Mordačíková E, Santana-Rodríguez JJ, Vojs Staňová A. Škvára P, et al. J Sep Sci. 2020 Aug;43(15):3074-3082. doi: 10.1002/jssc.202000144. Epub 2020 Jun 15. J Sep Sci. 2020. PMID: 32432394
In this paper, an analytical methodology was developed, validated, and applied to determine 5-fluorouracil, its precursor, 5-fluorocytosine, and its major active metabolite, 5-fluorouridine, in hospital wastewater samples. Due to the expected low concentrations afte …
In this paper, an analytical methodology was developed, validated, and applied to determine 5-fluorouracil, its precursor, 5-fluorocytosine, …
Population Pharmacokinetics of Intracellular 5-Fluorouridine 5'-Triphosphate and its Relationship with Hand-and-Foot Syndrome in Patients Treated with Capecitabine.
Janssen JM, Jacobs BAW, Roosendaal J, Derissen EJB, Marchetti S, Beijnen JH, Huitema ADR, Dorlo TPC. Janssen JM, et al. AAPS J. 2021 Jan 8;23(1):23. doi: 10.1208/s12248-020-00533-1. AAPS J. 2021. PMID: 33417061 Clinical Trial.
This might be a result of accumulation of intracellular metabolites. We characterised the pharmacokinetics (PK) of 5-fluorouridine 5'-triphosphate (FUTP) in peripheral blood mononuclear cells (PBMCs) and assessed the relationship between exposure to capecitabine or …
This might be a result of accumulation of intracellular metabolites. We characterised the pharmacokinetics (PK) of 5-fluorouridine …
Development of a UPLC-MS/MS Assay for the Quantitative Determination of Capecitabine, 5'-deoxy-5-fluorocytidine (5'-dFCR), 5'-deoxy-5-fluorouridine (5'-dFUR), 5'-fluorouracil (5-FU), and alpha-fluoro-beta-alanine (FBAL).
Knikman JE, de Vries N, Rosing H, Cats A, Guchelaar HJ, Beijnen JH. Knikman JE, et al. Pharmazie. 2023 Aug 1;78(8):107-112. doi: 10.1691/ph.2023.3001. Pharmazie. 2023. PMID: 37592424
In this study, an ultra-high performance liquid chromatography coupled to turbo ion spray tandem mass spectrometry (UPLC-MS/MS) method was developed and validated to quantify capecitabine and its metabolites including 5'-deoxy-5-fluorocytidine (5'-dFCR), 5'-deoxy-5-fluo …
In this study, an ultra-high performance liquid chromatography coupled to turbo ion spray tandem mass spectrometry (UPLC-MS/MS) method was d …
Synthesis and biological evaluation of 6-substituted-5-fluorouridine ProTides.
Slusarczyk M, Ferla S, Brancale A, McGuigan C. Slusarczyk M, et al. Bioorg Med Chem. 2018 Feb 1;26(3):551-565. doi: 10.1016/j.bmc.2017.11.037. Epub 2017 Dec 2. Bioorg Med Chem. 2018. PMID: 29277307 Free article.
A new family of thirteen phosphoramidate prodrugs (ProTides) of different 6-substituted-5-fluorouridine nucleoside analogues were synthesized and evaluated as potential anticancer agents. ...Our observations may support and explain to some extent the poor in vitro b …
A new family of thirteen phosphoramidate prodrugs (ProTides) of different 6-substituted-5-fluorouridine nucleoside analogues w …
Novel derivatives of 5-fluorouridine and 5-fluorouracil having potent antitumor and lower immunosuppressive activities.
Mori H, Sakamoto O, Kitaichi K, Koda A, Kita J. Mori H, et al. Jpn J Pharmacol. 1992 Mar;58(3):269-82. doi: 10.1254/jjp.58.269. Jpn J Pharmacol. 1992. PMID: 1513076 Free article.
We studied the biological activities of several 5-fluorouridine (5-FUR) and 5-fluorouracil (5-FU) derivatives to find novel antitumor drugs with lower immunosuppressive effects. ...Among the examined compounds, we found satisfactory activities in a derivative of 5-F …
We studied the biological activities of several 5-fluorouridine (5-FUR) and 5-fluorouracil (5-FU) derivatives to find novel an …
Translational readthrough of nonsense mutant TP53 by mRNA incorporation of 5-Fluorouridine.
