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Effect of Chaihu Shugan Pills on the Pharmacokinetics of Duloxetine and its Metabolite 4-Hydroxyduloxetine in Beagle Dogs: A Herb-Drug Interaction Study.
Bi YT, Kang YR, Woshur G, Ding HZ, Wang SS, Qiu XJ. Bi YT, et al. Evid Based Complement Alternat Med. 2022 Aug 17;2022:2350560. doi: 10.1155/2022/2350560. eCollection 2022. Evid Based Complement Alternat Med. 2022. PMID: 36034951 Free PMC article.
The effect of Chaihu Shugan pills (CHSG) on the pharmacokinetics of duloxetine and its metabolite 4-hydroxyduloxetine in beagle dogs was investigated by establishing an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method to simultane …
The effect of Chaihu Shugan pills (CHSG) on the pharmacokinetics of duloxetine and its metabolite 4-hydroxyduloxetine in beagl …
Determination of duloxetine in human plasma with proven lack of influence of the major metabolite 4-hydroxyduloxetine.
Kaza M, Gilant E, Filist M, Szlaska I, Pawiński T, Rudzki PJ. Kaza M, et al. Clin Biochem. 2014 Sep;47(13-14):1313-5. doi: 10.1016/j.clinbiochem.2014.05.059. Epub 2014 Jun 2. Clin Biochem. 2014. PMID: 24886771
DESIGN AND METHODS: This paper describes a simple and rapid HPLC-UV method for the determination of duloxetine, a potent serotonin and norepinephrine reuptake inhibitor, in the presence of its major metabolite, i.e. 4-hydroxyduloxetine glucuronide. Analyte and fluox …
DESIGN AND METHODS: This paper describes a simple and rapid HPLC-UV method for the determination of duloxetine, a potent serotonin and norep …
Screening of 16 major drug glucuronides for time-dependent inhibition of nine drug-metabolizing CYP enzymes - detailed studies on CYP3A inhibitors.
Kahma H, Paludetto MN, Neuvonen M, Kurkela M, Filppula AM, Niemi M, Backman JT. Kahma H, et al. Eur J Pharm Sci. 2024 Feb 27:106735. doi: 10.1016/j.ejps.2024.106735. Online ahead of print. Eur J Pharm Sci. 2024. PMID: 38423227 Free article.
Seven glucuronides (carvedilol beta-D-glucuronide, diclofenac acyl-beta-D-glucuronide, 4-hydroxyduloxetine beta-D-glucuronide, ezetimibe phenoxy-beta-D-glucuronide, raloxifene 4'-glucuronide, repaglinide acyl-beta-D-glucuronide and valproic acid beta-D-glucuronide) …
Seven glucuronides (carvedilol beta-D-glucuronide, diclofenac acyl-beta-D-glucuronide, 4-hydroxyduloxetine beta-D-glucuronide, …