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The following terms were not found in PubMed: 2-amino-4-chloro-phenyl, -3-fluoro-benzonitrile
Page 1
2,4,6-Trimethyl-3,5-bis[(phenylcarbono-thioyl)sulfanylmethyl]benzyl benzenecarbodithioate.
Kannan M, Ramkumar V, Dhamodharan R. Kannan M, et al. Acta Crystallogr Sect E Struct Rep Online. 2010 May 19;66(Pt 6):o1382. doi: 10.1107/S1600536810016028. Acta Crystallogr Sect E Struct Rep Online. 2010. PMID: 21579463 Free PMC article.
The dihedral angles between the central benzene ring and the three pendant rings are 72.54 (4), 89.68 (4) and 86.74 (4). In the crystal structure, one of the benzene rings is disordered over two orientations in a 0.559 (13):0.441 (13) ratio....
The dihedral angles between the central benzene ring and the three pendant rings are 72.54 (4), 89.68 (4) and 86.74 (4) …
Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371.HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.
Chappell MD, Li R, Smith SC, Dressman BA, Tromiczak EG, Tripp AE, Blanco MJ, Vetman T, Quimby SJ, Matt J, Britton TC, Fivush AM, Schkeryantz JM, Mayhugh D, Erickson JA, Bures MG, Jaramillo C, Carpintero M, Diego JE, Barberis M, Garcia-Cerrada S, Soriano JF, Antonysamy S, Atwell S, MacEwan I, Condon B, Sougias C, Wang J, Zhang A, Conners K, Groshong C, Wasserman SR, Koss JW, Witkin JM, Li X, Overshiner C, Wafford KA, Seidel W, Wang XS, Heinz BA, Swanson S, Catlow JT, Bedwell DW, Monn JA, Mitch CH, Ornstein PL. Chappell MD, et al. J Med Chem. 2016 Dec 22;59(24):10974-10993. doi: 10.1021/acs.jmedchem.6b01119. Epub 2016 Dec 6. J Med Chem. 2016. PMID: 28002967
Exploration of this structure-activity relationship (SAR) led to the identification of (1S,2R,3S,4S,5R,6R)-2-amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid hydrochloride (LY3020371.HCl, 19f), a potent, select …
Exploration of this structure-activity relationship (SAR) led to the identification of (1S,2R,3S,4S,5R,6R)-2-amino-3-[(3,4-difluoroph …
cis-1,2-Bis{[4-(4-pyrid-yl)pyrimidin-2-yl]sulfanylmeth-yl}benzene.
Dong HZ, Zhu HB, Gou SH. Dong HZ, et al. Acta Crystallogr Sect E Struct Rep Online. 2009 Nov 4;65(Pt 12):o2977. doi: 10.1107/S1600536809045450. Acta Crystallogr Sect E Struct Rep Online. 2009. PMID: 21578717 Free PMC article.
Intra-molecular pi-pi inter-actions between the pyrimidine rings [centroid-centroid distance = 3.654 (2) A] and between the pyridine rings [centroid-centroid distance = 3.775 (2) A] help to set the mol-ecular conformation; the pyrimidine rings, as well as the pyridine rings, are …
Intra-molecular pi-pi inter-actions between the pyrimidine rings [centroid-centroid distance = 3.654 (2) A] and between the pyridine rings [ …
3-{[4-(4-Pyrid-yl)pyrimidin-2-yl]sulfanylmeth-yl}benzoic acid.
Zhu HB, Wang H, Ji JF. Zhu HB, et al. Acta Crystallogr Sect E Struct Rep Online. 2008 Nov 13;64(Pt 12):o2347. doi: 10.1107/S1600536808036799. Acta Crystallogr Sect E Struct Rep Online. 2008. PMID: 21581321 Free PMC article.
The title compound, C(17)H(13)N(3)O(2)S, was prepared by reaction of 4-(4-pyrid-yl)pyrimidine-2-thiol with 3-(bromo-meth-yl)benzoic acid under basic conditions. ...
The title compound, C(17)H(13)N(3)O(2)S, was prepared by reaction of 4-(4-pyrid-yl)pyrimidine-2-thiol with 3-(bromo-meth-yl)be …
Synthesis and anti-inflammatory activity of derivatives of 5-[(2-disubstitutedamino-6-methyl-pyrimidin-4-yl)-sulfanylmethyl]-3H-1,3,4-oxadiazole-2-thiones.
