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Unknown field was ignored: [3,2-b]
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Involvement of DAAO Overexpression in Delayed Hippocampal Neuronal Death.
Cells. 2022 Nov 21;11(22):3689. doi: 10.3390/cells11223689.
Cells. 2022.
PMID: 36429117
Free PMC article.
BACKGROUND: D-amino acid oxidase (DAAO) is a flavoenzyme that specifically catalyzes the deamination of many neutral and basic D-amino acids. ...Thus, it is supposed that the activation of astrocytic DAAO in ischemic stroke might contribute to neuronal death. An int …
BACKGROUND: D-amino acid oxidase (DAAO) is a flavoenzyme that specifically catalyzes the deamination of many neutral and basic D-amin …
Effects of D-amino acid oxidase inhibition on memory performance and long-term potentiation in vivo.
Hopkins SC, Campbell UC, Heffernan ML, Spear KL, Jeggo RD, Spanswick DC, Varney MA, Large TH.
Hopkins SC, et al.
Pharmacol Res Perspect. 2013 Oct;1(1):e00007. doi: 10.1002/prp2.7. Epub 2013 Oct 1.
Pharmacol Res Perspect. 2013.
PMID: 25505561
Free PMC article.
N-methyl-d-aspartate receptor (NMDAR) activation can initiate changes in synaptic strength, evident as long-term potentiation (LTP), and is a key molecular correlate of memory formation. Inhibition of d-amino acid oxidase (DAAO) may increase NMDAR activity by regulating d- …
N-methyl-d-aspartate receptor (NMDAR) activation can initiate changes in synaptic strength, evident as long-term potentiation (LTP), and is …
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Continuous flow thermolysis of azidoacrylates for the synthesis of heterocycles and pharmaceutical intermediates.
O'Brien AG, Lévesque F, Seeberger PH.
O'Brien AG, et al.
Chem Commun (Camb). 2011 Mar 7;47(9):2688-90. doi: 10.1039/c0cc04481d. Epub 2010 Dec 20.
Chem Commun (Camb). 2011.
PMID: 21173952
The scalability of the process was demonstrated in the continuous flow synthesis of a precursor to the DAAO inhibitor 4H-furo[3,2-b]pyrrole-5-carboxylic acid....
The scalability of the process was demonstrated in the continuous flow synthesis of a precursor to the DAAO inhibitor 4H-furo[ …
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Pharmacodynamic effects of a D-amino acid oxidase inhibitor indicate a spinal site of action in rat models of neuropathic pain.
Hopkins SC, Zhao FY, Bowen CA, Fang X, Wei H, Heffernan ML, Spear KL, Spanswick DC, Varney MA, Large TH.
Hopkins SC, et al.
J Pharmacol Exp Ther. 2013 Jun;345(3):502-11. doi: 10.1124/jpet.113.204016. Epub 2013 Mar 21.
J Pharmacol Exp Ther. 2013.
PMID: 23520265
Free article.
Inhibition of d-amino acid oxidase (DAAO) activity is a potential target for the treatment of chronic pain. Here we characterized the effects of systemic administration of the DAAO inhibitor 4H-furo[3,2-b]pyrrole-5-carboxylic acid …
Inhibition of d-amino acid oxidase (DAAO) activity is a potential target for the treatment of chronic pain. Here we characterized the …
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