Palomar-Siles M, Heldin A, Zhang M, Strandgren C, Yurevych V, van Dinter JT, Engels SAG, Hofman DA, Öhlin S, Meineke B, Bykov VJN, van Heesch S, Wiman KG. Palomar-Siles M, et al. Cell Death Dis. 2022 Nov 25;13(11):997. doi: 10.1038/s41419-022-05431-2. Cell Death Dis. 2022. PMID: 36433934 Free PMC article.
TP53 nonsense mutations in cancer produce truncated inactive p53 protein. We show that 5-FU metabolite 5-Fluorouridine (FUr) induces full-length p53 in human tumor cells carrying R213X nonsense mutant TP53. ...
TP53 nonsense mutations in cancer produce truncated inactive p53 protein. We show that 5-FU metabolite 5-Fluorouridine (FUr) i …
Optimal treatment regimens for 5'-deoxy-5-fluorouridine, with or without (E)-5-(2-bromovinyl)-2'-deoxyuridine, against various tumors in mice.
Iigo M, Miwa M, De Clercq E. Iigo M, et al. Jpn J Cancer Res. 1990 Apr;81(4):431-5. doi: 10.1111/j.1349-7006.1990.tb02586.x. Jpn J Cancer Res. 1990. PMID: 2142152 Free PMC article.
The antitumor activity of 5'-deoxy-5-fluorouridine (DFUR), a prodrug of 5-fluorouracil (5-FU), is markedly enhanced if DFUR treatment is combined with (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVDU). ...
The antitumor activity of 5'-deoxy-5-fluorouridine (DFUR), a prodrug of 5-fluorouracil (5-FU), is markedly enhanced if DFUR tr …
Chronic myeloid leukemia following chemotherapy with 5'-deoxy-5-fluorouridine for gastric cancer.
Tsuzuki M, Handa K, Yamamoto K, Hasegawa A, Yamamoto Y, Watanabe M, Mizuta S, Maruyama F, Okamoto M, Emi N, Ezaki K. Tsuzuki M, et al. Intern Med. 2008;47(19):1739-41. doi: 10.2169/internalmedicine.47.1072. Epub 2008 Oct 1. Intern Med. 2008. PMID: 18827427 Free article. Review.
We report here a very rare case of chronic myeloid leukemia (CML) following long-term chemotherapy with 5'-deoxy-5-fluorouridine (5'-DFUR) for gastric cancer. A 69-year-old man was diagnosed with the chronic phase of CML. ...
We report here a very rare case of chronic myeloid leukemia (CML) following long-term chemotherapy with 5'-deoxy-5-fluorouridine …
A comparison of 5-fluorouridine and 5-fluorouracil in an experimental model for the treatment of vitreoretinal scarring.
Ward T, Hartzer M, Blumenkranz M, Lin LR. Ward T, et al. Curr Eye Res. 1993 May;12(5):397-401. doi: 10.3109/02713689309024621. Curr Eye Res. 1993. PMID: 8344064
5-Fluorouridine (5-FUR), a ribonucleotide metabolite of 5-Fluorouracil (5-FU), is a more potent inhibitor of cellular proliferation and cell-mediated contraction in vitro than 5-FU. ...No 5-FUR treated eye developed extensive tractional or combined tractional and rh …
5-Fluorouridine (5-FUR), a ribonucleotide metabolite of 5-Fluorouracil (5-FU), is a more potent inhibitor of cellular prolifer …
Pharmacokinetic analysis of doxifluridine and its metabolites, 5-fluorouracil and 5-fluorouridine, after oral administration in beagle dogs.
Baek IH, Lee BY, Kim MS, Kwon KI. Baek IH, et al. Eur J Drug Metab Pharmacokinet. 2013 Dec;38(4):295-9. doi: 10.1007/s13318-013-0130-4. Epub 2013 Apr 7. Eur J Drug Metab Pharmacokinet. 2013. PMID: 23564503
Doxifluridine (5'-deoxy-5-fluorouridine, 5'-dFUR) is a fluoropyrimidine derivative that is activated preferentially in malignant cells by thymidine phosphorylase to form 5-fluorouracil (5-FU). The purpose of this study was to investigate the pharmacokinetic properti …
Doxifluridine (5'-deoxy-5-fluorouridine, 5'-dFUR) is a fluoropyrimidine derivative that is activated preferentially in maligna …
1,034 results