Burbuliene MM, Jakubkiene V, Mekuskiene G, Udrenaite E, Smicius R, Vainilavicius P. Burbuliene MM, et al. Farmaco. 2004 Oct;59(10):767-74. doi: 10.1016/j.farmac.2004.05.007. Farmaco. 2004. PMID: 15474053
Synthesis and results of anti-inflammatory activity in vivo of 5-[(2-disubstitutedamino-6-methyl-pyrimidin-4-yl)-sulfanylmethyl]-3H-1,3,4-oxadiazole-2-thiones and their S-alkyl-, N(3)-acyl- and N(3)-aminomethyl derivatives are described. All the tested compou …
Synthesis and results of anti-inflammatory activity in vivo of 5-[(2-disubstitutedamino-6-methyl-pyrimidin-4-yl)-sulfanylmethyl …
5-(2,6-Dimethoxy-phen-oxy)-2-methyl-sulfanylmethyl-2H-tetra-zole.
Noroozi Pesyan N, Omidkhah N, Maghsoodi M, Patrick BO. Noroozi Pesyan N, et al. Acta Crystallogr Sect E Struct Rep Online. 2009 Feb 28;65(Pt 3):o655. doi: 10.1107/S1600536809006138. Acta Crystallogr Sect E Struct Rep Online. 2009. PMID: 21582303 Free PMC article.
In the title mol-ecule, C(11)H(14)N(4)O(3)S, the tetra-zole and benzene rings are nearly perpendicular to each other, forming a dihedral angle of 104.93 (14). ...
In the title mol-ecule, C(11)H(14)N(4)O(3)S, the tetra-zole and benzene rings are nearly perpendicular to each other, forming a dihed …
The mixed diol-dithiol 2,2-bis(sulfanylmethyl)propane-1,3-diol: characterization of key intermediates on a new synthetic pathway.
Simmons TR, Pickett CJ, Wright JA. Simmons TR, et al. Acta Crystallogr C. 2011 Jan;67(Pt 1):o1-5. doi: 10.1107/S0108270110049371. Epub 2010 Dec 8. Acta Crystallogr C. 2011. PMID: 21206075
A new synthetic route to 2,2-bis(sulfanylmethyl)propane-1,3-diol, (II), is described starting from the commercially available 2,2-bis(hydroxymethyl)propane-1,3-diol. ...It forms a zigzag structure as a result of intermolecular hydrogen bonding. The structure of 9,9-dimethy …
A new synthetic route to 2,2-bis(sulfanylmethyl)propane-1,3-diol, (II), is described starting from the commercially available 2,2-bis …
Identification of a new member of Mortaparib class of inhibitors that target mortalin and PARP1.
Meidinna HN, Shefrin S, Sari AN, Zhang H, Dhanjal JK, Kaul SC, Sundar D, Wadhwa R. Meidinna HN, et al. Front Cell Dev Biol. 2022 Sep 12;10:918970. doi: 10.3389/fcell.2022.918970. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36172283 Free PMC article.
In this premise, we earlier screened a chemical library to identify potential disruptors of mortalin-p53 interaction, and reported two novel synthetic small molecules (5-[1-(4-methoxyphenyl) (1,2,3,4-tetraazol-5-yl)]-4-phenylpyrimidine-2-ylamine) and (4 …
In this premise, we earlier screened a chemical library to identify potential disruptors of mortalin-p53 interaction, and reported two novel …
Sulfanylmethyldimethylaminopyridine as a Useful Thiol Additive for Ligation Chemistry in Peptide/Protein Synthesis.
Ohkawachi K, Kobayashi D, Morimoto K, Shigenaga A, Denda M, Yamatsugu K, Kanai M, Otaka A. Ohkawachi K, et al. Org Lett. 2020 Jul 17;22(14):5289-5293. doi: 10.1021/acs.orglett.0c01383. Epub 2020 May 12. Org Lett. 2020. PMID: 32396369
Sulfanylmethyl-installed dimethylaminopyridine, 2-sulfanylmethyl-4-dimethylaminopyridine (2), has an acidic thiol group comparable to that in aryl thiols due to the formation of a zwitterion consisting of a thiolate anion and a pyridinium cation. ...
Sulfanylmethyl-installed dimethylaminopyridine, 2-sulfanylmethyl-4-dimethylaminopyridine (2), has an acidic thiol group …
33 results