A retrospective study of 56 patients upon whom 76 interdigital neuromas were excised was carefully evaluated. There were 53 females and 3 males, with an average age of 55 years. The main preoperative symptom was pain in the plantar aspect of the foot which was increased by walking and relieved by rest. The main preoperative physical finding was that of tenderness in the involved interspace. There were an equal number of interdigital neuromas removed from the second and third interspace. Postoperatively 65% of patients still noted some local plantar tenderness, and 68% noted numbness in the interspace. Postoperatively 80% of the patients were subjectively improved.